Request Demo

Last update 20 Mar 2025

Oxymetazoline Hydrochloride

Last update 20 Mar 2025

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

2-(4-tert-butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazoline, 3-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethylphenol, 6-t-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol

+ [39]

Target

α1A-AR

Action

agonists

Mechanism

α1A-AR agonists(Alpha-1a adrenergic receptor agonists)

Therapeutic Areas

Cardiovascular DiseasesEye DiseasesOtorhinolaryngologic Diseases+ [3]

Active Indication

BlepharoptosisErythemaRosacea+ [3]

Inactive Indication

Fecal IncontinencePresbyopiaSpinal Cord Injuries+ [1]

Originator Organization

Schering-Plough Canada, Inc.

Active Organization

Santen SASSchering-Plough Canada, Inc.

Santen Pharmaceutical Co., Ltd.

+ [5]

Inactive Organization

Allergan UC

RDD Pharma Ltd.Bayer Healthcare LLC

+ [1]

Drug Highest PhaseApproved

First Approval Date

Canada (31 Dec 1964)

RegulationOrphan Drug (European Union)

Structure/Sequence

Molecular FormulaC16H25ClN2O

InChIKeyBEEDODBODQVSIM-UHFFFAOYSA-N

CAS Registry2315-02-8

Clinical Trials associated with Oxymetazoline Hydrochloride

CTIS2024-513356-15-00

/ RecruitingPhase 3

A Randomised, Double-Masked, Placebo-Controlled Phase 3 Study on the Efficacy and Safety of STN1013800 (Oxymetazoline HCl 0.1% Eye Drops) used twice daily (BID) in the Treatment of Acquired Blepharoptosis - 101380003SA

Start Date30 Dec 2024

Sponsor / Collaborator

Santen, Inc.

NCT06514612

/ RecruitingPhase 3

A Randomised, Double-Masked, Placebo-Controlled Phase 3 Study on the Efficacy and Safety of STN1013800 (Oxymetazoline HCl 0.1% Eye Drops) Used Twice Daily (BID) in the Treatment of Acquired Blepharoptosis

Start Date30 Dec 2024

Sponsor / Collaborator

Santen SAS

NCT06683651

/ RecruitingPhase 3

A Multicenter, Randomized, Double-Masked, Placebo-Controlled Parallel Group Phase III Study to Evaluate the Efficacy and Safety of STN1013800 Ophthalmic Solution in Chinese Patients With Acquired Blepharoptosis

This is a Phase III Study to evaluate the efficacy and safety of STN1013800 Ophthalmic Solution in Chinese Patients with Acquired Blepharoptosis.
At present, there are no medicines for the treatment of acquired blepharoptosis in China.
Therefore, to evaluate the efficacy and safety of 0.1% STN1013800 ophthalmic solution, Vehicle (Placebo) are designed.
For the screening period, 3-7 days were set to confirm the subjects and judge their qualification. Dosage and administration were based on prior clinical trial results approved at 0.1% once daily for 42 days treatment.

Start Date22 Oct 2024

Sponsor / Collaborator

Santen Pharmaceutical Co., Ltd.

100 Clinical Results associated with Oxymetazoline Hydrochloride

100 Translational Medicine associated with Oxymetazoline Hydrochloride

100 Patents (Medical) associated with Oxymetazoline Hydrochloride

1,645

Literatures (Medical) associated with Oxymetazoline Hydrochloride

01 Feb 2025·BRAZILIAN JOURNAL OF PHYSICS

Quantum Chemical Calculations, Spectroscopic Properties, Molecular Docking and ADMET Studies of 2-(4-Tert-Butyl-2,6-Dimethyl-3-Hydroxybenzyl)-2-Imidazoline

Author: Kalayci, Taner

Abstract: This study focuses on examining the mol. geometry, biol. activities, as well as the electronic and vibrational properties of 2-(4-tert-butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazoline (oxymetazoline).The investigation integrates quantum chem. calculations, mol. docking, and exptl. methods.The ground state geometry and electronic structure of oxymetazoline are optimized using the DFT/B3LYP/6-311 + + G(d,p) basis set.To predict the chem. reactivity of the title mol., MEPS, frontier orbital anal., and electronic reactivity descriptors were used.Charge transfer within the mol. was presented using HOMO and LUMO energies.The energies of intra and intermol. hydrogen bonds in mols., as well as their electronic properties, were examined using natural bond orbitals (NBOs).To determine the efficiency of the title chem., mol. docking tests were undertaken against α1A and α2A adrenergic receptors (α1A; PDB ID: 7YM8, 4MQT, and α2A; PDB ID: 3QAK, 7EJ8).According to the results, we found that the situation with the lowest binding score and therefore the best binding affinity is the OMZ-7YM8 interaction.The anal. of drug-likeness, physicochem. properties, and ADMET results indicates that the title mol. possesses a favorable pharmacokinetic profile and adheres to Lipinski′s Rule of Five, demonstrating efficient absorption and distribution.Consequently, the study supports the use of oxymetazoline as an inhibitor of α1A and α2A adrenergic receptors.

