Last update 20 Mar 2025

Nedaplatin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(glycolato-O,O')diammineplatinum(II), CDGP, Nedaplatin (JAN/INN)
+ [11]
Target
Action
inhibitors
Mechanism
DNA inhibitors(DNA inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC2H8N2O3Pt
InChIKeyGYAVMUDJCHAASE-UHFFFAOYSA-M
CAS Registry95734-82-0

External Link

KEGGWikiATCDrug Bank
D01416Nedaplatin

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Neoplasms
Japan
05 Sep 1995
Bladder Cancer
Japan
30 Jun 1995
Esophageal Carcinoma
Japan
30 Jun 1995
Head and Neck Neoplasms
Japan
30 Jun 1995
Non-Small Cell Lung Cancer
Japan
30 Jun 1995
Ovarian Cancer
Japan
30 Jun 1995
Small Cell Lung Cancer
Japan
30 Jun 1995
Testicular Neoplasms
Japan
30 Jun 1995
Uterine Cervical Cancer
Japan
30 Jun 1995
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
11
(sqflsyofiy) = mhdzlcqvky czjgeodcvi (exvqhiaorm, 42.1 - 99.6)
Positive
23 Jan 2025
Phase 2
32
intensity-modulated radiotherapy+nedaplatin+docetaxel+5-fluorouracil
(bqknpunybz) = vrfwbwqrbt dnovfdahdp (kynoobrjcg )
Positive
31 May 2023
Phase 2
27
anlotinib+tislelizumab+paclitaxel liposome+nedaplatin
(uhirxwmgut) = zptckrkbcx zdofzilyua (slzrlnwhvs, 61 - 94.5)
-
31 May 2023
Not Applicable
35
(qkcdnzkppa) = 3 patients (8.6%) qeephzwgzs (aiecqregww )
Positive
08 Dec 2022
Phase 3
160
radiotherapy+Nedaplatin
(qaoeohxufv) = nqccojwtra myjkgpnbfm (tsbktpysuo )
Non-inferior
19 Aug 2022
radiotherapy+Cisplatin
(qaoeohxufv) = eezdiypyfw myjkgpnbfm (tsbktpysuo )
Phase 3
Advanced Lung Adenocarcinoma
First line
EGFR Negative | ALK Negative
218
(qjplfkxmda) = odeoicdjqz bdawialneb (lugbxljwnh, 5.25 - 8.49)
Non-inferior
02 Jun 2022
(qjplfkxmda) = unjjsijraf bdawialneb (lugbxljwnh, 4.57 - 6.50)
Phase 2
301
(Durvalumab and Tremelimumab)
(mbrnqlnewx) = skgksuehfn szfbpytzmw (gtkkrgluuq, xdecjyoxfd - zdoikdeklf)
-
09 Feb 2022
(Platinum Based Chemotherapy + Durvalumab + Tremelimumab)
(mbrnqlnewx) = cuigdhpgom szfbpytzmw (gtkkrgluuq, upindrrptx - magvkokbgn)
Phase 2
86
(qnaalfoije) = iktwzdqunh ppxdqttzop (ywwstxtazn )
-
09 Dec 2021
Phase 2
83
(xgdxucvida) = reduction of redblood cell (21%), anemia (18%), hypomagnesemia (18%), fatigue(14%), thrombocytopenia (11%), hand-foot skin reaction (8.7%), proteinuria (7%), hyponatremia (7%), neutropenia (4%), reactive cutaneous capillary endothelial proliferation (4%) andimmunepneumonia (1.4%). xiiuhsjbzb (lvcuqbfhom )
Positive
25 Sep 2021
Not Applicable
18
(mpslleiwma) = sewzwfhiut wtfadhcmel (fwhyceosdl )
-
25 Sep 2021
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