Last update 01 Nov 2024

D1 receptor x D2 receptor x μ opioid receptor x 5-HT2 receptor

Basic Info

Related Targets
D1 receptorD2 receptorμ opioid receptor[+1]

Related

1
Drugs associated with D1 receptor x D2 receptor x μ opioid receptor x 5-HT2 receptor
Samidorphan/olanzapine
Target
5-HT2 receptor x D1 receptor x D2 receptor x μ opioid receptor
Mechanism
5-HT2 receptor antagonists [+3]
Active Org.
Alkermes, Inc.
Originator Org.
Alkermes PlcAlkermes Plc
Active Indication
Bipolar I disorder [+2]
Inactive Indication
Alcohol Use Disorder
Drug Highest PhaseApproved
First Approval Ctry. / Loc.
US
First Approval Date28 May 2021
21
Clinical Trials associated with D1 receptor x D2 receptor x μ opioid receptor x 5-HT2 receptor
NCT06649214
/ Not yet recruitingPhase 3
A Randomized, Double-blind, Double-dummy, Positive Drug Parallel Controlled Phase III Clinical Study to Evaluate the Safety and Efficacy of Olanzapine-Samidorphan Tablets in Adults With Schizophrenia
NCT05547100
/ CompletedPhase 1
A Phase 1, Open-Label Study of the Breast Milk Pharmacokinetics of Olanzapine and Samidorphan in Healthy Lactating Women
NCT05303064
/ RecruitingPhase 3
A Phase 3, Randomized, Double-Blind, 52-Week Study of OLZ/SAM Vs Olanzapine to Evaluate Weight Gain As Assessed by Change in BMI Z-Score in Pediatric Subjects with Schizophrenia or Bipolar I Disorder (ENLIGHTEN-Youth)
100 Clinical Results associated with D1 receptor x D2 receptor x μ opioid receptor x 5-HT2 receptor
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100 Translational Medicine associated with D1 receptor x D2 receptor x μ opioid receptor x 5-HT2 receptor
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0 Patents (Medical) associated with D1 receptor x D2 receptor x μ opioid receptor x 5-HT2 receptor
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