14 Jan 2025·JOURNAL OF CHROMATOGRAPHIC SCIENCE

Simultaneous Detection Method of 11 Respiratory Drug Substances Including Theobromine, Oxymetazoline, etc. in Adulterated Dietary Supplements Using Liquid Chromatography–Electrospray Ionization–Tandem Mass Spectrometry and Liquid Chromatography–Quadrupole Time-of-Flight Mass Spectrometry Analysis

Article

Author: Kim, Hyungil ; Shin, Hyunil ; Choi, Hwan Seong ; Kim, Mi Jin ; Lee, Ji Hyun ; Kim, Nam Sook

Abstract:

Recently, the demand for respiratory disease-related products has surged due to the influence of coronavirus disease 2019, prompting warnings about illegal dietary supplements containing unauthorized substances. Additionally, adulterated dietary supplements are continuously detected in open markets, posing significant public health safety problem. In this study, we developed and validated an analytical method for 11 respiratory drug substances using liquid chromatography–electrospray ionization–tandem mass spectrometry (LC–ESI–MS/MS) and proposed optimal conditions for LC–quadrupole time-of-flight MS (LC–QTOF-MS) to determine the fragmentation patterns of each substance. This method underwent thorough validation considering specificity, linearity, limits of detection and quantification, accuracy, precision, matrix effect, stability, etc. All results met international guidelines. These validated methods were applied to 52 dietary supplements advertised for treating respiratory diseases and enhancing respiratory function, among which one sample was found to contain 313.7 mg/g of theobromine. This determination was made by comparing the product ion ratios with the standards and subsequent quantification. To re-confirm the detected substances, their fragmentation patterns were compared with those of the standards using LC–QTOF-MS. In conclusion, the mass-based information, coupled with the LC–ESI–MS/MS method development, can be successfully applied to rapidly identify 11 respiratory drug substances in illegal dietary supplements used for respiratory disease treatment. The developed simultaneous detection method contributes to public health and safety improvements.

02 Jan 2025·Orbit-The International Journal on Orbital Disorders-Oculoplastic and Lacrimal Surgery

Use of oxymetazoline hydrochloride ophthalmic solution, 0.1% for improved lid symmetry in Graves’ disease

Article

Author: Vrcek, Ivan M. ; Vogt, Ashtyn Z.

PURPOSE:

The purpose of this study is to evaluate the usage of oxymetazoline hydrochloride ophthalmic solution, 0.1% in the treatment of Graves' disease to improve lid symmetry.

METHODS:

Fourteen patients were identified with unilateral upper eyelid retraction, secondary to Graves' disease. A phenylephrine test was performed to evaluate whether treating the unaffected (non-retracted) side would result in improved symmetry using Hering's law. Patients were prescribed oxymetazoline hydrochloride ophthalmic solution, 0.1% to instill into the unaffected eye. Marginal reflex distance 1 (MRD1) measurements were taken pre- and post-treatment and patient satisfaction surveys were completed.

RESULTS:

The average pre-treatment MRD1 difference between the right eye (OD) and the left eye (OS) was 2.46 [range 1.50-4.00]. The average post-treatment MRD1 difference between OD and OS was 0.39 [range 0.00-1.00]. One hundred percent of patients were satisfied or very satisfied with the improvement in symmetry.

CONCLUSIONS:

Oxymetazoline hydrochloride ophthalmic solution, 0.1% is a potential method to improve symmetry in patients with Graves' disease and unilateral upper eyelid retraction via Hering's law, especially for non-surgical candidates or those who prefer non-surgical treatment. Our results indicate improved MRD1 differences between fellow eyes and patient satisfaction regarding the symmetry of the upper eyelids.

