Synonyms CHORIOCARCINOMA, Choriocarcinoma, Choriocarcinoma (disorder) + [25] |
Introduction A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). It is characterized by the large amounts of CHORIONIC GONADOTROPIN produced. Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL). |
Target |
Mechanism Top II inhibitors |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication- |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. US |
First Approval Date17 May 1996 |
Target |
Mechanism DHFR inhibitors |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. JP |
First Approval Date01 Feb 1968 |
Target |
Mechanism DNA inhibitors |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. US |
First Approval Date10 Dec 1964 |
Start Date13 Nov 2023 |
Sponsor / Collaborator |
Start Date12 Apr 2023 |
Sponsor / Collaborator |
Start Date13 Mar 2023 |
Sponsor / Collaborator |