Periarthritis

Main research purpose: According to the relevant provisions of bioequivalence test, the flurbiprofen gel patch (trade name: Zepusi®, specification: 40mg) with the license holder Mikasa Seiyaku Co., Ltd was selected as the reference preparation, and the test preparation flurbiprofen gel patch (specification: 40mg) produced and provided by Jiangsu Wangao Pharmaceutical Co., Ltd. was subjected to human bioequivalence test under fasting external use conditions, to compare whether the absorption rate and degree of the drug in the test preparation were within the acceptable range with the reference preparation, and to evaluate the bioequivalence of the two preparations under external use conditions. Secondary research objectives: 1. Observe the safety of Chinese healthy subjects after external use of the test preparation flurbiprofen gel patch (specification: 40mg) and the reference preparation flurbiprofen gel patch (trade name: Zepusi®, specification: 40mg). 2. Evaluate the adhesion and external irritation of the test preparation flurbiprofen gel patch (specification: 40mg ) or the reference preparation flurbiprofen gel patch (trade name: Zepus®, specification: 40mg) applied externally to healthy volunteers during the trial.

Main purpose: Using the flurbiprofen gel patch (containing 40 mg of flurbiprofen per patch (area 13.6 cm × 10.0 cm, containing 12 g of paste), trade name Zepolas®) of the licensed manufacturer MIKASA SEIYAKU CO., LTD as the reference preparation, and the flurbiprofen gel patch (containing 12 g of paste per patch (area 13.6 cm × 10.0 cm), containing 40 mg of flurbiprofen) developed by Hunan Jinpu Pharmaceutical Technology Co., Ltd. as the test preparation, the bioequivalence of the two preparations under topical conditions in Chinese healthy subjects was evaluated. Secondary objectives: 1) To evaluate the safety of the test preparation and the reference preparation in Chinese healthy subjects; 2) To evaluate the adhesion of the test preparation and the reference preparation during the medication process in Chinese healthy subjects; 3) To evaluate the skin reactivity of the test preparation and the reference preparation in Chinese healthy subjects.