News (Medical) associated with Oxymetazoline Hydrochloride

21 Nov 2024

·www.businesswire.com

Nasal Sprays Help Alleviate Nasal Congestion

AMERICAN FORK, Utah--( BUSINESS WIRE )--Today, Nathan Jones, CEO of Xlear Inc., a consumer hygiene products company, released this statement regarding the FDA’s proposal to remove popular over-the-counter decongestants, which contain the drug phenylephrine, from the market: “With the FDA concluding that this common decongestant isn’t effective, as we enter cold and flu season, and as families prepare to celebrate the holidays, many Americans need a new answer for the discomfort of sinus congestion,” Jones noted. “For people looking for help, the U.S. Centers for Disease Control (CDC) Guidance, ‘Relief for Symptoms of Colds and Coughs’, ‘instructions’ say to ‘use saline nasal spray to relieve congestion.’ i Similarly, CDC’s ‘Sinus Infection Basics’ say ‘How to Feel Better’ ‘use a . . . saline nasal spray,’” ii he pointed out. “You experience congestion because there is an irritant or pathogen in your upper airway that your body is trying to trap and wash away—your runny nose is your body flushing it out. Saline-based nasal sprays can help speed up that flushing, reduce pathogen load, and make it more effective. It’s commonsense: The faster the bad stuff is gone, the faster you feel better,” Jones added. “For congestion caused by pathogens—like colds and flus—people can enhance that effect by using a nasal spray that contains xylitol. A series of studies show xylitol (a natural sugar) deactivates and/or blocks the adhesion of many types of viruses and bacteria, to your airway cells,” iii Jones continued. Adhesion is the process by which a pathogen attaches to your tissue to initiate infection. Using a nasal spray with xylitol helps block adhesion of these pathogens. For example, a Randomized Controlled (clinical) Trial published in 2022, determined that a saline-nasal spray containing xylitol and other ingredients reduced the rate of COVID-19 infections by 62 percent above placebo. iv “Using a basic saline would be comparable to rinsing your hands with water; using a nasal spray with xylitol, like Xlear , would be comparable to washing your hands with soap. Expect more from your nasal hygiene products. Make sure they have xylitol so you can better and faster clean out the bad stuff while alleviating the congestion,” Jones added. Xlear nasal spray is a saline-based nasal spray containing xylitol. Xlear 12 Hour Nasal Decongestant is a saline-based nasal spray containing xylitol and the decongestant Oxymetazoline HCL. For more information on Xlear please visit www.xlear.com . ____________________________ i https://www-cdc-gov.libproxy1.nus.edu.sg/antibiotic-use/media/pdfs/HCP-Relief-Colds-Cough-85by11-P.pdf ii https://www-cdc-gov.libproxy1.nus.edu.sg/sinus-infection/about/index.html iii For example: T Kontiokari, M Uhari, M Koskela, Antiadhesive effects of xylitol on otopathogenic bacteria., Journal of Antimicrobial Chemotherapy , Volume 41, Issue 5, May 1998, Pages 563–565, https://academic-oup-com.libproxy1.nus.edu.sg/jac/article-abstract/41/5/563/652694?redirectedFrom=fulltext - google_vignette ; Kontiokari, T., Uhari, M., & Koskela, M. (1998). Antiadhesive effects of xylitol on otopathogenic bacteria. The Journal of Antimicrobial Chemotherapy , 41 (5), 563–565, https://academic-oup-com.libproxy1.nus.edu.sg/jac/article-abstract/41/5/563/652694?redirectedFrom=fulltext&login=false ; Jung, Kie Hoon. (2021). Antiviral Efficacy Against Virus Infections in Human-Derived Tracheal/Bronchial Epithelial Cells. Utah State University, https://xlrtmp.com/wp-content/uploads/2023/05/Antiviral-efficacy_USU2021.pdf ; Vega, J. C., et al., (2020). Iota carrageenan and xylitol inhibit SARS-CoV-2 in Vero cell culture. BioRxiv , https://professionals.xlear.com/portfolio/anti-adherence-of-viruses/ ; Ruiz, V., Rodríguez-Cerrato, V., Huelves, L. et al. Adherence of Streptococcus pneumoniae to Polystyrene Plates and Epithelial Cells and the Antiadhesive Potential of Albumin and Xylitol. Pediatr Res 69, 23–27, https://www-nature-com.libproxy1.nus.edu.sg/articles/pr920116 - citeas . iv Damian Balmforth, et al., Evaluating the efficacy and safety of a novel prophylactic nasal spray in the prevention of SARS-CoV-2 infection: A multi-centre, double blind, placebo-controlled, randomised trial., Journal of Clinical Virology, 155; 2022, https://www-sciencedirect-com.libproxy1.nus.edu.sg/science/article/pii/S1386653222001809 .

