Synonyms Activin receptor-like kinase 3, ACVRLK3, ALK-3 + [10] |
Introduction On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. |
Target |
Mechanism BMPR1A stimulants [+1] |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication- |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. KR |
First Approval Date25 Jun 2014 |
Target |
Mechanism BMPR1A stimulants |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. EU [+3] |
First Approval Date09 Sep 2002 |
Start Date01 Aug 2024 |
Sponsor / Collaborator |
Start Date01 Jul 2023 |
Sponsor / Collaborator |
Start Date06 Dec 2021 |
Sponsor / Collaborator |