Fasciitis, Plantar

MALVERN, Pa., Sept. 13, 2024 /PRNewswire/ -- Endo, Inc. ("Endo") (OTCQX: NDOI) announced today that data from a clinical study of collagenase clostridium histolyticum (CCH) in patients with plantar fibromatosis were presented during the American Orthopaedic Foot & Ankle Society's (AOFAS) annual scientific meeting, taking place through September 14, 2024. "Our clinical programs for plantar fibromatosis and plantar fasciitis are key elements of our future musculoskeletal pipeline indications, and we are pleased to share information with the medical community on these important data," said James P. Tursi, MD, Executive Vice President, Global Research & Development at Endo. The oral presentation covered data from the Phase 2 clinical study of CCH in patients with plantar fibromatosis. A Phase 2, Double-blind, Randomized, Placebo-Controlled Study to Assess Collagenase Clostridium Histolyticum vs Placebo in Patients With Plantar Fibromatosis Authors: Joseph Caporusso, DPM; Ira Gottlieb, DPM; Jason Levy, DPM, FACFAS; Saadiq El-Amin, MD; Sara E. Suttle, DPM, FACFAS; James Tursi, MD; Nigel Jones, PharmD; Luis Ortega, MD; Gongfu Zhou, PhD; C. James Anderson, DPM The results of the Phase 2 plantar fibromatosis study demonstrated a trend in CCH treatment effect over placebo for reducing pain associated with the condition as measured by the Foot Function Index Total Pain subscale score, as well as nominally significant improvements of CCH versus placebo in the investigator assessment of improvement of the condition, nodular hardness measured by durometer, and nodule consistency (firmness) by investigator palpation. In addition, the CCH safety profile was consistent with the known CCH safety profile from other clinical studies and indications. Most adverse events were local, rated as mild to moderate, and there were no reported treatment-related serious adverse events. CCH is not approved for use in treating patients with plantar fibromatosis. Endo is currently enrolling patients in the pivotal Phase 3 program. About Plantar Fibromatosis Plantar fibromatosis (PFI) or Ledderhose disease is a hyperproliferative fibrous tissue disorder resulting in the formation of nodules along the plantar fascia, the thick connective tissue that supports the arch of the foot, which is often painful. There is no cure for PFI. Symptom management options include custom insoles, topical treatments, over-the-counter pain and anti-inflammatory medications, radiation therapy and steroid injections, and ultimately, surgery may be required to remove the nodules. About Endo Endo is a diversified specialty pharmaceutical company boldly transforming insights into life-enhancing therapies. Our passionate team members collaborate to develop and deliver these essential medicines. Together, we are committed to helping everyone we serve live their best life. Learn more at or connect with us on LinkedIn. Cautionary Note Regarding Forward-Looking Statements This press release contains forward-looking statements including, but not limited to, the statements by Dr. Tursi and any statements relating to product efficacy, clinical trials or studies, patient enrollment, presentation of data, potential treatments or indications, therapeutic outcomes or treatment responses, safety or adverse events, and any statements that refer to expected, estimated or anticipated future results or that do not relate solely to historical facts. Statements including words such as "believes," "expects," "anticipates," "intends," "estimates," "plan," "will," "may," "look forward," "intends," "guidance," "future," "potential" or similar expressions are forward-looking statements. Because these statements reflect our current views, expectations and beliefs concerning future events, they involve risks and uncertainties, some of which we may not currently be able to predict. Although we believe that these forward-looking statements and other information are based upon reasonable assumptions and expectations, readers should not place undue reliance on these or any other forward-looking statements and information. Actual results may differ materially and adversely from current expectations based on a number of factors, including, among other things, unfavorable safety or efficacy data observed during clinical studies, preliminary data and trends that may not be predictive of future data or results, clinical study results that may not lead to regulatory approval by the FDA or other regulatory agencies, lower than expected clinical trial site activation or enrollment rates, uncertainties and timing of the regulatory approval process, unexpected litigation or other disputes, our ability to successfully implement and execute on our strategies and initiatives, and changes in competitive, market or regulatory conditions. Endo assumes no obligation to publicly update any forward-looking statements, whether as a result of new information, future developments or otherwise, except as may be required under applicable securities laws. Additional information concerning risk factors, including those referenced above, can be found in Endo's press releases and in its public filings with the U.S. Securities and Exchange Commission, including the discussion under the heading "Risk Factors" in Endo's most recent Form 10-Q and in Endo's final prospectus filed pursuant to Rule 424(b) under the Securities Act of 1933, as amended, in connection with Endo's Form S-1/A. SOURCE Endo, Inc. WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

