Request Demo

Last update 08 May 2025

CNDP1

Last update 08 May 2025

Basic Info

Synonyms

Beta-Ala-His dipeptidase, carnosinase 1, Carnosine dipeptidase 1

+ [9]

Introduction

Catalyzes the peptide bond hydrolysis in Xaa-His dipeptides, displaying the highest activity toward carnosine (beta-alanyl-L-histidine) and anserine (beta-alanyl-3-methyl-histidine).

Drugs associated with CNDP1

Astragalus propinquus extract

Target

CNDP1

Mechanism

CNDP1 inhibitors

Active Org.

Fujian Medical University Union Hospital [+1]

Originator Org.-

Active Indication

Alzheimer Disease [+1]

Inactive Indication

Aneurysm, Intracranial Berry, 1 [+2]

Drug Highest PhasePhase 2

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

HG-1426

Target

CNDP1

Mechanism

CNDP1 modulators

Active Org.-

Originator Org.

Human Genome Sciences, Inc.

Active Indication-

Inactive Indication

Cardiovascular Diseases [+2]

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with CNDP1

ITMCTR2024000812

/ SuspendedNot ApplicableIIT

Study on the role and mechanism of ginseng and astragalus therapeutic paste in intervening diabetes mellitus-related sarcopenia in elderly people

Start Date04 Jan 2025

Sponsor / Collaborator

Zhejiang Chinese Medical University

ITMCTR2024000722

/ SuspendedNot ApplicableIIT

Professor Deng Tietao a master of traditional Chinese medicine conducted a clinical efficacy and mechanism study on the Astragalus and Ephedra Formula in different dosage forms for the stable period of threshold in patients with bradyarrhythmia after pacemaker implantation.

Start Date01 Dec 2024

Sponsor / Collaborator-

ITMCTR2024000687

/ SuspendedPhase 4IIT

A Prospective Cohort Study on the Promotion of Postoperative Recovery after Uterine Operation with Astragalus and Gelatin Granules

Start Date20 Nov 2024

Sponsor / Collaborator

Peking University Third Hospital

100 Clinical Results associated with CNDP1

100 Translational Medicine associated with CNDP1

0 Patents (Medical) associated with CNDP1

132

Literatures (Medical) associated with CNDP1

01 Jul 2025·Poultry Science

Integrated transcriptomic and metabolomic analysis of goose epididymis reveals molecular markers associated with sperm mobility

Article

Author: Chen, Zhifeng ; Yang, Kun ; Ren, Xiaofang ; Jiang, Ke ; Yin, Jiaxin ; Ma, Zhigang ; Liu, Shengjun

The low fertility of geese has long constrained the development of the geese industry. Sperm quality plays a critical role in fertility, and sperm mobility (SM) serves as a key indicator of sperm quality. However, the molecular mechanisms underlying SM remain largely unexplored. The objective of this study was to identify molecular markers associated with SM in the epididymis of Zi geese (Anser cygnoides L.). The SM of 40 one-year-old ganders was assessed. Based on SM values, six ganders were selected: three with the highest SM (H group: n = 3, SM = 0.43 ± 0.02) and three with the lowest SM (L group: n = 3, SM = 0.10 ± 0.01, P < 0.001). Semen quality parameters, fertility, and hormone levels were measured in both groups. Epididymal tissues from the six ganders were subjected to transcriptomic and metabolomic analyses. Results identified 438 differentially expressed genes (DEGs) between the groups, primarily associated with transmembrane transport of proteins and ions. These DEGs were enriched in pathways such as "alanine, aspartate and glutamate metabolism," "butanoate metabolism," and the "PPAR signaling pathway." Among these, ATP12A, ATP1B4, and CNDP1 were identified as key genes regulating SM. Additionally, 486 metabolites showed significant differences between the groups in both positive and negative ion modes. Integration of transcriptomic and metabolomic data revealed critical gene-metabolite pairs, including CNDP1-citric acid, implicated in SM regulation. Notably, the "arginine biosynthesis" pathway was significantly enriched by both DEGs and differential metabolites. In conclusion, this study provides novel insights into the molecular mechanisms regulating SM in the epididymis and lays a theoretical foundation for geese breeding programs.

01 Apr 2025·American Journal of Physiology-Renal Physiology

Influence of carnosine supplementation on disease progression in a rat model of focal segmental glomerulosclerosis

Article

Author: Xu, Xin ; Hoffmann, Sigrid ; Qiu, Jiedong ; Hettler, Steffen ; Maihöfer, Tim ; Yard, Benito A. ; Schnell, Bero ; Krämer, Bernhard K. ; Pastene, Diego O.

In diabetic kidney disease models, carnosine supplementation ameliorates renal pathology, but its influence in other renal pathologies is less explored. We tested whether renal expression levels of carnosine system components correlate with disease in the model of the transgenic rat TGRNeph-hAT1 with sex-dependent focal segmental glomerulosclerosis and whether carnosine supplementation in male rats improves pathology. Our results provide evidence that carnosine feeding affects the glomerular hypertrophy and renal RAS expression.

01 Mar 2025·Life Sciences

Carnosinase inhibition enhances reactive species scavenging in high fat diet

Article

Author: Cotton, Daniel P ; Khatun, Suniya ; Lavilla, Charlie Jr ; Wallis, John D ; Sale, Craig ; Bhattacharya, Sreya ; Lee, Vivian K ; Turner, Mark D ; Billacura, Merell P ; Garner, A Christopher ; Caton, Paul W

AIMSLife expectancy is typically reduced by 2-4 years in people with a body mass index (BMI) of 30-35 kg/m² and by 8-10 years in people with a BMI of 40-50 kg/m². Obesity is also associated with onset, or exacerbation of, multiple chronic diseases. Mechanistically, this, in part, involves formation of advanced glycation and lipidation end-products that directly bond with proteins, lipids, or DNA, thereby perturbing typical cellular function. Here we seek to prevent these damaging adduction events through inhibition of carnosinase enzymes that rapidly degrade the physiological reactive species scavenger, carnosine, in the body.MAIN METHODSHerein we performed in silico computational modelling of a compound library of ∼53,000 molecules to identify carnosine-like molecules with intrinsic resistance to carnosinase turnover.KEY FINDINGSWe show that leading candidate molecules reduced reactive species in C2C12 myotubes, and that mice fed N-methyl-[6-(2-furyl)pyrid-3-yl]methylamine alongside a high fat diet had significantly decreased amounts of damaging plasma 4-hydroxynonenal and 3-nitrotyrosine reactive species. Oral administration of N-methyl-[6-(2-furyl)pyrid-3-yl]methylamine to high fat-fed mice also resulted in a modest ∼10 % reduction in weight gain when compared to mice fed only high fat diet.SIGNIFICANCEOur findings suggest that inhibition of carnosinase enzymes can increase the life-span, and thereby enhance the efficacy, of endogenous carnosine in vivo, thereby offering potential therapeutic benefits against obesity and other cardiometabolic diseases characterised by metabolic stress.

Analysis

Perform a panoramic analysis of this field.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

CNDP1

Basic Info

Related

Analysis