Synonyms AF type amyloidosis, AMYLOIDOSIS, HEREDITARY, NEUROPATHIC, AMYLOIDOSIS, NEUROPATHIC + [158] |
Introduction Inherited disorders of the peripheral nervous system associated with the deposition of AMYLOID in nerve tissue. The different clinical types based on symptoms correspond to the presence of a variety of mutations in several different proteins including transthyretin (PREALBUMIN); APOLIPOPROTEIN A-I; and GELSOLIN. |
Target |
Mechanism TTR inhibitors |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. US |
First Approval Date21 Dec 2023 |
Target |
Mechanism TTR inhibitors |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication- |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. US |
First Approval Date13 Jun 2022 |
Target |
Mechanism TTR modulators |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. US |
First Approval Date03 May 2019 |
Start Date01 Dec 2024 |
Sponsor / Collaborator |
Start Date01 Oct 2024 |
Sponsor / Collaborator |
Start Date20 Sep 2024 |
Sponsor / Collaborator- |