Synonyms GH receptor, GH-binding protein, GHBP + [7] |
Introduction The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling.
Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). |
Target |
Mechanism GHR agonists |
Active Org. |
Originator Org. |
Inactive Indication- |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. CA |
First Approval Date26 Oct 2021 |
Target |
Mechanism GHR agonists |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. US |
First Approval Date28 Aug 2020 |
Target |
Mechanism GHR agonists |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication- |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. CN |
First Approval Date02 Dec 2015 |
Start Date01 Jun 2025 |
Sponsor / Collaborator Columbia University [+2] |
Start Date05 Feb 2025 |
Sponsor / Collaborator |
Start Date15 Jan 2025 |
Sponsor / Collaborator |