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Fundraising Includes Strategic Investment by Bristol Myers Squibb Coupled with Support from Existing Investors EvolveImmune Initiates Chemistry, Manufacturing, and Control (CMC) Activities for Lead Multi-Functional T-cell Engager Program, EV-104, Following Presentation of Latest Preclinical Data at SITC 2023 BRANFORD, CT, USA I December 13, 2023 I EvolveImmune Therapeutics, an immuno-oncology company developing first-in-category, multifunctional biotherapeutics to overcome the therapeutic challenges of cancer cell resistance to current immune therapy agents, today provided a corporate and program update related to the advancement of its pipeline of first-in-category precision immuno-oncology agents. The company announced the closing of a $37 million financing round, which was supported by existing investors including Pfizer Ventures, Solasta Ventures, and Takeda Ventures, Inc., along with new strategic investor Bristol Myers Squibb. EvolveImmune intends to use the proceeds from this fundraising to support continued platform and pipeline development including the advancement of its lead multi-functional T-cell engager program, EV-104. To this end, the company also announced the initiation of chemistry, manufacturing, and control (CMC) activities for EV-104 following its recent presentation of preclinical data demonstrating robust anti-tumor efficacy for the program in patient-derived solid tumor models at the 38 th Annual Meeting of the Society for Immunotherapy of Cancer (SITC). “This new capital raise comes at an exciting time for EvolveImmune,” said Stephen Bloch, M.D., chief executive officer of EvolveImmune. “With our EVOLVE platform, we believe we are at the forefront of unlocking the true potential of immunotherapy for the treatment of solid tumors. Our differentiated CD2 costimulation strategy for T cell engagers together with our recently unveiled pioneering insights on tumor features, which regulate tumor antigen expression and immune infiltration in the tumor microenvironment, are laying the groundwork for a new generation of immuno-oncology therapies for solid tumors driven by EVOLVE. This financing, including the investment from Bristol Myers Squibb, offers validation for our work to date on the EVOLVE platform and will enable us to continue to aggressively move our lead programs, including EV-104, through preclinical development and toward first-in-human studies.” The EVOLVE platform uniquely unleashes potent, selective and integrated T cell costimulation, which amplifies and sustains the tumor killing capacity of these T cells. This approach bypasses low tumor immunogenicity, conditionally activates adaptive immunity and reduces T cell dysfunction to address unmet needs for the treatment of solid and hematologic tumors. The platform also takes advantage the company’s understanding of specific tumor cell characteristics to guide tumor antigen prioritization and program differentiation. By pairing its distinctive costimulation strategy with these critical tumor-intrinsic attributes, EvolveImmune is developing an innovative pipeline of first-in-category precision immuno-oncology agents with an enhanced likelihood of clinical success. At the recent SITC 2023 conference, EvolveImmune spotlighted advances to the company’s first-in-class EV-104 program, a novel multi-functional T cell engager with integrated CD2 costimulation which conditionally targets ULBP2. Presented data demonstrated robust single-agent anti-tumor activity for EV-104 in patient-derived tumor models of bladder and lung cancer. Additionally, study results showed promising activity for EV-104 in combination with anti-PD1 therapy in pre-clinical models with patient-derived tumors, providing rationale for combination treatment approaches with checkpoint inhibitors. Importantly, the expression pattern for ULBP2, the target antigen for EV-104, is distinct from that of the solid tumor targets for a number of approved or investigational immunotherapies, suggesting opportunities for meaningful clinical differentiation. About EvolveImmune Therapeutics EvolveImmune Therapeutics, Inc. is an immunotherapy platform company developing first-in-category, multifunctional biotherapeutics designed to overcome cancer-driven immunodeficiency in a range of solid tumors and hematological cancers. First-in-human clinical trials are anticipated in 2024. The company is supported by a syndicate of top-tier life science industry investors including Pfizer Ventures, Solasta Ventures, Takeda Ventures, Inc., Yonjin Ventures and Elm Street Ventures. For more information, please visit: www.evolveimmune.com SOURCE: EvolveImmune Therapeutics

