Last update 01 Nov 2024

Hemorrhagic Fever With Renal Syndrome

Last update 01 Nov 2024

Basic Info

Synonyms

Epidemic Hemorrhagic Fever, Epidemic Hemorrhagic Fevers, Epidemic haemorrhagic fever

+ [93]

Introduction

An acute febrile disease occurring predominately in Asia. It is characterized by fever, prostration, vomiting, hemorrhagic phenonema, shock, and renal failure. It is caused by any one of several closely related species of the genus ORTHOHANTAVIRUS. The most severe form is caused by HANTAAN VIRUS whose natural host is the rodent Apodemus agrarius. Milder forms are caused by SEOUL VIRUS and transmitted by the rodents Rattus rattus and R. norvegicus, and the PUUMALA VIRUS with transmission by Clethrionomys galreolus.

Drugs associated with Hemorrhagic Fever With Renal Syndrome

Haemorrhagic Fever with Renal Syndrome Bivalent Vaccine(Vero Cell), Inactivated(Zhejiang Vacin Biomedicine Ltd)

Target-

Mechanism

Immunostimulants

Active Org.

Zhejiang Weixin Biological Pharmaceutical Co. Ltd.

Originator Org.

Zhejiang Weixin Biological Pharmaceutical Co. Ltd.

Active Indication

Hemorrhagic Fever With Renal Syndrome

Inactive Indication-

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date30 Sep 2007

pWRG/HTN-M(co)/pWRG/PUUV-M(United States Army Medical Research and Materiel Command)

Target

hantavirus M protein

Mechanism

hantavirus M protein inhibitors

Active Org.

Ichor Medical Systems, Inc. [+1]

Originator Org.

United States Army Medical Research and Materiel Command

Active Indication

Hemorrhagic Fevers, Viral

Inactive Indication

Hemorrhagic Fever With Renal Syndrome

Drug Highest PhasePhase 2

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Hantann virus vaccine(U.S. Army Medical Research and Development Command)

Target-

Mechanism

Immunostimulants

Active Org.-

Originator Org.

U S Army Medical Research & Development Command

Active Indication-

Inactive Indication

Hemorrhagic Fever With Renal Syndrome

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with Hemorrhagic Fever With Renal Syndrome

NCT06002529 / Not yet recruitingNot ApplicableIIT

Hemodiafiltration With Endogenous Reinfusion on Uremic Toxins Clearance of Maintenance Hemodialysis Patients

1.1Primary Objective To evaluate the clearance rate of uremic toxin β2-microglobulin (β2-MG), indoxyl sulfate and λ-free light chain (λFLC) by HFR.
1.2Secondary Objectives 1.1.1 To evaluate the clearance of low molecular weight uremic toxin urea (spKt/V, URR).
1.1.2 To evaluate the clearance of other middle molecules and macromolecular uremic toxins, including α1-microglobulin (α1-MG), κ-free light chain (κFLC), homocysteine (Hcy), interleukin-6 (IL-6), p-cresol, YKL-40, complement factor D (CFD), leptin, hippuric acid, trimethylamine oxide (TMAO), asymmetric dimethylarginine (ADMA), tumor necrosis factor-α (TNF- α), myoglobin, fibroblast growth factor 23 (FGF23) and intact parathyroid hormone (iPTH).
1.1.3 To evaluate the clearance of serum albumin, branched chain amino acids and vitamins A, C, E.
1.1.4 To evaluate the comfort of HFR treatment for MHD patients.

Start Date18 Aug 2023

Sponsor / Collaborator

Shanghai Renji Hospital

NCT04283513 / Not yet recruitingPhase 2IIT

Treatment Protocol for Adults With Hemorrhagic Fever With Renal Syndrome (HFRS) With Intravenous (IV) Ribavirin

Multisite protocol to provide IV Ribavirin treatment to patients with probable or suspected case of Hemorrhagic Fever with Renal Syndrome (HFRS)

Start Date31 Oct 2022

Sponsor / Collaborator

U S Army Medical Research & Development Command

ChiCTR2200064680 / SuspendedEarly Phase 1IIT

Efficacy of intravenous immunoglobulin (IVIG) in patients with severe epidemic hemorrhagic fever: a multicenter, prospective, randomized controlled study

Start Date14 Oct 2022

Sponsor / Collaborator-

100 Clinical Results associated with Hemorrhagic Fever With Renal Syndrome

100 Translational Medicine associated with Hemorrhagic Fever With Renal Syndrome

0 Patents (Medical) associated with Hemorrhagic Fever With Renal Syndrome

2,860

Literatures (Medical) associated with Hemorrhagic Fever With Renal Syndrome

01 Dec 2024·Virology

MicroRNA let-7a regulation of Hantaan virus replication by Targeting FAS Signaling Pathways

Article

Author: Chen, Xing-yuan ; Cheng, Qi ; Quan, Fang-Yi ; Xiang, Zhou-Fu ; Li, Ning ; Yang, Lan ; Xiong, Hai-rong ; Zhang, Wei-Hao ; Dai, Jian-wei ; Wang, Hui ; Xiong, Hai-Rong ; Ma, Jian-chun ; Hou, Wei ; Ma, Jian-Chun ; Chen, Ke-Han ; Xiang, Zhou-fu ; Zhang, Wei-hao ; Chen, Xing-Yuan ; Dai, Jian-Wei ; Liu, Yuan-yuan ; Liu, Yuan-Yuan ; Jiang, Ya-le ; Zhu, Shao-wei ; Zhu, Shao-Wei ; Quan, Fang-yi ; Chen, Ke-han

