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Last update 08 May 2025

GPR180

Last update 08 May 2025

Basic Info

Synonyms

G protein-coupled receptor 180, GPR180, Integral membrane protein GPR180

+ [2]

Introduction-

Drugs associated with GPR180

CN115997006

Patent Mining

Target

GPR180

Mechanism-

Active Org.

uniQure biopharma BV

Originator Org.

uniQure biopharma BV

Active Indication

Infectious Diseases

Inactive Indication-

Drug Highest PhaseDiscovery

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with GPR180

100 Translational Medicine associated with GPR180

0 Patents (Medical) associated with GPR180

Literatures (Medical) associated with GPR180

01 Mar 2025·American Journal of Physiology-Endocrinology and Metabolism

GPR180 reduces adiposity by inhibiting lipogenesis and fatty acid uptake in adipocytes

Article

Author: Sun, Lijun ; Han, Xue ; Zhang, Weizhen ; Yang, Yaxu ; Luo, Chao ; Yin, Yue ; Zhang, Yunhua ; Zhu, Ziming

This study identifies GPR180 as a novel regulator of lipid metabolism and energy homeostasis. It demonstrates that GPR180 influences adipose tissue function, mitigates high-fat diet-induced obesity, and inhibits lipogenesis. Unique expression patterns and GWAS data linking GPR180 to lipid regulation highlight its systemic role. These findings establish GPR180 as a promising therapeutic target for metabolic disorders, warranting further research to uncover its molecular mechanisms and clinical applications.

24 Jan 2025·Nucleic Acids Research

AAV vector transduction restriction and attenuated toxicity in hESCs via a rationally designed inverted terminal repeat

Article

Author: Song, Liujiang ; Hirsch, Matthew L ; Bower, Jacquelyn J ; Samulski, Richard J ; Hasegawa, Tomoko ; Brown, Nolan J

AbstractAdeno-associated virus (AAV) inverted terminal repeats (ITRs) induce p53-dependent apoptosis in human embryonic stem cells (hESCs). To interrogate this phenomenon, a synthetic ITR (SynITR), harboring substitutions in putative p53 binding sites was generated and evaluated for vector production and gene delivery. Replication of SynITR flanked transgenic genome was similar compared to wild type (wt) ITR, with a modest increase in vector titers. Packaged in the AAV2 capsid, wtITR and SynITR vectors demonstrated similar transduction efficiencies of human cells without toxicity. Following AAV2-wtITR vector infection of hESCs, rapid apoptosis was observed as reported. In contrast, infection by AAV2 vectors packaged with SynITRs attenuated the wtITR-induced hESC toxicity. While hESC particle entry and the abundance of double stranded circular episomes was similar for the ITR contexts, reporter expression was inhibited from transduced SynITR genomes. Mechanistically, infection of hESCs induced γH2AX in an ITR-independent manner, however, canonical activation of p53α was uncoupled using AAV-SynITR. Further investigations in hESCs revealed additional novel findings: (i) p53β is uniquely and constitutively active and (ii) AAV vector infection, independent of the ITR sequence, induces activation of p53ψ. The data herein reveal an ITR-dependent AAV vector transduction restriction specific to hESCs and manipulation of the DNA damage response via ITR engineering.

01 Jan 2025·Early Human Development

Is neutrophil to lymphocyte ratio an accurate predictor of neonatal sepsis in premature infants?

Article

Author: Kotsanas, Despina ; Tan, Kenneth ; Buttery, Jim ; Binny, Rachel ; Korman, Tony

BACKGROUNDSepsis is a significant cause of neonatal mortality. Both clinical and laboratory markers are often non- specific, and a blood culture contaminant may confuse management of the infant. This study aims to use an existing, inexpensive test, the neutrophil-to-lymphocyte ratio (NLR), to predict culture positivity and thus optimise antibiotic management.METHODSData on infants born ≤32 weeks gestation from 2015 to 2020 who were treated for sepsis were analyzed. Episodes were categorised based on culture positivity: i) positive with known pathogens, ii) true positive with coagulase-negative staphylococci (CoNS), iii) false positive with CoNS contaminants, iv) positive with other contaminants, and v) negative culture. NLR was compared with late C-reactive protein (CRP) and immature-to-total neutrophil ratio (ITR). Receiver operating curve (ROC) analysis was performed in this study. A cut- off value of 1.2 was chosen for NLR to detect culture.RESULTSA total of 2024 infants were included in the study, with no significant differences in demographics between groups. Infants with positive blood cultures of known pathogens had higher median NLR of 1.44 compared with those with contaminants (0.75) or negative cultures (0.84). A NLR cut-off value of 1.2 gave a sensitivity of 65.7 % and specificity of 63.7 %.The area under the curve (AUC) for NLR, late CRP and ITR were 0.71, 0.64 and 0.57 respectively. Combining NLR with late CRP would increase the AUC to 0.78 (95 % C·I 0.75-0.82, p < 0.01), whereas the addition of ITR to NLR and late CRP would not improve this. In a secondary analysis, between true and contaminant CoNS positivity, NLR and ITR could not be used to differentiate between these groups (p < 0.05 and 0.33), but late CRP could (p < 0.01).CONCLUSIONSClinicians should consider the use of NLR as an adjunct biomarker to late CRP in detecting culture positive sepsis in premature neonates. The use of ITR does not improve diagnostic accuracy for sepsis.

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GPR180

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