enteropeptidase

'Beyond Structure, Predicting Function' SHANGHAI, Dec. 25, 2024 /PRNewswire/ -- Recently, Shanghai Matwings Technology Co., Ltd. ('Matwings'), a global leader in AI-driven protein design, announced the successful completion of Series A funding rounds, raising tens of millions of USD, led by Qiming Venture Partners. Matwings is pioneering a new frontier in protein engineering with its proprietary AI-based general protein design platform, AccelProtein™, which directly predicts protein functionality beyond the structural data. By predicting functionality, AccelProtein™ offers a new approach for acquiring high-functioning proteins. AccelProtein™ is built on the Pro-PRIME model, a breakthrough developed by a collaborative team led by Professor Liang Hong at Shanghai Jiao Tong University. After years of research focused on data collection, curation, and optimization, the team developed the Pro-series - an AI framework for protein design. Their work, titled "A General Temperature-Guided Language Model to Design Proteins of Enhanced Stability and Activity" was recently published in Science Advances. A featured case of AccelProtein™'s impact is the design of a specialized Glycosyltransferase enzyme, which is used in the production of EPS-G7, a core material for pancreatitis screening. Within just 4 months, Matwings increased the enzyme's total glycosylation activity by 7 times, enhanced product specificity from 60% to 98%, and reduced hydrolytic activity by 33%. These improvements cut down the cost of EPS-G7 by 90%. In another application, Matwings successfully engineered a super alkali-resistant affinity ligand (a nanobody) for affinity chromatography, improving alkali resistance by 3 folds, binding capacity over 100%, and heat stability by 8℃. This innovation saved millions of USD in CMC costs for a Matwings client. Additionally, scale-up production to 5000L has been successfully completed. Such advancement enables low-cost affinity chromatography purification a viable option for a wide range of biologics, bringing more cost-effective solutions for drug production. Since 2021, Matwings has successfully delivered over 30 protein-engineering and enzyme-mining projects either proprietary (e.g., Enterokinase, Carboxypeptidase B, KEX2 Protease, Maltogenic Amylase, Subtilisin, Protein A, PETase, T7 RNA Polymerase, and phi29 DNA Polymerase) and co-developed with our stakeholders. These projects span across various applications, including drug innovation, in vitro diagnostics, nutrition and healthcare, food and beverage, and green energy. About Matwings Matwings, founded in 2021 by an elite team from Shanghai Jiao Tong University, is one of the earliest companies to focus on AI protein models. Matwings is dedicated to moving beyond directed evolution methods to design and engineer functionally optimized proteins by leveraging a proprietary, pre-trained, AI-based general protein design platform with 780 million curated full-length protein sequence data, including nearly 500 million private data. This cutting-edge technology platform, AccelProtein™, enables us to engineer proteins and uncover or de novo design novel proteins with significantly improved properties, including stability, activity, affinity, yield, etc. To date, Matwings has successfully engineered more than 30 proteins either proprietary or co-developed with its stakeholders, and more than 40 ongoing projects across various applications in pharmaceutical industries and synthetic biology industries, e.g. key enzymes and proteins for CMC, innovative Biologics, synthetic biology and more. Matwings is actively seeking global partnerships to jointly develop and commercialize new products. Contact Information: Email: [email protected] Website: Tel: +86 158 2106 5410 Paper Link: SOURCE Matwings Technology WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

Paras Biopharmaceuticals Finland Oy is named as One of the Top 30 Admired Companies to Watch 2021 Oulu, Finland 28th April, 2021: – PARAS BIOPHARMACEUTICALS FINLAND OY, a fast-growing, biopharmaceutical technology development company, based in Oulu, Finland, announced today that it is named as one of the top 30 admired companies to watch during 2021, by CIO Bulletin, USA. This selection highlights the company's notable development and production of complex biologics using Paras Biopharmaceuticals' cutting-edge technologies, thus providing solutions with which to make healthcare more cost-efficient. Paras Biopharmaceuticals is proud to have been selected as it highlights the significance in the development and production of the authentic biologics work it carries out, using their proprietary and novel technologies. Located in the innovative and technology-advanced city of Oulu, Finland, Paras Biopharmaceuticals brings together a unique mix of world-class microbial biologics development technologies and a sound understanding of customer needs for the development and production of recombinant biologics. The top-30 list is published by the innovative news editorial company CIO Bulletin - a pioneering platform that encapsulates company achievements, novel technologies and identifies best practices. With a strong viewership/circulation of over 700 thousand decision-makers and print copies of 77,000 per issue, CIO Bulletin is one of the best covered facilitators in delivering innovative editorial content that keeps readers interested to know more. "We appreciate the recognition from CIO Bulletin on the efforts by the Paras Biopharmaceuticals team on its technological innovations within biologics manufacturing", says Dr Mark Jackson, Administration Lead. "Our objective is to develop and provide unique solutions for complex biologics for affordable healthcare and rare & orphan diseases (un-met medical needs). Being identified validates efforts made by the company. We thank CIO Bulletin for the recognition", adds CEO, Dr. Ashesh Kumar About Paras Biopharmaceuticals Finland Oy: Paras Biopharmaceuticals Finland Oy started in 2013 whose team comprises of protein scientists, bioprocess engineers and technologists. The Paras Biopharmaceuticals' team has strong experience in developing biologics in the most efficient manner. Company main activities & offerings are in 3 major areas: 1. Contract development & microbial biologics manufacturing (CDMO). 2. Development of Recombinant expression systems and process technologies for biologics and biosimilars. 3. Recombinant Bioprocess Enzymes – TEV protease and Recombinant Enterokinase. Paras Biopharmaceuticals has a fully equipped microbial production facility in Finland for the production of recombinant therapeutic products. With a total floor area of 25,000 ft2 and a classified cleanroom of 4,300 ft2, other features include media and buffer preparation, live area (fermentation and harvest & extraction), purification suite (incl. +4°C cold room), final filtration and freeze-drying. Paras Biopharmaceuticals has a strong pipeline of Biologics & Biosimilars in Osteoporosis, Rheumatoid Arthritis, Oncology and Metabolic Diseases. For more information, please see the company pipeline: Click here Direct Link to the article: Click here For further information, please contact: Media Relations & Information Dr Mark Jackson Tel: +358 442709462 Email: mark.jackson@parasbiopharma.com