"What" Series

What is the difference between synthetic peptides and recombinant peptides?

19 April 2024
2 min read

Synthetic peptides and recombinant peptides are two different methods for the preparation of peptides, and they differ in their production processes, technical principles, application fields, as well as possible costs and scales.

·Production Process: 

Synthetic peptides: Typically refer to the preparation of peptides by chemical synthesis methods, which involves linking amino acids together to form a peptide chain with specific sequences using solid-phase synthesis (such as the Fmoc or Boc method) or liquid-phase synthesis. 

Recombinant peptides: Are prepared by biotechnological methods, such as expressing the genes of specific peptides in host cells (such as E. coli, yeast, or mammalian cells) using recombinant DNA technology, and then extracting and purifying the target peptides from these cells.

·Technical Principles: 

Synthetic peptides: Rely on chemical synthesis techniques, building the peptide chain by sequentially adding amino acids and forming peptide bonds. This method allows for precise control of the peptide sequence and modifications. 

Recombinant peptides: Depend on biological processes, synthesizing the peptide within a living organism as encoded by DNA sequences. This method can utilize the organism's natural mechanisms for folding and modifying peptides, sometimes resulting in a product that is closer to its natural form.

·Application Fields: 

Synthetic peptides: Widely used in research, drug development, diagnostic reagents, etc., particularly suitable for the preparation of short peptides and those difficult to produce by biotechnological methods. 

Recombinant peptides: Commonly used in the production of pharmaceuticals, such as insulin, growth hormone, interferons, as well as peptides for research and industrial applications.

·Cost and Scale: 

Synthetic peptides: For short peptides and peptides with specific modifications, the cost of synthesis may be low, but cost can significantly increase with the length of the peptide chain. 

Recombinant peptides: May have a cost advantage when produced at scale, particularly for peptides with large market demand.

Both methods have their own strengths and limitations, and the choice of method depends on various factors, including the characteristics of the target peptide, required scale, and cost-effectiveness. In practice, these two technologies are often combined to achieve optimal production efficiency and product quality.

图形用户界面, 文本, 应用程序, 聊天或短信

描述已自动生成

Eloxx Pharmaceuticals Offers Updates on ELX-02 and ZKN-013 Developments
Latest Hotspot
3 min read
Eloxx Pharmaceuticals Offers Updates on ELX-02 and ZKN-013 Developments
19 April 2024
Eloxx Pharmaceuticals, Inc. announced recent developments in their programs for ELX-02 and ZKN-013, highlighting the Orphan Drug Designation awarded to ELX-02.
Read →
Sacituzumab tirumotecan: A Quick Look at Its R&D Progress and Clinical Results from the 2024 AACR
Sacituzumab tirumotecan: A Quick Look at Its R&D Progress and Clinical Results from the 2024 AACR
19 April 2024
On April 5, 2024, the 2024 AACR present the updated data from a Phase 2 expansion cohort for patients (pts) with advanced NSCLC.
Read →
TOPAZ-1 Study: Doubling 3-Year Survival with Imfinzi-Chemo Combo in Advanced Biliary Cancer
Latest Hotspot
3 min read
TOPAZ-1 Study: Doubling 3-Year Survival with Imfinzi-Chemo Combo in Advanced Biliary Cancer
19 April 2024
In the TOPAZ-1 Phase III trial, the combination of Imfinzi and chemotherapy increased the three-year overall survival rate by twofold in patients with advanced biliary tract cancer.
Read →
What is the difference between toxoids and antitoxins?
"What" Series
2 min read
What is the difference between toxoids and antitoxins?
19 April 2024
Toxoids and antitoxins are distinct biological products used to prevent and treat toxin-related bacterial diseases, differing in origin, preparation, and function.
Read →
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.