Last update 08 May 2025

ASTE1

Basic Info

Synonyms
ASTE1, asteroid homolog 1, HT001
+ [1]
Introduction
Structure-specific DNA endonuclease that specifically cleaves single-stranded DNA and 3' overhang DNA. Contributes to the control of DNA double-strand break repair choice by antagonizing BRCA1-dependent homologous recombination (HR) and promoting non-homologous end-joining (NHEJ). Recruited to the single-stranded DNA ends by SHLD2 and cleaves the 3' exposed DNA ends, therefore inhibiting DNA end resection (necessary for HR) and promoting DNA end protection (necessary for NHEJ).

Related

2
Drugs associated with ASTE1
FMPV-3
Target
ASTE1 x TAF1B x TGFBR2
Mechanism
ASTE1 modulators [+2]
Active Org.
Hubro Therapeutics ASHubro Therapeutics AS
Originator Org.
Hubro Therapeutics ASHubro Therapeutics AS
Active Indication
Hereditary Nonpolyposis Colorectal Cancer
Inactive Indication-
Drug Highest PhasePreclinical
First Approval Ctry. / Loc.-
First Approval Date20 Jan 1800
FMPV-2
Target
ASTE1
Mechanism
ASTE1 modulators [+1]
Active Org.
Hubro Therapeutics ASHubro Therapeutics AS
Originator Org.
Hubro Therapeutics ASHubro Therapeutics AS
Active Indication
Endometrial Carcinoma
Inactive Indication
Colorectal Cancer
Drug Highest PhasePreclinical
First Approval Ctry. / Loc.-
First Approval Date20 Jan 1800
100 Clinical Results associated with ASTE1
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100 Translational Medicine associated with ASTE1
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0 Patents (Medical) associated with ASTE1
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15
Literatures (Medical) associated with ASTE1
01 Aug 2021Nature Cell Biology
ASTE1 promotes shieldin-complex-mediated DNA repair by attenuating end resection
01 Aug 2021Nature Cell Biology
ASTE1 cutting to block DNA end resection
01 Sep 2020Clinical Cancer Research
A Frameshift Peptide Neoantigen-Based Vaccine for Mismatch Repair-Deficient Cancers: A Phase I/IIa Clinical Trial

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