Last update 01 Nov 2024

GRB2

Basic Info

Synonyms
GRB2衔接蛋白质, Adapter protein GRB2, ASH
+ [6]
Introduction
Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.

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