SAN MATEO, Calif., Dec. 06, 2023 (GLOBE NEWSWIRE) -- CARGO Therapeutics, Inc. (CRGX), a clinical-stage biotechnology company uniquely positioned to advance next generation, potentially curative cell therapies for cancer patients, today announced the formation of a Scientific Advisory Board (SAB) comprised of distinguished experts in cancer research, immunology, and CAR T-cell therapy. The SAB will be chaired by Robbie Majzner, MD, co-founder of CARGO and Director of the Pediatric and Young Adult Cancer Cell Therapy Program within the Departments of Pediatric Oncology and Medical Oncology at Dana Farber Cancer Institute and the Division of Hematology/Oncology at Boston Children’s Hospital. The SAB will provide strategic counsel and critical expertise as CARGO advances its mission to develop the next generation of transformational CAR T-cell therapies. “The formation of our distinguished SAB reaffirms our commitment to advance innovative cell therapies designed to address resistance mechanisms and increase the length of time that patients remain in remission,“ said Michael Ports, PhD, CARGO’s Chief Scientific Officer. “We look forward to leveraging the collective expertise of our SAB as we advance our platform technologies and our pipeline of next-generation, potentially transformative CAR T-cell therapies to make a meaningful impact on the lives of those affected by cancer." CARGO’s programs, platform technologies, and manufacturing strategy are designed to directly address the limitations of approved autologous CAR T-cell therapies, including limited durability, safety concerns and manufacturing supply constraints. The SAB will play a critical role in supporting CARGO’s research and development priorities as the company builds upon the development of its lead program CRG-022, an autologous CD22 directed CAR T-cell product, by leveraging their proprietary platform technologies, including engineered CD2 co-stimulation technology, to enable the development of multi-specific and multi-functional cellular therapy candidates that are engineered to address mechanisms that strongly associate with poor response and disease progression. “The SAB stands out by bringing together several highly accomplished translational investigators each with CAR T-cell experience that bridges both the laboratory and the clinic,” said Robbie Majzner, MD, co-founder of CARGO and Scientific Advisory Board Chair. “They are uniquely suited to advise CARGO on their scientific goals and directions that will lead to better outcomes for patients.” Members of the CARGO Scientific Advisory Board are listed below; full bios are available on the CARGO website. Robbie Majzner, MD, co-founder of CARGO and Scientific Advisory Board Chair, and Director of the Pediatric and Young Adult Cancer Cell Therapy Program within the Departments of Pediatric Oncology and Medical Oncology at Dana Farber Cancer Institute and the Division of Hematology/Oncology at Boston Children’s Hospital Stephen Gottschalk, MD, Chair of the Department of Bone Marrow Transplantation and Cellular Therapy at St Jude Children’s Research Hospital Andras Attila Heczey, MD, Professor, Department of Pediatrics of Baylor College of Medicine, Section of Pediatric Hematology and Oncology Marcela Maus, MD, PhD, Associate Professor at Harvard Medical School, the Paula O’Keefe Chair in Oncology, Director of Cellular Immunotherapy at Massachusetts General Hospital (MGH) Cancer Center, Attending Physician in the Hematopoietic Cell Transplant and Cell Therapy Division of Oncology at MGH Cameron Turtle, MBBS, PhD, Professor and CLEARbridge Chair in Cancer Immunotherapy in the Faculty of Medicine and Health at the University of Sydney; Clinical academic physician at Royal North Shore Hospital, Sydney, Australia About CARGO Therapeutics CARGO Therapeutics is a clinical-stage biotechnology company uniquely positioned to advance next generation, potentially curative cell therapies for cancer patients. CARGO’s programs, platform technologies, and manufacturing strategy are designed to directly address the limitations of approved cell therapies, including limited durability of effect, safety concerns and unreliable supply. CARGO is currently evaluating its lead program, CRG-022, an autologous CD22 chimeric antigen receptor (CAR) T-cell therapy candidate, in a potentially pivotal Phase 2 clinical trial in patients with large B-cell lymphoma (LBCL) whose disease relapsed or was refractory (R/R) to CD19 CAR T-cell therapy. CARGO also plans to evaluate CRG-022 in patients at earlier stages of disease, including LBCL and