Last update 01 Nov 2024

CMTM6

Basic Info

Synonyms
Chemokine-like factor superfamily member 6, CKLF like MARVEL transmembrane domain containing 6, CKLF-like MARVEL transmembrane domain-containing protein 6
+ [3]
Introduction
Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy.

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