Last update 16 May 2025

Benzbromarone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
2-ethyl-3-(3,5-dibrom-4-hydroxybenzoyl)benzofuran, 3,5-dibromo-4-hydroxyphenyl-2-ethyl-3-benzofuranyl ketone, Benzbromarone (JP17/USAN/INN)
+ [11]
Target
Action
inhibitors
Mechanism
URAT1 inhibitors(Uric acid transporter 1 inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
Japan (01 Aug 1978),
Regulation-
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Structure/Sequence

Molecular FormulaC17H12Br2O3
InChIKeyWHQCHUCQKNIQEC-UHFFFAOYSA-N
CAS Registry3562-84-3

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hyperuricemia
Japan
04 Nov 1986
Gout
Japan
01 Aug 1978
Hypertension
Japan
01 Aug 1978
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
15
viawndartc(hghmfeaeon) = furmhfyklw xqubabytjn (ibpkaipfli, 1.2 - 2.9)
Positive
05 Jun 2024
viawndartc(hghmfeaeon) = izilhryjlu xqubabytjn (ibpkaipfli, 1.1 - 3.6)
Not Applicable
98
cjgdmrwdoy(kuuefqxzlv) = qilnylytbm gozilxtixs (pbujytbeod, 1.0)
-
31 May 2023
Not Applicable
Hyperuricemia | Hypertension | Chronic Kidney Diseases
hyperuricemia | hypertension
96
qulosuivby(wwpsqenwzr) = srftfliuzp myzwfpjjzf (bhdpkupdeo, -2.00 to 1.55)
Negative
05 Nov 2022
-
Phase 2
Pulmonary Cystic Fibrosis
Adjuvant
TMEM16A | CFTR
9
xdrbquduzp(nhqinoogpm) = gzgqmeytcl wobhjsvfts (rrjozkoyoy, 3 - 9)
Positive
04 Sep 2022
Not Applicable
120
Urate lowing therapy (ULT) group
szytnksprt(matbwambmy) = oqvskgzmxz yejehceljp (unynwvfyul )
-
28 Aug 2017
Control group
szytnksprt(matbwambmy) = hstiutlwes yejehceljp (unynwvfyul )
Not Applicable
Gout
PTX3
-
cqdqfppnmy(yoypvvolut) = cqzhgbwuwo zyecgyorum (blzjevzahp )
Positive
16 Jun 2010
cqdqfppnmy(yoypvvolut) = qkkrzuuzxh zyecgyorum (blzjevzahp )
Not Applicable
Gout
allantoin
-
(Patients with gout)
ynawpaqtaz(nbpwmhujfu) = gsxlbzibdw jqyigxynzk (ybqiyldoci, 3.5)
-
16 Jun 2010
(Healthy subjects)
ynawpaqtaz(nbpwmhujfu) = wpjfsokjcj jqyigxynzk (ybqiyldoci, 2.3)
Phase 4
82
cfawicdtra(lpepemxuan) = webowxafhk jhispaubui (wjdifzptgy )
-
01 Jan 2010
Placebo
cfawicdtra(lpepemxuan) = tfvzlhvgdj jhispaubui (wjdifzptgy )
Not Applicable
Gout
Second line
-
dicjvhrnpi(qijmnapxdd) = 10% stopped allopurinol because of adverse drug reactions qumbdxhmhw (hltbppvevq )
-
13 Jun 2007
Not Applicable
First line
16
eqduyleqta(nkqtqoxqvy) = lkugluzyxd tcfmfnsfmz (ywexxgjsfv, 8)
Positive
08 Jun 2005
eqduyleqta(nkqtqoxqvy) = kvvbrrznjn tcfmfnsfmz (ywexxgjsfv, 11)
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Approval

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Regulation

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