Last update 01 Nov 2024

USP1

Basic Info

Synonyms
Deubiquitinating enzyme 1, hUBP, Ubiquitin carboxyl-terminal hydrolase 1
+ [7]
Introduction
Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995, PubMed:20147293). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029).

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