Last update 08 May 2025

TRPC5

Basic Info

Synonyms
hTRP-5, hTRP5, PPP1R159
+ [8]
Introduction
Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:16284075, PubMed:38959890). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion. Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1 (By similarity). Acts on distinct neuronal populations in the hypothalamus to regulate innate behaviors including feeding, anxiety (flight/fight/fear), socialization, and maternal care (By similarity).

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