Last update 01 Nov 2024

SCNA x σ1 receptor x P-gp x NMDA receptor

Basic Info

Related Targets
SCNAσ1 receptorP-gp[+1]

Related

1
Drugs associated with SCNA x σ1 receptor x P-gp x NMDA receptor
Deudextromethorphan Hydrobromide/Quinidine Sulfate
Target
NMDA receptor x P-gp x SCNA x σ1 receptor
Mechanism
NMDA receptor antagonists [+3]
Active Org.
Otsuka Pharmaceutical Development & Commercialization, Inc.
Originator Org.
Concert Pharmaceuticals, Inc.Concert Pharmaceuticals, Inc.
Active Indication
Agitation [+1]
Inactive Indication
Aggression [+5]
Drug Highest PhasePhase 3
First Approval Ctry. / Loc.-
First Approval Date20 Jan 1800
16
Clinical Trials associated with SCNA x σ1 receptor x P-gp x NMDA receptor
NCT04464564 / Active, not recruitingPhase 3
A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Assess the Efficacy, Safety, and Tolerability of AVP-786 (deudextromethorphan Hydrobromide [d6-DM]/quinidine Sulfate [Q]) for the Treatment of Agitation in Patients with Dementia of the Alzheimer's Type
NCT04408755 / Active, not recruitingPhase 3
A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Assess the Efficacy, Safety, and Tolerability of AVP-786 (Deudextromethorphan Hydrobromide [d6-DM]/Quinidine Sulfate [Q]) for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type
NCT03896945 / TerminatedPhase 2/3
A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-arm Study to Assess the Efficacy, Safety, and Tolerability of AVP-786 (Deudextromethorphan Hydrobromide [d6-DM]/Quinidine Sulfate [Q]) for the Treatment of Negative Symptoms of Schizophrenia
100 Clinical Results associated with SCNA x σ1 receptor x P-gp x NMDA receptor
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100 Translational Medicine associated with SCNA x σ1 receptor x P-gp x NMDA receptor
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0 Patents (Medical) associated with SCNA x σ1 receptor x P-gp x NMDA receptor
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