A Phase I/IIa Open Label, Non-Randomized, Multicenter Study of CYNK-101 in Combination with Trastuzumab and Pembrolizumab in Patients with Locally Advanced Unresectable or Metastatic HER2-Positive Gastric or Gastroesophageal Junction (G/GEJ) Aenocarcinoma

This study will find the maximum tolerated dose (MTD) of CYNK-101 which contains Natural Killer (NK) cells derived from human placental CD34+ cells and culture-expanded. CYNK-101 will be administered as first-line treatment, following induction therapy consisting of Pembrolizumab, Trastuzumab and a Fluoropyrimidine / Platinum based Chemotherapy regimen. Patients are required to undergo a biopsy for confirmation of HER2 positivity defined as either IHC 3+ or IHC 2+ with a positive fluorescent in-situ hybridization (FISH) or FISH + alone. The safety of this treatment will be evaluated, and researchers will want to learn if NK cells will help in treating patients with Locally Advanced Unresectable or Metastatic HER2-Positive Gastric or Gastroesophageal Junction (G/GEJ) Adenocarcinoma.

Start Date14 Apr 2022

Sponsor / Collaborator

Celularity, Inc.

100 Clinical Results associated with FcRIII

100 Translational Medicine associated with FcRIII

0 Patents (Medical) associated with FcRIII

133

Literatures (Medical) associated with FcRIII

01 Oct 2020·Journal of Cellular PhysiologyQ2 · BIOLOGY

M2 differentiation of MonoMac‐1 cell line induced by M‐CSF and glucocorticoid pathways

Q2 · BIOLOGY

Article

Author: Rappaport, Jay ; Fischer, Tracy ; Vakili, Sarah

AbstractModels of macrophage subtypes require molecular characterization to reliably facilitate their differentiation. Although CD16+ (Fc‐gamma III receptor) monocytes that express CD163 (a hemoglobin/haptoglobin receptor) have been implicated in a variety of disease states, the conditions necessary to establish lineages of these cell subtypes remains unknown. The current investigations utilize a cell line derived from acute myelogenous leukemia lineage, MonoMac‐1, to interrogate the factors that promote the development of CD16+ macrophages that express CD163. Results implicate the glucocorticoid pathway as well as c‐fms signaling based on the action of dexamethasone and macrophage colony‐stimulating factor‐1 in promoting CD16+ expression, in addition to phorbol myristate acetate and lipopolysaccharides treatment. The ability of glucocorticoid and c‐fms receptor antagonists to inhibit CD16+ cell formation further establishes the role of these pathways in CD16 expression in this cell line. In view of the inherent difficulty in working with primary cells as well as donor variation, cell lines may be preferable to primary cells for their consistency. We envision that the process we use to induce CD16 expression in this cell type will be useful for screening and identification of drug candidates potentially useful for the treatment of diseases where the etiology involves the expansion of the CD16+ monocytes subset or the accumulation of CD163+ tissue macrophages.

20 Jul 2020·Russian Clinical Laboratory Diagnostics

CHROMATO-MASS SPECTROMETRIC ANALYSIS OF URINE PROTEINS ASSOCIATED WITH THE FUNCTIONS OF TOLL-RECEPTORS IN A HEALTHY PERSON UNDER CONDITIONS OF 17-DAY ISOLATION

Article

Author: Goncharova, A. G. ; Orlova, K. D. ; Pastyshkova, L. Kh. ; Zakharova, N. B. ; Brzhozovsky, A. G. ; Larina, I. M. ; Morozova, O. L. ; Goncharov, I. N. ; Ponomarev, S. A. ; Kashirina, D. N.

Under controlled conditions of 17-day isolation (Sirius-17 experiment), the protein composition of urine was studied in 6 healthy test volunteers-3 women and 3 men. Collection of samples in the form of a second freely separated morning urine fraction was carried out in the background (seven days before the experiment), as well as 1 day after the end of exposure. Chromatographic-mass-spectrometric semi-quantitative analysis of the protein composition of samples was performed on a system consisting of an Agilent 1100 chromatograph and an LTQ-FT Ultra hybrid mass spectrometer using bioinformatics resources UniProtKB, GeneOntology. An asymptomatic change in the immune defense system of kidney tissue after isolation in a closed hermetic object is associated with a change in the content of 7 proteins that provide functional activity of the TLR tubules of the kidneys - FcRIII, MUC1, Galectin-3, Ficolin-2, APOA1, FLNA, FCGR3A and Clusterin. These proteins are found to be useful biomarkers in the study of physiology and kidney diseases. They can be attributed to candidates for protein markers of the initial stages of impaired recognition by the epithelium of renal tubules of bacteria with known pathogenic potential.

01 Jan 2020·Gastroenterology and hepatology from bed to bench

Evaluation of CXCR1 as a possible diagnostic biomarker in acute appendicitis.

Article

Author: Ensieh Khalkhal ; Majid Rezaei-Tavirani ; Zahra Razzaghi ; Mostafa Rezaei-Tavirani ; Nosratollah Naderi ; Alireza Akbarzadeh Baghban

AIMThe present study was conducted to determine the genes with common expression in blood and appendix tissue samples in order to introduce them as possible diagnostic biomarkers.BACKGROUNDDiagnosis of acute appendicitis (AA) without applying computed tomographytomography (CT), subjecting the patient to significant radiation, can be surprisingly difficult. Blood circulation may have conscious alterations in its RNA, protein, or metabolite composition.METHODSThe genes related to appendix tissue and blood samples of the patients with AA were extracted from public databases. Fold change (FC) ≥ 2 in blood and FC ≥ 5 in appendix tissue samples were considered to screen differentially expressed genes (DEGs). A protein-protein interaction network was organized using the search tool for retrieval of interacting genes and proteins (STRING) database as a plugin of Cytoscape software version 3.6.0. The main genes were enriched by DAVID Bioinformatics Resources to find the related biochemical pathways.RESULTSAmong the DEGs in blood and appendix tissue samples, C-X-C motif chemokine receptor 1(CXCR1), leukocyte immunoglobulin-like receptor A3 (LILRA3), low-affinity immunoglobulin gamma Fc region receptor III (FCGR3), and superoxide dismutase 2(SOD2) were common in both sources. CXCR1 was found as only hub gene upregulated in both blood and tissue of the patients with AA compared to controls and those with other abdominal pain.CONCLUSIONCXCR1, FCGR3, LILRA3, and SOD2 were determined as a suitable possible biomarker panel for diagnosis of AA disease.

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