Oct. 04, 2024 -- Kineta, Inc. (OTC Pink: KANT) , a clinical-stage biotechnology company focused on the development of novel immunotherapies in oncology that address cancer immune resistance, announced today that its abstract on the KVA12123 clinical program has been accepted for poster presentation at the Society for Immunotherapy of Cancer (SITC) 40th Annual Meeting to be held November 6-10, 2024, in Houston, Texas and virtually.
Thierry Guillaudeux, Ph.D., Chief Scientific Officer of Kineta, has announced that on November 8, 2024 Jason Henry M.D., Associate Director, Drug Development at Sarah Cannon Research Institute, Denver Colorado will be presenting the poster with new clinical data from an ongoing Phase 1/2 clinical trial on KVA12123, Kineta’s VISTA blocking immunotherapy, alone and in combination with Merck’s (known as MSD outside of the US and Canada) anti-PD-1 therapy, KEYTRUDA® (pembrolizumab) in patients with advanced solid tumors.
Presentation Details:
Title: A phase 1/2 clinical trial of antiVISTA – KVA12123 alone and in combination with pembrolizumab in patients with advanced solid tumors
Authors: Jason T Henry, MD1, Manish R. Patel, MD2, Paul L Swiecicki, MD3, Ida Micaily, MD4, Benjamin Garmezy, MD5, Kalyan Banda, MD6, Marya F Chaney, PhD7, Julia Cohen, MD7, Vinny Hayreh, MD8, Kurt Lustig, BS8, Yulia Ovechkina, PhD8, Evan Y Yu, MD6, Shawn P ladonato, PhD8, Thierry Guillaudeux, PhD8 and Lee Rosen, MD9,
(1) Sarah Cannon Research Institute at HealthONE, Denver, CO,
(2) Florida Cancer Specialists, Sarasota, FL,
(3) University of Michigan Rogel Cancer Center, Ann Arbor, MI,
(4) Thomas Jefferson University, Philadelphia, PA,
(5) Sarah Cannon Research Institute, Nashville, TN,
(6) Fred Hutchinson Cancer Center, Seattle, WA,
(7) Merck & Co., Inc., Rahway, NJ,
(8) Kineta, Inc., Seattle, WA,
(9) UCLA Medical Center, Los Angeles, CA.
Abstract Number: 625
Date / Time: Friday, November 8 at 9:00 A.M. – 7:00 P.M. Central Time
Location: Exhibit Halls AB – George R. Brown Convention Center, Houston, Texas
Abstract titles are now available on the SITC website. Posters will be made available on the Kineta website following presentations at the conference.
KEYTRUDA® is a registered trademark of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA.
Kineta is a clinical-stage biotechnology company with a mission to develop next-generation immunotherapies that transform patients’ lives. Kineta has leveraged its expertise in innate immunity and is focused on discovering and developing potentially differentiated immunotherapies that address the major challenges with current cancer therapy. The Company’s immuno-oncology pipeline includes KVA12123, a novel VISTA blocking immunotherapy currently in a Phase 1/2 clinical trial in patients with advanced solid tumors, and a preclinical monoclonal antibody targeting CD27. For more information on Kineta, please visit www.kinetabio.com.
Through the combination of unique epitope binding and an optimized IgG1 Fc region, KVA12123 has demonstrated strong tumor growth inhibition as both a monotherapy and in combination with other checkpoint inhibitors in preclinical models. KVA12123 provides a novel approach to address immune suppression in the tumor microenvironment with a mechanism of action that is differentiated and complementary with T cell focused therapies. KVA12123 may be an effective immunotherapy for many types of cancer including non-small cell lung (NSCLC), colorectal, renal cell carcinoma, head and neck, and ovarian cancer.
In February 2024, Kineta announced a significant corporate restructuring to substantially reduce expenses and preserve cash. The restructuring included a significant workforce reduction and the suspension of enrollment of new patients in its ongoing VISTA-101 Phase 1/2 clinical trial evaluating KVA12123 in patients with advanced solid tumors. At that time, Kineta also announced that it was exploring strategic alternatives to maximize stockholder value.
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