29 Oct 2024

·www.businesswire.com

NovaBay Pharmaceuticals Board Determines Unsolicited Offer is Superior to Asset Purchase Agreement with PRN Physician Recommended Nutriceuticals, LLC

EMERYVILLE, Calif.--( BUSINESS WIRE )-- NovaBay ® Pharmaceuticals, Inc . (NYSE American: NBY) (“NovaBay” or the “Company”) announces that the Company’s board of directors has determined that an unsolicited and non-binding offer from Refresh Acquisitions BidCo LLC (“Refresh”) for an affiliate of Refresh to acquire the Company’s Avenova ® brand and related assets is a “Superior Proposal” to the Company’s asset purchase agreement with PRN Physician Recommended Nutriceuticals, LLC (“PRN”). Refresh’s unsolicited offer provides for terms that are substantially similar to the contemplated transaction with PRN, except that the Company would receive a purchase price of up to $11.5 million (compared with $9.5 million in the transaction with PRN), subject to a downside net working capital adjustment. Refresh’s unsolicited offer also includes Refresh providing a secured term loan to the Company in the principal amount of $2.0 million, which is expected to be repaid upon closing and deducted from the purchase price. The Company has notified PRN of the board of directors’ determination and that the Company intends to terminate its asset purchase agreement with PRN unless the Company receives a revised proposal from PRN by 11:59 p.m. Pacific time on November 4, 2024, such that the Company’s board of directors determines that Refresh’s unsolicited offer is no longer a Superior Proposal, in accordance with the process provided in the asset purchase agreement with PRN. “After careful consideration, our board of directors determined that the unsolicited offer by Refresh represents greater value for our stockholders while also placing Avenova in highly capable commercial hands,” said Justin Hall, NovaBay CEO. “Refresh is an affiliate company of RVL Pharmaceuticals, which is commercializing Upneeq ® (oxymetazoline hydrochloride ophthalmic solution), 0.1%, the first and only FDA-approved prescription eye drops for adults with low-lying eyelids, also known as acquired blepharoptosis or ptosis. Our Avenova products are highly complementary to this non-surgical solution that quickly lifts eyelids for more awake-looking eyes. Further, RVL Pharmaceuticals and NovaBay are aligned in our shared passion for commercializing products that improve patients’ lives.” The Company’s asset purchase agreement with PRN, in accordance with such agreement, remains in full force and effect, and the Company’s board of directors has not withdrawn or modified its recommendation regarding stockholders approving the pending transaction with PRN. The Company’s transaction with PRN remains subject to certain closing conditions, including receiving stockholder approval. Consistent with its fiduciary duties, the Company’s board of directors conducted a comprehensive evaluation of the Refresh unsolicited offer with assistance from independent financial and legal advisors, before making its determination. About NovaBay Pharmaceuticals, Inc. NovaBay's leading product Avenova ® Lid & Lash Cleansing Spray is often recommended by eyecare professionals for blepharitis and dry eye disease. Manufactured in the U.S., Avenova spray is formulated with NovaBay's patented, proprietary, stable and pure form of hypochlorous acid. All Avenova products are available directly to consumers through online distribution channels such as Amazon.com and Avenova.com . Forward-Looking Statements This release contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995. Forward-looking statements are predictions, projections and other statements about future events that are based on current expectations and assumptions and, as a result, are subject to risks and uncertainties. These forward-looking statements are based upon the Company and its management’s current expectations, assumptions, estimates, projections and beliefs. Such statements include, but are not limited to, statements regarding the contemplated transaction with PRN, the unsolicited offer by Refresh and related matters. These statements involve known and unknown risks, uncertainties and other factors that may cause actual results or achievements to be materially different and adverse from those expressed in, or implied by, these forward-looking statements. Other risks relating to NovaBay's business, including risks that could cause results to differ materially from those projected in the forward-looking statements in this press release, are detailed in the Company's latest Form 10-K, subsequent Forms 10-Q and/or Form 8-K filings with the Securities and Exchange Commission (the “SEC”) and the Special Meeting Proxy Statement (as defined below), especially under the heading "Risk Factors." The forward-looking statements in this release speak only as of this date, and the Company disclaims any intent or obligation to revise or update publicly any forward-looking statement except as required by law. Additional Information and Where to Find It In connection with the solicitation of proxies, on October 16, 2024, NovaBay filed a definitive proxy statement with the SEC with respect to the special meeting to be held in connection with the proposed asset sale to PRN and a potential voluntary liquidation and dissolution of the Company (the “Special Meeting Proxy Statement”). Promptly after filing the Special Meeting Proxy Statement with the SEC, NovaBay mailed the Special Meeting Proxy Statement and a proxy card to each stockholder entitled to vote at the special meeting to consider the contemplated asset sale to PRN and potential dissolution. STOCKHOLDERS ARE URGED TO READ THE PROXY STATEMENT (INCLUDING ANY AMENDMENTS OR SUPPLEMENTS THERETO) AND ANY OTHER RELEVANT DOCUMENTS THAT NOVABAY HAS FILED OR WILL FILE WITH THE SEC BECAUSE THEY WILL CONTAIN IMPORTANT INFORMATION. Stockholders may obtain, free of charge, the Special Meeting Proxy Statement, any amendments or supplements thereto, and any other relevant documents filed by NovaBay with the SEC in connection with the contemplated asset sale to PRN and potential dissolution at the SEC's website ( http://www.sec.gov ) or at the Company’s investor relations website https://novabay.com/investors/ ) or by writing to NovaBay Pharmaceuticals, Inc., Investor Relations, 2000 Powell Street, Suite 1150, Emeryville, CA 94608. The information provided on, or accessible through, our website is not part of this communication, and therefore is not incorporated herein by reference. Participants in the Solicitation NovaBay and its directors and executive officers may be deemed to be participants in the solicitation of proxies from NovaBay's stockholders in connection with the contemplated asset sale to PRN and the potential dissolution. A list of the names of the directors and executive officers of the Company and information regarding their interests in the contemplated asset sale to PRN and the potential dissolution, including their respective ownership of the Company’s common stock and other securities is contained in the Special Meeting Proxy Statement. In addition, information about the Company’s directors and executive officers and their ownership in the Company is set forth in the Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2023 and filed with the SEC on March 26, 2024, as amended on March 29, 2024 and as modified or supplemented by any Form 3 or Form 4 filed with the SEC since the date of such filing. Socialize and Stay Informed on NovaBay ’ s Progress Like us on Facebook Follow us on X Connect with NovaBay on LinkedIn Visit NovaBay’s Website Avenova Purchasing Information For NovaBay Avenova purchasing information: Please call 800-890-0329 or email sales@avenova.com Avenova.com

