Yes, Belzutifan is FDA approved. The U.S. Food and Drug Administration (FDA) approved Belzutifan on August 13, 2021, for the treatment of adult patients with von Hippel-Lindau (VHL) disease who require therapy for associated renal cell carcinoma (RCC), central nervous system (CNS) hemangioblastomas, or pancreatic neuroendocrine tumors (pNET) that do not require immediate surgery.
Belzutifan is specifically designed to treat tumors associated with VHL disease in adults. VHL is a genetic disorder characterized by the formation of tumors and cysts in different parts of the body, including the kidneys, pancreas, and central nervous system. Belzutifan works by inhibiting hypoxia-inducible factor-2 alpha (HIF-2α), which is involved in the growth of these tumors.
Belzutifan is administered as follows:
The medication should be taken at the same time each day, with or without food. The tablets should be swallowed whole and not crushed, chewed, or broken. If a dose is missed, it should be taken on the same day as remembered but not taken twice in one day.
Belzutifan can cause several side effects, some of which may be serious. Common side effects include:
Serious side effects that require immediate medical attention include:
Patients should contact their doctor immediately if they experience any severe side effects. Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.
Before starting treatment with Belzutifan, patients should consider the following precautions:
Belzutifan provides a significant treatment option for adults with von Hippel-Lindau disease who need therapy for certain associated tumors. It is important to follow the prescribed administration guidelines, take necessary precautions, and consult with healthcare providers for personalized medical advice and treatment plans.
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