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Last update 23 Jan 2025

SERPINB2

Last update 23 Jan 2025

Basic Info

Synonyms

HsT1201, Monocyte Arg-serpin, PAI-2

+ [8]

Introduction

Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1.

Drugs associated with SERPINB2

SG-500455

Target

PAI-1 x SERPINB2

Mechanism

PAI-1 inhibitors [+3]

Active Org.

Second Genome, Inc.

Originator Org.

Second Genome, Inc.

Active Indication

Inflammatory Bowel Diseases

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

CN118557734

Patent Mining

Target

SERPINB2

Mechanism

SERPINB2 inhibitors

Active Org.

Zhongshan Ophthalmic Center

Originator Org.

Zhongshan Ophthalmic Center

Active Indication

Eye Diseases [+1]

Inactive Indication-

Drug Highest PhaseDiscovery

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with SERPINB2

100 Translational Medicine associated with SERPINB2

0 Patents (Medical) associated with SERPINB2

1,294

Literatures (Medical) associated with SERPINB2

01 Jan 2025·Molecular biology research communications

Dysregulated genes in HIGK-treated F. nucleatum and their possible association with HNSCC.

Article

Author: Anitha, P ; Vijayashree Priyadharsini, J ; Smiline Girija, A S ; Shanmugam, S B ; Paramasivam, A

The present study aims to identify the differentially expressed genes in HIGK treated with Fusobacterium nucleatum (Fn) and their possible role in establishing head and neck squamous cell carcinoma. The study design follows a computational approach wherein multiple databases and tools are used to derive the possible association between Fn exposure and the development of HNSCC. The GEOmnibus dataset GSE6927 provided data on the differentially expressed genes in the HIGK treated with Fn. The GEO2R analysis revealed 22 differentially expressed genes in HIGK cells treated with Fn. The expression profile of these genes was then analyzed in the HNSCC (TCGA, Firehose Legacy) dataset employing the UALCAN database. The present study revealed 5 genes viz., GSDMD, NUP214, ZNF426, FUT2, and SERPINB2 exhibiting similar expression patterns in Fn-treated HIGK and HNSCC datasets. The GSDMD and NUP214 were found to be upregulated, and the genes ZNF426, FUT2, and SERPINB2 were downregulated. Among the five genes, the ZNF426 demonstrated a significant association with the survival of HNSCC patients. The low expression of ZNF426 presented a poor prognosis compared to the high expression. The study's results identified ZNF426 as a candidate gene involved in Fusobacterium nucleatum infection and HNSCC. Validating this result is necessary to gain insights into the role of the ZNF426 gene in developing HNSCC. Furthermore, probing the epigenetic factors targeting ZNF426 can be a potential therapeutic lead.

01 Jan 2025·International Journal of Biological Sciences

Advanced Lung-on-a-Chip Technology: Mimicking the Complex Human Lung Microenvironment

Article

Author: Lee, Choon-Mi ; Lee, Hwa-Yong ; Oh, Byung-Chul ; Park, Chan Hum ; Jung, YunJae ; Lee, Jin Woo ; Kim, Soo-Rim ; Min, Eun-Kyung

Intricate crosstalk among various lung cell types is crucial for orchestrating diverse physiological processes. Traditional two-dimensional and recent three-dimensional (3D) assay platforms fail to precisely replicate these complex communications. Many in vitro lung models do not effectively reflect the multicellular complexity of lung tissue. Here, we fabricated an advanced multicellular 3D lung-on-a-chip system that properly replicates the dynamic pulmonary microenvironment and its intricate microarchitecture. Diverse lung cells were incorporated into a microstructure formed from a mixture of natural polymers, including collagen and hyaluronic acid, and blood coagulation factors acting as natural crosslinking agents. The system accurately reflects the complex 3D architecture of the lung. Biomarkers demonstrate more rapid and sensitive responses to toxic substances than functional indicators, such as cell proliferation and apoptosis. SERPINB2 was identified as a biomarker of lung toxicity; it was activated in small airway epithelial cells exposed to various toxic substances. We then developed a fluorescence-linked toxicity biomarker screening platform that enables both intuitive and quantitative evaluation of lung toxicity by measuring the converted fluorescent signal strength. This fluorescent tagging system was incorporated into small airway epithelial cells within a fabricated chip platform; enabling lung-on-a-chip enabled evaluation of the lung toxicity of prospective drug candidates.

01 Dec 2024·Dental Traumatology

Outcomes of apexification in immature traumatised necrotic teeth and risk factors for premature tooth loss: A 20‐year longitudinal study

Article

Author: Anderson, Maria ; Wikström, Alina ; Brundin, Malin ; Tsilingaridis, Georgios ; Mohmud, Afrah

AbstractBackground/AimTo evaluate the long‐term survival of immature traumatized incisors with pulp necrosis and apical periodontitis after endodontic treatment with two apexification techniques (calcium hydroxide apexification and MTA‐apical plug) and to identify major factors affecting the survival of these teeth.Materials and MethodsRecords of 2400 children and adolescents were screened for presence of traumatic dental injuries to immature incisors where endodontic treatment with the two apexification techniques was performed during January 2003 and December 2022, compared to a control group of mature teeth treated with conventional endodontic techniques. The studied variables were age; sex; apexification technique, presence of luxation and hard tissue injuries; preoperative root development stage (RDS), preoperative and postoperative periapical index (PAI), the time‐point for tooth loss, and overall survival time in years. Kaplan–Meier estimates were used to graphically present the survival functions and Cox proportional hazard model to calculate hazard ratios (HR, 95% CI).ResultsThe median survival time was 10 years for calcium hydroxide apexification, 16.1 for MTA‐apexification, for luxation injuries other than intrusions and avulsions 15.5 years, for intrusions 12.5 years and for avulsions 6.8 years. The variables with significant negative impact on tooth survival were calcium hydroxide apexification, avulsion and postoperative PAI 3–5. No significant relationships were found for the variables MTA apexification, concussion; subluxation; lateral luxation; extrusion, intrusion, hard tissue injuries, preoperative RDS and PAI scores and postoperative PAI 1–2. After adjustment, the risk for premature tooth loss was 13.5 times higher in calcium hydroxide apexification, approximately 2 to 4 times higher in PAI 3–5, and 5.6 times higher in avulsions.ConclusionsCalcium hydroxide apexification, avulsion, and postoperative PAI 3–5 were identified as prognostic variables with significant negative impact on the risk for premature tooth loss.

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