TUESDAY, Jan. 30, 2024 -- For patients with chronic plantar fasciitis, extracorporeal shock wave therapy combined with local vibration (ESWT-LV) is effective compared with ESWT alone, according to a study recently published in the Journal of Rehabilitation Medicine . HyoJeong On and JongEun Yim, D.Sc., from the Graduate School of Sahmyook University in Seoul, South Korea, conducted a trial involving 34 patients (mean age, 37.5 years) with chronic plantar fasciitis who were randomly assigned to treatment with ESWT-LV or with ESWT alone. In each group, participants underwent two treatment sessions weekly for five weeks. The researchers found that in both groups, there were significant improvements in the thickness of the plantar fascia, numerical rating scale for pain, and Foot Function Index values. Significantly greater decreases were seen in the thickness of the plantar fascia and pain in the ESWT-LV versus the ESWT-alone group. Foot Function Index values did not differ significantly between the groups. "Based on these results, LV can be considered an effective adjunct to ESWT for plantar fasciitis," the authors write. "Further studies are necessary to determine the best parameters for LV combined with ESWT treatment in muscular skeletal disorders, in order to establish a treatment protocol." Abstract/Full Text (subscription or payment may be required) Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions. Posted January 2024 More news resources FDA Medwatch Drug Alerts Daily MedNews News for Health Professionals New Drug Approvals New Drug Applications Drug Shortages Clinical Trial Results Generic Drug Approvals Subscribe to our newsletter Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

BURLINGTON, ON, Nov. 6, 2023 /PRNewswire/ -- Dr. Ed Fillion, a celebrated Chiropractor, and Mike Cook, a Certified Athletic Therapist, Registered Massage Therapist and Doctor of Acupuncture, both from Total Health Link, are reaching out with actionable advice for those suffering from the physical strains of desk-bound lifestyles and other common musculoskeletal conditions. Effective At-Home Stretches for Desk Workers Continue Reading Doctor Ed Fillion Headshot Recognizing the impact of long hours spent at computers, Dr. Fillion and Mr. Cook recommend a series of simple yet effective stretches to alleviate postural strain: Pectoral Stretch: Stand in a doorway, place your arms on the door frame, and gently step through until you feel a stretch across your chest. Hold for 15-30 seconds. Psoas Stretch: In a lunge position, with one knee on the ground, tilt your pelvis forward to stretch the front of your hip on the kneeling side. Hold for 15-30 seconds. Hamstring Stretch: Seated on the ground, extend one leg out and reach toward your toes while keeping your back straight. Hold for 15-30 seconds. Glute Stretch: While seated, cross one ankle over the opposite knee and gently press down on the crossed knee. Hold for 15-30 seconds. To strengthen the muscles weakened by prolonged sitting, the duo advises: Rhomboid Strengthening: Perform exercises like seated rows, ensuring you're squeezing your shoulder blades together. Core Strengthening: Engage in exercises like planks and bridges to build core stability. Groundbreaking Pelvic Health Techniques to Try at Home For those dealing with incontinence, Mr. Cook suggests practicing pelvic floor exercises such as Kegels, which can be performed discreetly and without equipment, several times throughout the day. Home Remedies for Plantar Fasciitis Sufferers To combat the discomfort of plantar fasciitis, Dr. Fillion advises: Plantar Fascia Stretch: Roll your foot over a cold water bottle or a foam roller for a few minutes each day. Calf Stretch: Stand facing a wall with your hands on the wall, extend one leg back, and press the heel down until you feel a stretch in the calf. Managing Low Back Pain and Sciatica from Your Living Room For those experiencing low back pain with symptoms radiating down the leg, the experts recommend: Spinal Twists: Lying on your back, bring one knee across the body while keeping your shoulders flat on the ground. Pelvic Tilts: Lying on your back with knees bent, flatten your back against the floor by tightening your abdominal muscles and tilting your pelvis. About Total Health Link Total Health Link in Burlington, Ontario, is your destination for top-tier chiropractic and physiotherapy services. Led by Dr. Ed Fillion and Mike Cook, the clinic is dedicated to providing the community with the treatment, tools and knowledge necessary for maintaining optimal health and mobility. Contact Dr. Ed Fillion: [email protected] Phone: 905.333.4888 SOURCE Total Health Link