A Phase 1/2 Study of the Safety and Preliminary Efficacy of Meldonium in Patients with Metastatic Renal Cell Carcinoma and Treatment-associated Fatigue.

Fatigue is a prevalent adverse event associated with systemic therapy using tyrosine kinase inhibitors (TKIs). Meldonium, a fatty acid oxidation inhibitor, modifies the carnitine pathway, a nutrient critical for fat metabolism. The World Anti-Doping Agency (WADA) classified meldonium as a banned substance due to its documented use by athletes aiming to enhance physical performance. In this study, the safety and preliminary efficacy of meldonium in treatment-related fatigue will be assessed.

Start Date01 Feb 2022

Sponsor / Collaborator-

CTR20140220

/ SuspendedPhase 3

评估标准加米屈肼治疗慢性缺血性心力衰竭患者有效性和安全性的双盲、随机、安慰剂平行对照、多中心临床研究

[Translation] A double-blind, randomized, placebo-controlled, multicenter clinical study to evaluate the efficacy and safety of standard plus meldonium in the treatment of patients with chronic ischemic heart failure

主要目标：评估标准治疗加米屈肼相比较于标准治疗加安慰剂治疗慢性缺血性心衰病人 (NYHA II- III 级）的疗效次要目标：评估米屈肼治疗慢性缺血性心衰病人的安全性

[Translation]

Primary objective: To evaluate the efficacy of meldonium plus standard therapy compared with standard therapy plus placebo in patients with chronic ischemic heart failure (NYHA class II-III) Secondary objective: To evaluate the safety of meldonium in patients with chronic ischemic heart failure

Start Date14 Jul 2014

Sponsor / Collaborator

Jsc Grindeks

[+1]

100 Clinical Results associated with BBOX

100 Translational Medicine associated with BBOX

0 Patents (Medical) associated with BBOX

184

Literatures (Medical) associated with BBOX

01 Jun 2025·Food Chemistry

Multi-omics analysis revealed the effects of different astaxanthin sources on the antioxidant properties of Scylla paramamosain

Article

Author: Zhou, Qicun ; Zhan, Wenhao ; Peng, Hongyu ; Xie, Shichao ; Jin, Min ; Tian, Yinqiu ; Deng, Yao ; Cao, Haiqing ; Zhu, Tingting ; Tang, Zheng ; Sun, Peng

Astaxanthin, a carotenoid present in many organisms, has antioxidant, coloration, and anti-inflammatory benefits, making it a safe and effective feed additive. In this study, Scylla paramamosain fed diets with 100 mg/kg synthetic astaxanthin and 25 mg/kg Haematococcus pluvialis exhibited the best growth performance. Increased astaxanthin levels in the feed also resulted in red coloration of the carapace. Transcriptomic and metabolomic analysis showed that synthetic astaxanthin promoted the metabolism of arachidonic acid (phosphatidycholine (PC, 35:3) and 20-hydroxyarachidonic acid through negative feedback regulation of carotenoids such as adh (alcohol dehydrogenase) and cyp2c (cytochrome p450 2c), thereby improving the antioxidant capacity such as sod1 (Cu/Zn superoxide dismutase), gsh-px (glutathione peroxidase), and bbox1 (gamma-butyrobetaine hydroxylase 1). Nature astaxanthin (Haematococcus Pluvialis) activates mitochondrial energy metabolism (ND2, ND4 and COX1, COX2, COX3) through negative feedback regulation of carotenoids (bcmo1, β-carotene-15,15'-monooxygenase 1), thereby improving the antioxidant capacity of crabs (sod1, fth1 (ferritin heavy chain) and bbox1).

13 Mar 2025·Journal of Medicinal Chemistry

In Situ NADH-Activated BODIPY-Based Macrocyclic Supramolecular Photosensitizer for Chemo-Photodynamic Synergistic Tumor Therapy

Article

Author: Liu, Yu ; Lei, Zhuo ; Song, Ya-Hui ; Leng, Yuan-Li ; Yu, Miao ; Yu, Qilin ; Gu, Yi-Jun ; Chen, Yong

Photodynamic therapy (PDT) based on supramolecular assembly has been receiving wide attention due to its great potential application in clinical treatment. Herein, we report a supramolecular photoelectron "reservoir" (SPR) constructed by tetracationic boron dipyrromethene (BODIPY)-based macrocycle (BBox·4Cl), doxorubicin (Dox), and tumor-targeted β-cyclodextrin-grafted hyaluronic acid (HACD). Upon irradiation, BBox·4Cl can in situ catalyze nicotinamide adenine dinucleotide (NADH) to continuously generate electrons to inject into SPR, which further transfers electrons to oxygen, inducing highly efficient hydroxyl radical generation even under hypoxia. Synergistically, Dox in SPR as "pump" can be encapsulated by BBox·4Cl and transport photoelectrons between two BODIPY units, while HACD as "sponge" can enrich BBox·4Cl by the electrostatic interaction to concentrate them closer in space, which facilitates intramolecular and intermolecular photoelectron transfer, respectively, and significantly enhances the generation of hydroxyl radicals. Meanwhile, electron replenishment in SPR causes NADH depletion and redox dysfunction, thereby accelerating the apoptosis and achieving highly effective synergistic tumor therapy.

01 Mar 2025·Advanced Healthcare Materials

NIR‐Actuated Botanicals/Nanozymes Nanofibrous Membranes for Antibiotic‐Free Triple‐Synergistic Therapy Against Polymicrobial Wound Infections

Article

Author: Dong, Kai ; Sun, Shuwen ; Lin, Wenbo ; Zhu, Tianyu ; Chen, Xiaoyuan ; Xu, Chen ; Zhang, Chenhao ; Cao, Fangfang

AbstractPolymicrobial wound infection represents a significant contributor to infectious disease‐related morbidity and mortality globally. Traditionally, the management of such infection relies heavily on high doses of antibiotics, often resulting in systemic side effects and exacerbating antibiotic resistance. Consequently, there is an urgent need to develop a safe and effective platform for antibiotic‐free treatment of polymicrobial wound infections. In this study, a near‐infrared (NIR) light‐actuated nanofibrous membrane incorporating botanicals and nanozymes is presented for antibiotic‐free triple‐synergistic therapy against polymicrobial wound infections. The membrane integrates berberine hydrochloride (BBH)‐loaded hollow zinc‐doped carbon nanocubes into polyvinyl alcohol (PVA) nanofibrous membranes. Upon low‐intensity 808 nm NIR laser irradiation (0.3 W cm−2), the membrane achieved a controlled release of BBH and enhanced peroxidase‐like (POD‐like) enzyme activity. This NIR light‐actuated botanical/photothermal therapy (PTT)/chemodynamic therapy (CDT) system demonstrated high efficacy in eradicating methicillin‐resistant Staphylococcus aureus and Pseudomonas aeruginosa both in vitro and in vivo. Furthermore, it mitigated inflammation and promoted wound healing in polymicrobial infection wounds, highlighting its potential as a promising alternative to antibiotic‐based therapies.

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