[Translation] An open-label, multicenter, first-in-human Phase I study evaluating the safety, tolerability, pharmacokinetics, and preliminary antitumor activity of SIM0686 in adult subjects with locally advanced/metastatic solid tumors
第 1 部分剂量递增:确定最大耐受剂量(MTD) 和/或推荐剂量(RD),评价SIM0686的安全性和耐受性。第 2 部分队列扩展:初步评价SIM0686的抗肿瘤活性。
[Translation] Part 1 Dose escalation: Determine the maximum tolerated dose (MTD) and/or recommended dose (RD) and evaluate the safety and tolerability of SIM0686. Part 2 Cohort expansion: Preliminary evaluation of the anti-tumor activity of SIM0686.