Synonyms GABA(A) receptor subunit alpha-5, GABA(A) receptor, alpha 5, GABRA5 + [3] |
Introduction Ligand-gated chloride channel subunit which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:29961870, PubMed:31056671). May be involved in GABA-A receptor assembly, and GABA-A receptor immobilization and accumulation by gephyrin at the synapse (PubMed:31056671). |
Target |
Mechanism GABRA5 modulators |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication- |
Drug Highest PhasePhase 2 |
First Approval Ctry. / Loc.- |
First Approval Date20 Jan 1800 |
Mechanism GABAA receptor modulators [+3] |
Active Org. |
Originator Org. |
Active Indication- |
Inactive Indication |
Drug Highest PhasePhase 1 |
First Approval Ctry. / Loc.- |
First Approval Date20 Jan 1800 |
Target |
Mechanism GABRA5 modulators |
Originator Org. |
Active Indication |
Inactive Indication- |
Drug Highest PhasePreclinical |
First Approval Ctry. / Loc.- |
First Approval Date20 Jan 1800 |
Start Date27 Jul 2023 |
Sponsor / Collaborator |
Start Date16 Dec 2022 |
Sponsor / Collaborator |
Start Date12 Mar 2019 |
Sponsor / Collaborator |