other hematologic malignancies. Beyond its lead program, CARGO is leveraging its proprietary cell engineering platform technologies to develop a pipeline of programs that incorporate multiple transgene therapeutic “cargo” designed to enhance CAR T-cell persistence and trafficking to tumor lesions, as well as to help safeguard against tumor resistance and T-cell exhaustion. CARGO’s founders are pioneers and world-class experts in CAR T-cell therapy, and its team has significant experience and success developing, manufacturing, launching and commercializing oncology and cell therapy products. For more information, please visit the CARGO Therapeutics website at . Find more information at cargo-tx.com Follow us on LinkedIn: CARGO Therapeutics Follow us on Twitter: @CARGOTx Media Contact: Maura Gavaghan maura@redhousecomms.com Investor Contact: Laurence Watts laurence@gilmartinir.com

PHILADELPHIA, Nov. 29, 2023 (GLOBE NEWSWIRE) -- Vittoria Biotherapeutics announced the presentations of abstracts authored by researchers at the University of Pennsylvania and a poster authored by the Company, at the upcoming 65th American Society of Hematology (ASH) Annual Meeting, taking place from December 9-12th, 2023, in San Diego, California. The presentations will showcase data from the laboratory of Marco Ruella, M.D., Vittoria’s Scientific Founder and Chair of the Scientific Advisory Board, who is an assistant professor of Medicine in the Perelman School of Medicine at the University of Pennsylvania (Penn) and Scientific Director of the Lymphoma Program at Penn Medicine’s Abramson Cancer Center. The oral presentations will include recent data generated at Penn with the Company’s Senza5™ platform, a technology exclusively licensed from Penn to Vittoria, along with additional pipeline technologies. By harnessing the fundamental biology of T cells, Senza5 is designed to engineer cell therapies with improved anti-tumor efficacy, stemness, potency, and durability through gene-edited CD5 knockout and a proprietary five-day manufacturing process. Oral and poster presentation abstracts to be presented at the meeting can be found below: Oral Presentations: Title: Disinhibition of T Cell Activation Via CD5 Knockout Is a Universal Strategy to Enhance Adoptive T Cell ImmunotherapiesSession: 703. Cellular Immunotherapies: Basic and Translational: Overcoming Challenges in CAR-T Therapies Through Biological InsightsPresenter: Ruchi P. Patel, M.S.Presentation Date and Time: Saturday, December 9th at 10:45 am PSTLocation: Room 6DE Title: Fratricide-Resistant Anti-CD2 Chimeric Antigen Receptor T-Cells with Endogenous CD2 Knockout Are Highly Effective Against T-Cell NeoplasmsSession: 703. Cellular Immunotherapies: Basic and Translational: Innovative T Cell Therapies for Unexplored Frontiers Presenter: Mathew G. Angelos, M.D., Ph.D.Presentation Date and Time: Monday, December 11th at 3:15 pm PSTLocation: Room 6DE Poster Presentation: Title: Senza5TM CART5: An Autologous CD5-Deleted Anti-CD5 CART Product with Enhanced Anti-T-Cell Lymphoma Activity Session: 703. Cellular Immunotherapies: Basic and Translational: Poster IIPresentation Date and Time: Sunday, December 10, 2023 at 6 pm PSTLocation: Halls G - H About Vittoria Biotherapeutics Vittoria Biotherapeutics, Inc., is developing novel CAR-T cell therapies that transcend the limitations of current cell therapies. Based on technology exclusively licensed from the University of Pennsylvania, the Company’s proprietary Senza5 platform unlocks the antitumor potential of engineered T cells and utilizes a five-day manufacturing process to maximize stemness, durability, and target cell cytotoxicity. By acting on the fundamental biology of T cells, Senza5 can be used to improve the efficacy of engineered T cell therapies with pipeline applications in oncology and autoimmune diseases. To learn more, visit vittoriabio.com and follow us on LinkedIn. Affiliations with the University of Pennsylvania Dr. Ruella is the scientific founder of, and an equity holder in, Vittoria Biotherapeutics. The University of Pennsylvania holds equity in Vittoria Biotherapeutics, has received sponsored research funding from Vittoria, has licensed certain intellectual property to Vittoria and may receive future funding and financial consideration based on development and commercialization of certain products by Vittoria. Dr. Ruella and Ruchi Patel are also paid consultants for Vittoria Biotherapeutics. Investor Contact Vittoria BiotherapeuticsNicholas A. Siciliano, Ph.D.Chief Executive Officer+1 215-600-1380 Media Contact LifeSci CommunicationsJason Braco, Ph.D.jbraco@lifescicomms.com+1 646-876-4932