Hantaan virus (HTNV) infection in humans can cause hemorrhagic fever and renal syndrome (HFRS). Understanding host responses to HTNV infection is crucial for developing effective disease intervention strategies. Previous RNA-sequencing studies have investigated the role of microRNAs (miRNAs) in the post-transcriptional regulation of host genes in response to HTNV infection. In this study, we demonstrated that HTNV infection induces let-7a expression in human umbilical vein endothelial cells (HUVEC) and that HTNV G protein upregulates the expression of let-7a. miRNA let-7a mimics and inhibitors validated the predicted targets, including cell apoptosis genes (FAS, caspase-8, and caspase-3) and inflammatory factors (IL-6 and its related factors). Modulation of miRNA let-7a levels by miRNA mimics and inhibitors affected HTNV replication, indicating that HTNV modulates host miRNA expression to affect the outcome of the antiviral host response.

01 Dec 2024·Journal of Critical Care

Critical care management of hantavirus cardiopulmonary syndrome. A narrative review

Review

Author: Kraunik, David ; Pavez, Nicolas ; Cornu, Matias Germán ; Mondaca, Roberto ; Ulloa-Morrison, Rodrigo ; Fernandez, Paula ; Lopez, Rene ; Parra, Esteban ; Bravo, Sebastian ; Sanhueza, Claudia ; Kattan, Eduardo

Hantaviruses, members of the Bunyaviridae family, can cause two patterns of disease in humans, hantavirus hemorrhagic fever with renal syndrome (HFRS) and cardiopulmonary syndrome (HCPS), being the latter hegemonic on the American continent. Andesvirus is one of the strains that can cause HCPS and is endemic in Chile. Its transmission occurs through direct or indirect contact with infected rodents' urine, saliva, or feces and inhalation of aerosol particles containing the virus. HCPS rapidly evolves into acute but reversible multiorgan dysfunction. The hemodynamic pattern of HCPS is not identical to that of cardiogenic or septic shock, being characterized by hypovolemia, systolic dysfunction, and pulmonary edema secondary to increased permeability. Given the lack of specific effective therapies to treat this viral infection, the focus of treatment lies in the timely provision of intensive care, specifically hemodynamic and respiratory support, which often requires veno-arterial extracorporeal membrane oxygenation (VA-ECMO). This narrative review aims to provide insights into specific ICU management of HCPS based on the available evidence and gathered experience in Chile and South America including perspectives of pathophysiology, organ dysfunction kinetics, timely life support provision, safe patient transportation, and key challenges for the future.

01 Dec 2024·One Health

Asymmetric association between meteorological factors and human infections with hemorrhagic fever with renal syndrome: A 16-year ecological trend study in Shaanxi, China

Article

Author: Xue, Chenlu ; Zhang, Bingjie ; Xu, Chunjie ; Li, Yanyan ; Wang, Yongbin ; Li, Xinxiao

ObjectiveHemorrhagic fever with renal syndrome (HFRS) continues to pose a significant threat to global health. This study aimed to investigate both the long- and short-term asymmetric impacts of variations in meteorological variables on HFRS.MethodsThe reported monthly HFRS incidence data from Shaanxi between 2004 and 2019, along with corresponding meteorological data, were collected to conduct an ecological trend analysis. Subsequently, the autoregressive distributed lag (ARDL) and nonlinear ARDL (NARDL) models were used to examine the long- and short-term asymmetric effects of climate variables on HFRS incidence.ResultsOverall, a reduction in HFRS incidence was observed in Shaanxi from 2004 to 2019, with an average annual percentage change of -0.498 % (95 %CI -13.247 % to 12.602 %). HFRS incidence peaked in December and reached its lowest point in March each year. A 1 mm increase in aggregate precipitation (AP) was associated with a 4.3 % rise in HFRS incidence, while a 1 mm decrease contributed to a 3.7 % increase, indicating a long-term asymmetric impact (Wald long-term asymmetry test [WLT] = 9.072, P = 0.003). In the short term, a 1 % decrease in mean relative humidity (MRH) led to a 5.7 % decline in HFRS incidence (Wald short-term asymmetry test [WSR] = 5.978, P = 0.015). Additionally, changes in meteorological variables showed varied effects: ΔMWV(+) at a 1-month lag had a significant positive short-term effect on HFRS; ΔMRH(+) at a 3-month lag, ΔAP(+) at a 2-month lag, ΔAP(-) at a 1-month lag, ΔASH(+) at a 1-month lag, and ΔASH(-) at a 3-month lag all exhibited strong negative short-term impacts on HFRS incidence.ConclusionsWeather variability plays a significant role in influencing HFRS incidence, with both long- and short-term asymmetric and/or symmetric effects. Utilizing the NARDL model through a One Health lens offers promising opportunities for enhancing HFRS control measures.

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