Last update 21 Mar 2024

CAPN1

Calpain 1

Basic Info

Synonyms
Calcium-activated neutral proteinase 1, calpain 1, calpain 1, (mu/I) large subunit
+ [11]
Introduction
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction (PubMed:19617626, PubMed:21531719, PubMed:2400579). Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409' (PubMed:23707407). Cleaves and activates caspase-7 (CASP7) (PubMed:19617626).

Analysis

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