Last update 19 Sep 2024

PTPRD

Last update 19 Sep 2024

Basic Info

Synonyms

HPTP, protein tyrosine phosphatase receptor type D, Protein-tyrosine phosphatase delta

+ [4]

Introduction

Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2.

Drugs associated with PTPRD

Anti-PTPRD antibody(Cold Spring Harbor Laboratory)

Target

PTPRD

Mechanism

PTPRD inhibitors

Active Org.

Cold Spring Harbor Laboratory, Inc.

Originator Org.

Cold Spring Harbor Laboratory, Inc.

Active Indication

Breast Cancer

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with PTPRD

100 Translational Medicine associated with PTPRD

0 Patents (Medical) associated with PTPRD

438

Literatures (Medical) associated with PTPRD

01 Sep 2024·Nature Neuroscience

Cerebellar Purkinje neurons enhance thirst via asprosin–PTPRD signaling

Article

Independent of its appetite- and body weight-modulating effects, the hormone asprosin activates its receptor PTPRD at cerebellar Purkinje neurons to enhance thirst and maintain fluid homeostasis.Surprisingly, this has no effect whatsoever on Purkinje neuron-mediated motor coordination and learning.

01 Sep 2024·Nature Neuroscience

The cerebellum modulates thirst

Article

Author: Bailey, Samantha ; Sillitoe, Roy V ; Mishra, Ila ; Sharp, Alaina ; Kim, Linda H ; Bournat, Juan C ; He, Yanlin ; Poulton, Claire ; Chopra, Atul R ; Langsner, Amos ; Hahn, Abigayle ; Raza, Mir Abbas ; Basu, Bijoya ; Lin, Tao ; Sathyanesan, Aaron ; Moore, Amelia ; Feng, Bing ; Kim, Brian ; Brown, Amanda M

The cerebellum, a phylogenetically ancient brain region, has long been considered strictly a motor control structure. Recent studies have implicated the cerebellum in cognition, sensation, emotion and autonomic function, making it an important target for further investigation. Here, we show that cerebellar Purkinje neurons in mice are activated by the hormone asprosin, leading to enhanced thirst, and that optogenetic or chemogenetic activation of Purkinje neurons induces rapid manifestation of water drinking. Purkinje neuron-specific asprosin receptor (Ptprd) deletion results in reduced water intake without affecting food intake and abolishes asprosin's dipsogenic effect. Purkinje neuron-mediated motor learning and coordination were unaffected by these manipulations, indicating independent control of two divergent functions by Purkinje neurons. Our results show that the cerebellum is a thirst-modulating brain area and that asprosin-Ptprd signaling may be a potential therapeutic target for the management of thirst disorders.

02 Jul 2024·Proceedings of the National Academy of Sciences

Genomic structural variation contributes to evolved changes in gene expression in high-altitude Tibetan sheep

Article

Author: Li, Bowen ; Liu, Jianquan ; Kuang, Zhuoran ; Chen, Jiaqi ; Nevo, Eviatar ; Mao, Leyan ; Wan, Na ; Feng, Zhilong ; Wang, Yinjia ; Zhang, Yonglu ; Shen, Wei ; An, Xuan ; Wang, Huihua ; Storz, Jay F ; Duan, Qijiao ; Li, Kexin ; Bu, Yueting ; Liu, Sanyuan ; Miao, Weilan ; Liang, Xiaolong ; Yang, Xiaojie

Tibetan sheep were introduced to the Qinghai Tibet plateau roughly 3,000 B.P., making this species a good model for investigating genetic mechanisms of high-altitude adaptation over a relatively short timescale. Here, we characterize genomic structural variants (SVs) that distinguish Tibetan sheep from closely related, low-altitude Hu sheep, and we examine associated changes in tissue-specific gene expression. We document differentiation between the two sheep breeds in frequencies of SVs associated with genes involved in cardiac function and circulation. In Tibetan sheep, we identified high-frequency SVs in a total of 462 genes, including EPAS1 , PAPSS2 , and PTPRD . Single-cell RNA-Seq data and luciferase reporter assays revealed that the SVs had cis -acting effects on the expression levels of these three genes in specific tissues and cell types. In Tibetan sheep, we identified a high-frequency chromosomal inversion that exhibited modified chromatin architectures relative to the noninverted allele that predominates in Hu sheep. The inversion harbors several genes with altered expression patterns related to heart protection, brown adipocyte proliferation, angiogenesis, and DNA repair. These findings indicate that SVs represent an important source of genetic variation in gene expression and may have contributed to high-altitude adaptation in Tibetan sheep.

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PTPRD

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