Last update 21 Nov 2024

Larotrectinib Sulfate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Larotrectinib sulfate (JAN/USAN), larotrectinib, 拉罗替尼
+ [11]
Mechanism
TrkA antagonists(Nerve growth factor receptor Trk-A antagonists), TrkB inhibitors(Neurotrophic tyrosine kinase receptor type 2 inhibitors), TrkC inhibitors(Neurotrophic tyrosine kinase receptor type 3 inhibitors)
Inactive Indication-
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
US (26 Nov 2018),
RegulationConditional marketing approval (CN), Breakthrough Therapy (US), Orphan Drug (US), Priority Review (US), Accelerated Approval (US)
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Structure

Molecular FormulaC21H22F2N6O2
InChIKeyNYNZQNWKBKUAII-KBXCAEBGSA-N
CAS Registry1223403-58-4
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Locally Advanced Malignant Solid Neoplasm
AU
07 Sep 2020
NTRK fusion-positive solid tumors
EU
19 Sep 2019
NTRK fusion-positive solid tumors
IS
19 Sep 2019
NTRK fusion-positive solid tumors
LI
19 Sep 2019
NTRK fusion-positive solid tumors
NO
19 Sep 2019
Neoplasms
CA
10 Jul 2019
Solid tumor
US
26 Nov 2018
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Solid tumorPhase 2
DK
30 Sep 2015
Solid tumorPhase 2
IT
30 Sep 2015
Solid tumorPhase 2
SE
30 Sep 2015
Solid tumorPhase 2
BE
30 Sep 2015
Solid tumorPhase 2
BR
30 Sep 2015
Solid tumorPhase 2
KR
30 Sep 2015
Solid tumorPhase 2
AU
30 Sep 2015
Solid tumorPhase 2
RU
30 Sep 2015
Solid tumorPhase 2
SK
30 Sep 2015
Solid tumorPhase 2
IN
30 Sep 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
ESMO2024
ManualManual
Not Applicable
17
(eaujadurqj) = None fmzwedpkzw (nlmhnfdwrj )
Positive
16 Sep 2024
Not Applicable
302
(xlqzjqbxpv) = kpgrhrgmyy cztmsuqegn (pebuvdjvap, 59 - 70)
Positive
14 Sep 2024
Not Applicable
Neoplasms
First line
NTRK gene fusions
100
(epmtutmlvk) = bykghjekyq erhkfqkyji (cwqhrlehgb, 65 - 86)
Positive
14 Sep 2024
Larotrectinib
(adults)
(znuxbdnxkw) = qtzgmcuwoh bhulpvueji (ympjsqgwic, 54 - 79)
Not Applicable
32
(umhouuvhsd) = qddxkapvjf eapkijlmte (rlefkmjcoo )
Positive
10 Sep 2024
ASCO2024
ManualManual
Not Applicable
21
(opikqodevm) = jjwzzfqqeb mwycykciln (zvtyabuqet )
Positive
24 May 2024
Not Applicable
Lung Cancer
TRK fusion
32
(iitbmvdujg) = Treatment-related adverse events (TRAEs) were predominantly Grade 1/2. xfyozmjupb (qzzztyuorx )
Positive
24 May 2024
Not Applicable
Neoplasms
TRK fusion
164
(fykqkmhjfu) = idylwpdatl igbkgyljrb (crnqlcpzps )
Positive
24 May 2024
non-TRK inhibitor therapies
(fykqkmhjfu) = xmoojpzsqz igbkgyljrb (crnqlcpzps )
Not Applicable
31
(mpgalidzgo) = Treatment-related adverse events (TRAEs) were predominantly Grade 1/2. Grade 3/4 TRAEs were reported in 3 (10%) pts. There were no treatment discontinuations due to TRAEs. gcmjmlrril (zwpejoirbv )
Positive
24 May 2024
Not Applicable
Lung Cancer
NTRK gene fusion
27
(oszijffjxn) = Treatment-related adverse events were mostly Grade 1/2 dajkdtjwom (nzltswmmme )
Positive
22 Mar 2024
Not Applicable
First line
NTRK gene fusions
37
gauboipizk(pojpmypdwv) = psmjtkejti pkbgflwsdq (jwjguuiard, 87 - 100)
Positive
15 Mar 2024
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