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Last update 08 May 2025

Epiglottitis

Last update 08 May 2025

Basic Info

Synonyms

EPIGLOTTITIS, Epiglottitides, Epiglottitis

+ [12]

Introduction

Inflammation of the EPIGLOTTIS.

Drugs associated with Epiglottitis

Hib conjugate vaccine(Chengdu Olymvax Biopharmaceuticals, Inc.)

Target-

Mechanism

Immunostimulants

Active Org.

Chengdu Olymvax Biopharmaceuticals, Inc.

Originator Org.

Chengdu Olymvax Biopharmaceuticals, Inc.

Active Indication

Haemophilus Infections

Inactive Indication

Arthritis [+4]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

China

First Approval Date18 May 2017

AC group meningococcal (combined) Haemophilus influenzae type b (combined) vaccine(Beijing Luzhu Biopharmaceutical Co., Ltd.)

Target-

Mechanism

Immunostimulants

Active Org.

Beijing Luzhu Biopharmaceutical Co., Ltd.

Originator Org.

Beijing Luzhu Biopharmaceutical Co., Ltd.

Active Indication

Meningococcal Infections

Inactive Indication

Epiglottitis [+4]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

China

First Approval Date02 Apr 2014

Haemophilus influenzae Type b conjugate Vaccine(Beijing Luzhu Biopharma)

Target-

Mechanism

Immunostimulants

Active Org.

Beijing Luzhu Biopharmaceutical Co., Ltd.

Originator Org.

Beijing Luzhu Biopharmaceutical Co., Ltd.

Active Indication

Haemophilus Infections [+5]

Inactive Indication-

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

China

First Approval Date31 Dec 2011

Clinical Trials associated with Epiglottitis

NCT06023550

/ RecruitingNot ApplicableIIT

Analysis of Complicated Infections in Pediatric and Adult Populations Treated by Otorhinolaryngologist

This observational study aims to learn more about complicated infections treated by otorhinolaryngologists. The main questions to answer are:
* What is the management of complicated sinonasal infections in Ljubljana, Slovenia,
* What is the management of complicated ear and temporal bone infections in Ljubljana, Slovenia,
* What is the management of complicated neck soft tissue infections in Ljubljana, Slovenia,
* What is the management of complicated laryngeal infections in Ljubljana, Slovenia
Participants will receive standard treatment according to the established evidence-based clinical practice.

Start Date01 Sep 2024

Sponsor / Collaborator

UMC Ljubljana

IRCT20210913052453N2

/ RecruitingPhase 3IIT

Efficacy of Jinhua Qinggan Granules (JHQG) for the Treatment of Upper Respiratory Infection: A Clinical Trial

Start Date22 Jun 2022

Sponsor / Collaborator-

CTR20210935

/ RecruitingPhase 3

合成b型流感嗜血杆菌结合疫苗III期临床研究

[Translation] Phase III clinical study of synthetic Haemophilus influenzae type b conjugate vaccine

评价长春海伯尔生物技术有限责任公司生产的合成b型流感嗜血杆菌结合疫苗在2月龄～5周岁健康婴幼儿中的免疫原性和安全性

[Translation]

To evaluate the immunogenicity and safety of the synthetic Haemophilus influenzae type b conjugate vaccine produced by Changchun Heber Biotechnology Co., Ltd. in healthy infants aged 2 months to 5 years

Start Date15 May 2021

Sponsor / Collaborator

Changchun Heber Biological Technology Co. Ltd.

100 Clinical Results associated with Epiglottitis

100 Translational Medicine associated with Epiglottitis

0 Patents (Medical) associated with Epiglottitis

1,456

Literatures (Medical) associated with Epiglottitis

08 Mar 2025·Cureus

Acute Respiratory Failure Due to Airway Obstruction in Forestier Syndrome: A Case Report

Article

Author: Ferreira, Nuno ; Magno, Marta ; Roriz, Carolina ; Araújo, Ana ; Santos, Cátia

Diffuse idiopathic skeletal hyperostosis (DISH) is characterized by calcification and ossification of ligaments, predominantly affecting the spine. Although often asymptomatic, it can cause dysphagia, dyspnea, and airway obstruction when anterior cervical osteophytes are involved. A 70-year-old male presented with severe dysphagia, respiratory distress, and weight loss. Magnetic resonance imaging (MRI) revealed prominent anterior cervical osteophytes (C2-C7), causing airway narrowing and esophageal compression, consistent with DISH. Acute respiratory failure with stridor required urgent intubation and mechanical ventilation. Due to surgical limitations at the initial hospital, the patient was transferred to a tertiary central facility for specialized care. This case highlights the diagnostic and therapeutic complexities of DISH-related airway obstruction. Multidisciplinary care proved critical, including corticosteroids, mechanical ventilation, and nutritional support. Acute respiratory decompensation may have been triggered by epiglottitis secondary to microaspiration. Early recognition and coordinated multidisciplinary management are essential for achieving optimal outcomes in severe DISH cases involving airway obstruction.

01 Mar 2025·Laryngo-Rhino-Otologie

Fall Epiglottitis

Article

Author: Schneider, Gerlind

01 Mar 2025·Indian Journal of Otolaryngology and Head & Neck Surgery

Laryngeal Abscess: A 34-Year Review

Article

Author: Cobo-Díaz, Ramón ; Corriols-Noval, Patricia ; Morales-Angulo, Carmelo ; Veiga-Alonso, Aida ; Salvatierra-Vicario, Belén

AbstractThis study aimed to investigate the frequency, clinical-epidemiological characteristics, and management of laryngeal abscesses in our hospital setting. We included all patients treated for primary laryngeal abscesses in the Otorhinolaryngology Department of a tertiary hospital over a 34-year period. Patients with abscesses believed to have originated from adjacent regions were excluded. Thirteen patients with laryngeal abscesses were identified, with epiglottitis being the most common etiology (61%). Three patients were immunosuppressed. Four patients required urgent tracheotomy, and one underwent cricothyrotomy due to upper airway obstruction. All cases were drained under general anesthesia via a transoral route. Five patients required admission to the intensive care unit, and two experienced severe complications. There were no fatalities. Laryngeal abscesses are rare, with epiglottitis being the predominant cause. These cases pose a high risk of upper airway obstruction, highlighting the importance of early diagnosis and prompt treatment by a multidisciplinary team to prevent complications.

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