Last update 01 Nov 2024

EZR

Last update 01 Nov 2024

Basic Info

Synonyms

Cytovillin, EZR, ezrin

+ [3]

Introduction

Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.

100 Clinical Results associated with EZR

100 Translational Medicine associated with EZR

0 Patents (Medical) associated with EZR

2,428

Literatures (Medical) associated with EZR

31 Dec 2024·Bioengineered

Statement of Retraction: Long non-coding RNA taurine up regulated 1 promotes osteosarcoma cell proliferation and invasion through upregulating Ezrin expression as a competing endogenous RNA of micro RNA-377-3p

01 Dec 2024·Cellular and Molecular Life Sciences

VEGFD signaling balances stability and activity-dependent structural plasticity of dendrites

Article

Author: Mauceri, Daniela ; Missirlis, Dimitris ; Sánchez Romero, Javier ; Yan, Jing ; Aksan, Bahar ; Kenkel, Ann-Kristin

AbstractMature neurons have stable dendritic architecture, which is essential for the nervous system to operate correctly. The ability to undergo structural plasticity, required to support adaptive processes like memory formation, is still present in mature neurons. It is unclear what molecular and cellular processes control this delicate balance between dendritic structural plasticity and stabilization. Failures in the preservation of optimal dendrite structure due to atrophy or maladaptive plasticity result in abnormal connectivity and are associated with various neurological diseases. Vascular endothelial growth factor D (VEGFD) is critical for the maintenance of mature dendritic trees. Here, we describe how VEGFD affects the neuronal cytoskeleton and demonstrate that VEGFD exerts its effects on dendrite stabilization by influencing the actin cortex and reducing microtubule dynamics. Further, we found that during synaptic activity-induced structural plasticity VEGFD is downregulated. Our findings revealed that VEGFD, acting on its cognate receptor VEGFR3, opposes structural changes by negatively regulating dendrite growth in cultured hippocampal neurons and in vivo in the adult mouse hippocampus with consequences on memory formation. A phosphoproteomic screening identified several regulatory proteins of the cytoskeleton modulated by VEGFD. Among the actin cortex-associated proteins, we found that VEGFD induces dephosphorylation of ezrin at tyrosine 478 via activation of the striatal-enriched protein tyrosine phosphatase (STEP). Activity-triggered structural plasticity of dendrites was impaired by expression of a phospho-deficient mutant ezrin in vitro and in vivo. Thus, VEGFD governs the equilibrium between stabilization and plasticity of dendrites by acting as a molecular brake of structural remodeling.

04 Nov 2024·Journal of Cell Biology

Coordination of force-generating actin-based modules stabilizes and remodels membranes in vivo

Article

Author: Galeano Niño, Jorge Luis ; Heydecker, Marco ; Bhardwaj, Abhishek ; Shitara, Akiko ; Narayan, Kedar ; Ebrahim, Seham ; Appaduray, Mark A. ; Weigert, Roberto ; Hardeman, Edna C. ; Tora, Muhibullah S. ; Tran, Duy T. ; Gunning, Peter W. ; Masedunskas, Andrius ; Chen, Desu

Membrane remodeling drives a broad spectrum of cellular functions, and it is regulated through mechanical forces exerted on the membrane by cytoplasmic complexes. Here, we investigate how actin filaments dynamically tune their structure to control the active transfer of membranes between cellular compartments with distinct compositions and biophysical properties. Using intravital subcellular microscopy in live rodents we show that a lattice composed of linear filaments stabilizes the granule membrane after fusion with the plasma membrane and a network of branched filaments linked to the membranes by Ezrin, a regulator of membrane tension, initiates and drives to completion the integration step. Our results highlight how the actin cytoskeleton tunes its structure to adapt to dynamic changes in the biophysical properties of membranes.

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EZR

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