Collagen I

BRANCHBURG, N.J., May 9, 2023 /PRNewswire/ -- A study recently published in the Journal of Food & Nutritional Sciences, found that Lycored's astaxanthin prevented against collagen damage from neutrophils, discovering its potential to protect collagen and enhance skin health. This study assessed the addition of astaxanthin to neutrophils, the key players in the skin's immune response and photoaging, and the combined effects on collagen presence. The two most prevalent types of collagen are I and III, which play major roles in skin elasticity. When skin is exposed to damaging elements it triggers an immune response in the skin that signals neutrophils, which try to eliminate the harmful effects, and in the process release free radicals that damage or break down collagen. In this study, researchers mimicked this process of triggering a neutrophil immune response using Tumor Necrosis Factor alpha (TNF-a). When astaxanthin levels (5-50uM) were added to TNF-a primed neutrophils, a dose-dependent restraint was found in free radical activity released by neutrophils, and subsequent collagen I and III damage. The addition of 50 uM of astaxanthin prevented collagen I loss by 28.1±8%, and collagen III loss by 49.4±5.9%. It also did not impact cell numbers, or affect the expression of collagen I and III, which shows astaxanthin's effect is specific to the inhibition of free radical activity released by neutrophils, which damage cells during a response to environmental triggers (e.g., exposure to sunlight). Not only does this indicate astaxanthin's potential for enhanced skin benefits, but since collagen makes up the majority of cartilage in knees and joints, it also indicates potential support for those with an active lifestyle. Lycored's astaxanthin uses algae-derived (Haematococcus pluvialis) astaxanthin carotenoid with anti-oxidative and anti-inflammatory properties that provides a multitude of science-backed benefits. Previous studies have also linked astaxanthin to positive sports recovery results, cellular health, heart health, joint health, immune systems support and mitigation of oxidative damage and inflammation. Astaxanthin cannot be synthesized by humans and, therefore, must be consumed in the diet via food or supplements. Elizabeth Tarshish, PhD, Head of Claims and Clinical Affairs at Lycored states, "This study not only showcases astaxanthin's capabilities for skin health, but also underscores how beneficial astaxanthin can be for joint health and recovery for active individuals. At Lycored, we strive to help people discover beauty from within, so we're excited about what these results mean for the preventive health benefits of astaxanthin throughout the body." View the full study at: Astaxanthin Supports Normal Human Dermal Fibroblasts from Neutrophil-Induced Collagen Damage in Co-Culture (starlingscience.com) About Lycored Lycored is an international company at the forefront of discovering beauty from within by combining nature's goodness with cutting edge science to deliver a sensory journey that impacts wellbeing. Established in 1995 in Israel, Lycored is the global leader in natural carotenoids for food, beverage and dietary supplement products. For more information visit . Contact Katie Hill Padilla +1 480 285 8148 [email protected] Logo - SOURCE Lycored

The biotechnology company will debut its first product at the in-cosmetics Global trade show from March 28-30, in Barcelona NovaColl product image. (Credit: GlobeNewswire, Inc./ Cambrium) Biotechnology company Cambrium has launched its first product: NovaColl. It is the first micro-molecular & 100% skin-identical collagen specifically designed for premium personal care formulations. Owing to its structure and small molecular size, NovaColl is able to create powerful collagen benefits across skin layers. This new class of collagen active is vegan certified and produced through Cambrium’s precision fermentation process, offering formulators a unique combination of efficacy, skin-compatibility and sustainability. NovaColl’s claims have been scientifically validated in third party in vitro studies, which demonstrated a broad range of activities working to holistically protect, maintain and enhance native collagen. Beyond bio-similarity, NovaColl is 100% skin-identical, offering previously inaccessible levels of biocompatibility for personal care applications. To achieve this, Cambrium’s multi-disciplinary team of scientists and engineers searched through billions of protein sequences for skin-active features and indicators of efficacy. They identified NovaColl, a highly bioactive region of collagen I, the most prevalent collagen type in our human skin. Rather than extracting collagen from animals, Cambrium uses yeast cells to grow their micro-molecular collagen in a cruelty-free and sustainable fermentation process, minimizing energy, land, and water use. Source: Company Press Release

BERLIN, March 23, 2023 (GLOBE NEWSWIRE) -- Biotechnology company Cambrium has launched its first product: NovaColl™. It is the first micro-molecular & 100% skin-identical collagen specifically designed for premium personal care formulations. Owing to its structure and small molecular size, NovaColl™ is able to create powerful collagen benefits across skin layers. This new class of collagen active is vegan certified and produced through Cambrium’s precision fermentation process, offering formulators a unique combination of efficacy, skin-compatibility and sustainability. NovaColl™’s claims have been scientifically validated in third party in vitro studies, which demonstrated a broad range of activities working to holistically protect, maintain and enhance native collagen. Beyond bio-similarity, NovaColl™ is 100% skin-identical, offering previously inaccessible levels of biocompatibility for personal care applications. To achieve this, Cambrium’s multi-disciplinary team of scientists and engineers searched through billions of protein sequences for skin-active features and indicators of efficacy. They identified NovaColl™, a highly bioactive region of collagen I, the most prevalent collagen type in our human skin. Rather than extracting collagen from animals, Cambrium uses yeast cells to grow their micro-molecular collagen in a cruelty-free and sustainable fermentation process, minimizing energy, land, and water use. Cambrium will exhibit at booth AK84 at the in-cosmetics Global trade show from March 28-30 in Barcelona, Spain. For more information about NovaColl™ and to request a meeting, please write to novacoll@cambrium.bio. About Cambrium Cambrium’s mission is to trigger the next wave of sustainable product innovation through the creation of new, high performance molecules. Using their technology-enabled molecular design platform, they discover, develop and manufacture proteins that unlock previously inaccessible functionalities. For more information, visit . A photo accompanying this announcement is available at NovaColl™ image NovaColl™ product image