On January 24, 2024, Novo Nordisk entered into a potential collaboration and licensing agreement with EraCal Therapeutics to jointly develop a new mechanism of action drug for the control of appetite and body weight.
Under the terms of the agreement, Novo Nordisk has obtained all exclusive rights to develop and commercialize EraCal's oral small molecule drugs for the treatment of obesity; EraCal is expected to receive up to 235 million euros ($255 million) in upfront, development, and commercial milestones payments, as well as royalties on sales after product launch.
The two companies initially came together in January 2022 to collaborate on the research of new anti-obesity drug targets related to the regulation of food intake and other metabolic phenotypes.
The drug Era-379 is a small molecule drug that falls under the therapeutic areas of endocrinology and metabolic disease. Its active indication is obesity, suggesting that it is being developed to address this specific condition. The drug is being developed by EraCal Therapeutics AG, which is the originator organization responsible for its development. Click the image below to directly embark on the exploration journey with the Era-379!
Currently, Era-379 has entered the preclinical stage. Trial results have shown that with just once-daily oral administration of Era-379, obese mice experienced a weight reduction of at least 20% within two weeks.
EraCal Therapeutics was founded in 2018 and is dedicated to the research and development of safe and effective anti-obesity drugs through a zebrafish phenotypic screening platform. The company aims to address the issue of obesity in patients and prevent complications arising from the condition.
The company is a spin-off from research conducted at the University of Zurich and Harvard University, co-founded by Dr. Josua Jordi and Simon Breitler. Dr. Jordi has nearly a decade of research experience in the field of appetite suppressants.
As early as 2019, the company had already completed a seed funding round, raising an amount of 6 million Swiss francs.
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