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Last update 08 May 2025

SEB

Last update 08 May 2025

Basic Info

Synonyms-

Introduction-

Drugs associated with SEB

MORAb-048

Target

SEB

Mechanism

SEB inhibitors

Active Org.

Morphotek, Inc. [+1]

Originator Org.

U.S. Army Medical Research Institute for Infectious Diseases

Active Indication

Staphylococcal Infections

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

CN116178534

Patent Mining

Target

SEB

Mechanism-

Active Org.

Third Military Medical University

Originator Org.

Third Military Medical University

Active Indication

Infectious Diseases [+1]

Inactive Indication-

Drug Highest PhaseDiscovery

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Aptamer Antagonist A11

Target

SEB

Mechanism

SEB inhibitors

Active Org.-

Originator Org.

900th Hospital of Joint Logistics Support Force of PLA

Active Indication-

Inactive Indication

Shock, Septic

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with SEB

100 Translational Medicine associated with SEB

0 Patents (Medical) associated with SEB

2,150

Literatures (Medical) associated with SEB

01 Jun 2025·Food Microbiology

Low temperature storage leads to advanced upregulation of typical virulence regulators, pyk and purR of enterotoxigenic Staphylococcus aureus cultured on chicken meat

Article

Author: Fan, Zhenzhen ; Wang, Huhu ; Xu, Xinglian ; Wang, Huawei ; Ma, Guangxia

Staphylococcal enterotoxins have long been studied due to the food-borne illness caused and complex intracellular virulence regulation involved. Along with the popularized application of cold chain production of meat products, there is important significance to explore the influence of low temperature on enterotoxin genes expression correlated to regulators under meat cultivation. In this study, SEA and SEB type Staphylococcus aureus strains (designated Sa08 and Sa13 respectively) were cultivated on chicken meat at 8 and 25 °C, typical virulence regulators (agrA, saeS, srrB, rot, codY and icaA), enterotoxins (sea and seb) and metabolic factors (pyk and pyruvate, purR and xanthosine monophosphate) were monitored. As a result, cell density remained stable (10⁴-10⁵ CFU/g) at 8 °C with slight increase in 6 day, and there were drastic pyruvate accumulation along with storing days. Significant upregulation of typical virulence regulators, pyk, purR and seb occurred in post exponential phase at 25 °C (p < 0.001). Nevertheless, phenotypic indexes failed to correspond to transcriptional changes. Expression of seb depended on the upregulation of typical virulence regulators at 8 and 25 °C, and sea had independent expression profile different from typical virulence regulators at 8 °C. Comparing with 25 °C, consistent advanced upregulation of typical virulence regulators (except codY of Sa08), pyk and purR were observed both for Sa08 and Sa13 at 8 °C, and different strains exhibited varied early metabolic response but similar later metabolic status at 8 °C. These phenomena highlighted a concern that, enterotoxigenic S. aureus colonizing on chicken meat exhibited advanced upregulation of typical virulence regulators and close-related virulence at low temperature.

15 Apr 2025·The Journal of Infectious Diseases

Patterns and Cofactors of Polyfunctional Mycobacteria-Specific T-Cell Response Restoration Following 6-Month Antiretroviral Treatment in Children With HIV

Article

Author: Cranmer, Lisa Marie ; Maleche-Obimbo, Elizabeth ; Escudero, Jaclyn N ; Mugo, Cyrus ; Lindestam Arlehamn, Cecilia S ; Sasser, Loren E ; Day, Cheryl L ; John-Stewart, Grace C ; Wamalwa, Dalton C ; Sette, Alessandro ; LaCourse, Sylvia M ; Pearson, Rachel A ; Njuguna, Irene N ; Okinyi, Hellen Moraa ; Whatney, Wendy E

AbstractBackgroundDespite immune restoration after initiation of antiretroviral treatment (ART), the risk of tuberculosis (TB) persists in children with HIV (CHIV). We determined patterns of immune restoration of mycobacteria-specific T cells following ART in CHIV.MethodsCD4 and CD8 T-cell activation and memory phenotype and functional profiles before and 6 months after ART were evaluated in peripheral blood mononuclear cells from CHIV enrolled in the PUSH study (NCT02063880) in Nairobi, Kenya. T-cell expression of cytokines and activation-induced markers were measured following stimulation of peripheral blood mononuclear cells with a pool of 300 peptides from TB (MTB300) or staphylococcal enterotoxin B.ResultsAmong 47 CHIV (median age, 1.5 years), staphylococcal enterotoxin B–induced Th1 cytokine+ and activation-induced marker+ CD4 cell frequencies increased significantly after 6 months of ART. Although MTB300-specific CD4 and CD8 cell frequency did not increase after ART, polyfunctional capacity of MTB300-specific CD4 cells expressing combinations of Th1 cytokines with CD40L increased significantly after ART. Baseline age, immune activation, and effector memory CD4 levels were associated with less restoration of MTB300-specific polyfunctional CD4 cells, whereas CD4 percentage and levels of naive CD4 cells following ART were associated with improved MTB300-specific polyfunctional capacity.ConclusionsDespite increases in Th1 cytokine production, deficits in mycobacteria-specific CD4 cells persisted 6 months after ART, with higher deficits in older CHIV with more immunosuppression, higher immune activation, and lower proportion of naive CD4 cells. These findings may explain persistent TB risk during early ART among CHIV and identify those at highest risk.

01 Apr 2025·Academic Pediatrics

Longitudinal Stability and Predictive Value of Socio/Emotional/Behavioral Screening in an Outpatient Pediatric Network

Article

Author: Hirshfeld-Becker, Dina R ; Holcomb Scarpelli, Juliana M ; Sheldrick, R Christopher ; Dutta, Anamika ; Boudreau, Alexy Arauz ; Birudavol, Justin ; Murphy, J Michael ; Jellinek, Michael S ; Perrin, Ellen C ; Carter, Alice S ; Benheim, Talia S

BACKGROUNDIn 2022, the American Academy of Pediatrics recommended annual social/emotional/behavioral (SEB) screening at preventive pediatric visits. Numerous SEB screeners have considerable empirical support for children of all ages. However, few studies inform the longitudinal use of SEB screeners in pediatrics.METHODSUsing electronic health records (EHR) from seven pediatric clinics in a large hospital system, we analyze the longitudinal stability of three SEB screeners among 9153 children and adolescents who were screened multiple times over a 3-year period, and we evaluate associations with International Classification of Disease (ICD) codes for SEB diagnoses.RESULTSModerate stability was documented for the Baby Pediatric Symptom Checklist (intraclass correlation coefficient [ICC]=.57), Preschool Pediatric Symptom Checklist (ICC=.60), and Pediatric Symptom Checklist-17 (ICC=.69). Stability of positive/negative results was sensitive to each screener's threshold. Across a range of thresholds that classify 7-20% of children as positive, all three screeners achieved positive predictive values (PPVs) of approximately 40-65% and diagnostic odds ratios ranging from 8 to 15. These findings compare favorably to published results for longer measures and structured interviews. Recommended thresholds varied markedly across screeners, and associations with ICD codes demonstrate that higher thresholds yield higher specificity but lower sensitivity (ie, a majority of ICD codes are not anticipated by positive screens).CONCLUSIONSThree common SEB screeners display longitudinal stability similar to longer, more established measures. Results demonstrate that recommended thresholds vary markedly across measures and that choice of threshold strongly influences sensitivity and specificity, underscoring the need for greater attention to selection of thresholds.

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SEB

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