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Last update 23 Jan 2025

Epiglottitis

Last update 23 Jan 2025

Basic Info

Synonyms

EPIGLOTTITIS, Epiglottitides, Epiglottitis

+ [12]

Introduction

Inflammation of the EPIGLOTTIS.

Drugs associated with Epiglottitis

Hib conjugate vaccine(Chengdu Olymvax Biopharmaceuticals, Inc.)

Target-

Mechanism

Immunostimulants

Active Org.

Chengdu Olymvax Biopharmaceuticals, Inc.

Originator Org.

Chengdu Olymvax Biopharmaceuticals, Inc.

Active Indication

Haemophilus Infections

Inactive Indication

Arthritis [+4]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date18 May 2017

AC group meningococcal (combined) Haemophilus influenzae type b (combined) vaccine(Beijing Luzhu Biopharmaceutical Co., Ltd.)

Target-

Mechanism

Immunostimulants

Active Org.

Beijing Luzhu Biopharmaceutical Co., Ltd.

Originator Org.

Beijing Luzhu Biopharmaceutical Co., Ltd.

Active Indication

Meningococcal Infections

Inactive Indication

Epiglottitis [+4]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date02 Apr 2014

Haemophilus influenzae Type b conjugate Vaccine(Beijing Luzhu Biopharma)

Target-

Mechanism

Immunostimulants

Active Org.

Beijing Luzhu Biopharmaceutical Co., Ltd.

Originator Org.

Beijing Luzhu Biopharmaceutical Co., Ltd.

Active Indication

Haemophilus Infections [+5]

Inactive Indication-

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date31 Dec 2011

Clinical Trials associated with Epiglottitis

NCT06023550

/ RecruitingNot ApplicableIIT

Analysis of Complicated Infections in Pediatric and Adult Populations Treated by Otorhinolaryngologist

This observational study aims to learn more about complicated infections treated by otorhinolaryngologists. The main questions to answer are:
* What is the management of complicated sinonasal infections in Ljubljana, Slovenia,
* What is the management of complicated ear and temporal bone infections in Ljubljana, Slovenia,
* What is the management of complicated neck soft tissue infections in Ljubljana, Slovenia,
* What is the management of complicated laryngeal infections in Ljubljana, Slovenia
Participants will receive standard treatment according to the established evidence-based clinical practice.

Start Date01 Sep 2024

Sponsor / Collaborator

UMC Ljubljana

IRCT20210913052453N2

/ RecruitingPhase 3IIT

Efficacy of Jinhua Qinggan Granules (JHQG) for the Treatment of Upper Respiratory Infection: A Clinical Trial

Start Date22 Jun 2022

Sponsor / Collaborator-

CTR20210935

/ RecruitingPhase 3

合成b型流感嗜血杆菌结合疫苗III期临床研究

[Translation] Phase III clinical study of synthetic Haemophilus influenzae type b conjugate vaccine

评价长春海伯尔生物技术有限责任公司生产的合成b型流感嗜血杆菌结合疫苗在2月龄～5周岁健康婴幼儿中的免疫原性和安全性

[Translation]

To evaluate the immunogenicity and safety of the synthetic Haemophilus influenzae type b conjugate vaccine produced by Changchun Heber Biotechnology Co., Ltd. in healthy infants aged 2 months to 5 years

Start Date15 May 2021

Sponsor / Collaborator

Changchun Heber Biological Technology Co. Ltd.

100 Clinical Results associated with Epiglottitis

100 Translational Medicine associated with Epiglottitis

0 Patents (Medical) associated with Epiglottitis

1,482

Literatures (Medical) associated with Epiglottitis

01 Jan 2025·European Archives of Oto-Rhino-Laryngology

Epidemiology, presentation, management and outcomes of patients with acute epiglottitis - A 10-year retrospective study based on a tertiary hospital in northern China

Article

Author: Fan, Zhitao ; Liu, Jingrui ; Shi, Sunan ; Qiao, Tong ; Wang, Yuetang ; Liu, Chaobing ; Zhang, Anqi

PURPOSEThis study aimed to explore the new clinical characteristics and trends of acute epiglottitis (AE) in northern China.METHODSA retrospective, observational study was conducted on patients diagnosed with AE between January 2014 and December 2023 at a single-center medical institution in northern China. The clinical profiles of patients with AE were investigated.RESULTSThis study encompassed 366 AE patients (M: F = 1.79:1). The average age of the patients was 47.31 ± 13.18 years, and 33.4% patients had comorbidities. Common initial symptoms: sore throat (93.17%), dysphagia (48.09%), fever (10.65%). Dyspnea reported in 14.48%. AE incidence rose annually over a decade, with mild seasonal variations. Laryngoscopy remains the primary means of confirming AE. Almost all patients received intravenous antibiotic therapy, and 98% of them were also treated with corticosteroids. Emergency airway intervention needed in 2.73% (cricothyroidotomy: 0.54%; tracheotomy: 2.19%). Among all patients, 353 (96.44%) had a good prognosis, 1 death (0.27%) from cardiopulmonary arrest during tracheotomy, 1 anoxic encephalopathy (0.27%) after tracheotomy in the emergency room due to intubation failure.CONCLUSIONThe incidence rate of AE is on the rise. Even if airway intervention is rarely required, clinicians must maintain a high degree of vigilance and conduct early identification of risk factors and emergencies that could progress severe cases into life-threatening. Furthermore, the development of safe and efficacious management strategies is crucial to prevent catastrophic complications and safeguard patient lives.

01 Jan 2025·Case Reports in Medicine

Refractory and Relapsing Laryngeal Edema Possibly Associated With Chronic Tonsillitis and Mycoplasma Infection, Requiring Reintubation and Tracheostomy

Article

Author: Ueki, Yukitaka ; Furuse, Yuki ; Ariyoshi, Koya ; Ohsato, Yasuo ; Nagae, Yuka ; Takahiro, Maeda ; Yoshida, Haruo ; Tsukamoto, Yutaka ; Umeda, Masataka ; Sugimoto, Takashi

Relapsing epiglottitis has rarely been reported, and its etiology is not well established. A 44‐year‐old previously healthy Japanese man presented with a quickly progressing choking sensation. He had been experiencing refractory and relapsing laryngeal edema and probably acute epiglottitis (three episodes within 2 weeks), with rash and elevated pancreatic amylase. The patient required immediate intubation. After the initial extubation, he required reintubation and a subsequent tracheostomy. Antibiotics, glucocorticoid, and antihistamines were administered, and he finally recovered with the tracheostomy’s closure. Potential causes of this patient’s relapsing epiglottitis are as follows: persistent right swollen tonsil; a positive result on a Mycoplasma pneumoniae antigen test and a particle agglutination (PA) test, implicating chronic tonsillitis; and/or Mycoplasma infection. This is the first case report of refractory and relapsing epiglottitis requiring reintubation possibly concurrent with chronic tonsillitis and Mycoplasma infection.

01 Dec 2024·Infectious Diseases Now

The emergence of streptococcal epiglottitis in adults amid Increasing iGAS cases

Letter

Author: Panagoulis, Evangelos ; Sideris, Giorgos ; Delides, Alexander ; Vlastarakos, Petros ; Papadimitriou, Nikolaos

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