Last update 01 Nov 2024

FGFRs x PDGFR x FLT3 x JAK x VEGFR x HPK1

Basic Info

Related Targets
FGFRsPDGFRFLT3[+3]

Related

1
Drugs associated with FGFRs x PDGFR x FLT3 x JAK x VEGFR x HPK1
Nefextinib
Target
FGFRs x FLT3 x HPK1 x JAK x PDGFR x VEGFR
Mechanism
FGFRs antagonists [+5]
Active Org.
Guangzhou Zaiji Medical Technology Co., Ltd.
Originator Org.
Guangzhou Zaiji Medical Technology Co., Ltd.
Active Indication
Advanced gastric carcinoma [+5]
Inactive Indication
Advanced Colorectal Adenocarcinoma [+5]
Drug Highest PhasePhase 2
First Approval Ctry. / Loc.-
First Approval Date20 Jan 1800
15
Clinical Trials associated with FGFRs x PDGFR x FLT3 x JAK x VEGFR x HPK1
NCT05425602 / Not yet recruitingPhase 1/2
A I / II Clinical Study to Evaluate the Safety, Tolerance, Pharmacokinetic Characteristics and Efficacy of MAX-40279 (Multi-target Tyrosine Kinase Inhibitor) Combined With KN046 (Anti-PD-L1 / CTLA-4 Bispecific Antibody) in Patients With Advanced / Metastatic Solid Tumors
CTR20220826 / Active, not recruitingPhase 2
一项评估MAX-40279（多靶点酪氨酸激酶抑制剂）联合KN046（抗PD-L1/CTLA-4双特异性抗体）在晚期/转移性实体瘤患者中的安全性、耐受性、药代动力学特征和有效性的I/II期临床研究
[Translation] A Phase I/II clinical study evaluating the safety, tolerability, pharmacokinetic characteristics and efficacy of MAX-40279 (a multi-targeted tyrosine kinase inhibitor) combined with KN046 (an anti-PD-L1/CTLA-4 bispecific antibody) in patients with advanced/metastatic solid tumors
CTR20220842 / Active, not recruitingPhase 1
评价MAX-40279-01联合特瑞普利单抗在实体瘤患者中的安全性、耐受性、药代动力学特征以及初步疗效的I期剂量探索研究
[Translation] A Phase I dose-finding study to evaluate the safety, tolerability, pharmacokinetic characteristics, and preliminary efficacy of MAX-40279-01 combined with toripalimab in patients with solid tumors
100 Clinical Results associated with FGFRs x PDGFR x FLT3 x JAK x VEGFR x HPK1
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100 Translational Medicine associated with FGFRs x PDGFR x FLT3 x JAK x VEGFR x HPK1
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0 Patents (Medical) associated with FGFRs x PDGFR x FLT3 x JAK x VEGFR x HPK1
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