Last update 19 Sep 2024

PLIN3

Last update 19 Sep 2024

Basic Info

Synonyms

47 kDa mannose 6-phosphate receptor-binding protein, 47 kDa MPR-binding protein, Cargo selection protein TIP47

+ [8]

Introduction

Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177).

Drugs associated with PLIN3

PLIN3 inhibitors (Maxim Pharmaceuticals)

Target

PLIN3

Mechanism

PLIN3 inhibitors

Active Org.

Maxim Pharmaceuticals, Inc.

Originator Org.

Maxim Pharmaceuticals, Inc.

Active Indication

Neoplasms

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with PLIN3

100 Translational Medicine associated with PLIN3

0 Patents (Medical) associated with PLIN3

808

Literatures (Medical) associated with PLIN3

01 Sep 2024·Metabolism open

Coffee pulp improves glucose and lipid metabolism disorder in high-fat diet-induced diabetic mice

Article

Author: Wang, Chenying ; Zhu, Shuaishuai ; Meng, Zhuo-Xian

Coffee berry extracts are anti-lipogenic and lipolytic.This study aims to investigate the effect and mechanism of coffee pulp on high-fat diet (HFD)-induced glucose and lipid metabolism disorder in mice.The type 2 diabetes (T2D) mouse model was established by feeding the C57BL/6 J mice with HFD.Mice were administered with coffee pulp diluted in drinking water before or after the establishment of the T2D mouse model.After treatment, the body weight and fasting blood glucose (FBG) of mice were monitored; the i.p. glucose tolerance test (IPGTT) of mice was performed; plasma insulin was determined by ELISA; serum total cholesterol (TC), triglyceride (TG) and liver TG were determined by biochem. anal.; hematoxylin-eosin (H&E) staining was used to evaluate organ histomorphol.Gene expression of key genes in de novo lipogenesis (DNL) in the liver was examined by quant. reverse transcription PCR (RT-qPCR).Mice that consumed coffee pulp after modeling showed reduced FBG and liver TG, improved IPGTT, and alleviated fatty liver.Consuming coffee pulp before modeling prevented HFD-induced blood glucose and plasma TG increases.Mice consuming coffee pulp also had lower body fat and liver TG compared to the model group. qPCR results showed that the expression of transcription factors (Srebp1, PPARγ) and genes (Fasn, CideA, Plin3, Plin4, Plin5) related to DNL and lipid droplets (LD) formation in the liver of mice consuming coffee pulp were significantly lower than those of the control group.Our study demonstrated that coffee pulp can attenuate HFD-induced disorders of glucose and lipid metabolism, and this effect may be related to the key pathways of lipid synthesis DNL and LD formation pathways in the liver.

01 Sep 2024·Metabolism Open

Coffee pulp improves glucose and lipid metabolism disorder in high-fat diet-induced diabetic mice

Article

Author: Wang, Chenying ; Zhu, Shuaishuai ; Meng, Zhuo-Xian

BackgroundCoffee berry extracts are anti-lipogenic and lipolytic. This study aims to investigate the effect and mechanism of coffee pulp on high-fat diet (HFD)-induced glucose and lipid metabolism disorder in mice.MethodsThe type 2 diabetes (T2D) mouse model was established by feeding the C57BL/6 J mice with HFD. Mice were administered with coffee pulp diluted in drinking water before or after the establishment of the T2D mouse model. After treatment, the body weight and fasting blood glucose (FBG) of mice were monitored; the intraperitoneal glucose tolerance test (IPGTT) of mice was performed; plasma insulin was determined by ELISA; serum total cholesterol (TC), triglyceride (TG) and liver TG were determined by biochemical analysis; hematoxylin-eosin (H&E) staining was used to evaluate organ histomorphology. Gene expression of key genes in de novo lipogenesis (DNL) in the liver was examined by quantitative reverse transcription PCR (RT-qPCR).ResultsMice that consumed coffee pulp after modeling showed reduced FBG and liver TG, improved IPGTT, and alleviated fatty liver. Consuming coffee pulp before modeling prevented HFD-induced blood glucose and plasma TG increases. Mice consuming coffee pulp also had lower body fat and liver TG compared to the model group. qPCR results showed that the expression of transcription factors (Srebp1, PPARγ) and genes (Fasn, CideA, Plin3, Plin4, Plin5) related to DNL and lipid droplets (LD) formation in the liver of mice consuming coffee pulp were significantly lower than those of the control group.ConclusionsOur study demonstrated that coffee pulp can attenuate HFD-induced disorders of glucose and lipid metabolism, and this effect may be related to the key pathways of lipid synthesis DNL and LD formation pathways in the liver.

15 Jun 2024·The FASEB Journal

Unraveling the role of lipid droplets and perilipin 2 in bovine luteal cells

Article

Author: Plewes, Michele R ; Cupp, Andrea S ; Talbott, Heather A ; Wood, Jennifer R ; Schott, Micah B ; Davis, John S

AbstractSteroidogenic tissues contain cytosolic lipid droplets that are important for steroidogenesis. Perilipin 2 (PLIN2), a structural coat protein located on the surface of lipid droplets in mammalian cells, plays a crucial role in regulating lipid droplet formation and contributing to various cellular processes such as lipid storage and energy homeostasis. Herein, we examine the role that PLIN2 plays in regulating progesterone synthesis in the bovine corpus luteum. Utilizing gene array databases and Western blotting, we have delineated the expression pattern of PLIN2 throughout the follicular to luteal transition. Our findings reveal the presence of PLIN2 in both ovarian follicular and steroidogenic luteal cells, demonstrating an increase in its levels as follicular cells transition into the luteal phase. Moreover, the depletion of PLIN2 via siRNA enhanced progesterone production in small luteal cells, whereas adenovirus‐mediated overexpression of both PLIN2 and Perilipin 3 (PLIN3) induced an increase in cytosolic lipid droplet accumulation and decreased hormone‐induced progesterone synthesis in these cells. Lastly, in vivo administration of the luteolytic hormone prostaglandin F2α resulted in an upregulation of PLIN2 mRNA and protein expression, accompanied by a decline in serum progesterone. Our findings highlight the pivotal role of PLIN2 in regulating progesterone synthesis in the bovine corpus luteum, as supported by its dynamic expression pattern during the follicular to luteal transition and its responsiveness to luteotropic and luteolytic hormones. We suggest PLIN2 as a potential therapeutic target for modulating luteal function.

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PLIN3

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