Last update 08 May 2025

NaPi-2a

Basic Info

Synonyms
Na(+)-dependent phosphate cotransporter 2A, Na(+)/Pi cotransporter 2A, Na+-phosphate cotransporter type II
+ [15]
Introduction
Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane (PubMed:12324554, PubMed:20335586, PubMed:26047794, PubMed:8327470). The cotransport has a Na(+):Pi stoichiometry of 3:1 and is electrogenic (By similarity).

Related

1
Drugs associated with NaPi-2a
PF-06869206
Target
NaPi-2a
Mechanism
NaPi-2a blockers
Active Org.-
Originator Org.
Pfizer Inc.Pfizer Inc.
Active Indication-
Inactive Indication
Cardiovascular Diseases
Drug Highest PhaseDiscontinued
First Approval Ctry. / Loc.-
First Approval Date20 Jan 1800
100 Clinical Results associated with NaPi-2a
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100 Translational Medicine associated with NaPi-2a
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0 Patents (Medical) associated with NaPi-2a
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318
Literatures (Medical) associated with NaPi-2a
01 May 2025American Journal of Physiology-Renal Physiology
Prolonged unilateral renal ischemia-reperfusion as a model for acute to chronic kidney injury in female mice
01 Apr 2025Physiological Reports
Partial renal deletion of Klotho is not sufficient to impact renal electrolyte handling in distal convoluted tubule specific knock‐out mice
01 Feb 2025Journal of Pediatric Urology
Editorial commentary to CASR, CLDN 14, ALPL & SLC34A1 genes are associated with the risk of nephrolithiasis in Egyptian children

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