Acquisition

27 Nov 2023

·www.globenewswire.com

RVL Completes Financial Restructuring

Athyrium Provides Capital to Support Long-Term Growth and Exchanges Outstanding Debt into Equity of Certain Reorganized Entities RVL Pharmaceuticals plc Ordinary Shares Expected to be Cancelled in 2024 BRIDGEWATER, N.J., Nov. 27, 2023 (GLOBE NEWSWIRE) -- RVL Pharmaceuticals, Inc. (“RVL” or the “Company”), a specialty pharmaceutical company focused on the commercialization of UPNEEQ® (oxymetazoline hydrochloride ophthalmic solution), 0.1%, for the treatment of acquired blepharoptosis, or droopy eyelids, in adults, today announced that it and its wholly-owned U.S. operating subsidiary RVL Pharmacy, LLC (collectively, the “RVL Subsidiaries”), successfully emerged from their Chapter 11 cases on November 22, 2023 following the confirmation by the United States Bankruptcy Court for the District of Delaware of their Plan of Reorganization (“Plan”) on November 20, 2023. RevitaLid Pharmaceutical Corp., previously the direct parent company of RVL Pharmaceuticals, Inc, concurrently emerged from its Chapter 11 case, though will be wound down under the Plan. “Upon emergence, the RVL Subsidiaries are well-positioned to invest in UPNEEQ, drive their strategic initiatives, and continue to deliver high-quality, innovative ocular and aesthetic solutions for patients and healthcare partners,” said Brian Markison, Chief Executive Officer of the Company. The Plan was unanimously supported by the RVL Subsidiaries’ sole secured lender (funds managed by Athyrium Capital Management, LP (“Athyrium”)) and other key stakeholders. The Company will continue to operate and be supported as a privately held company under the ownership of Athyrium. It is expected the wind-down of the Company’s former public parent company, RVL Pharmaceuticals plc, and its subsidiaries other than the RVL Subsidiaries will promptly commence, and RVL Pharmaceuticals plc’s public equity is expected to be cancelled upon completion of its wind-down during 2024, resulting in no recovery to public shareholders. About the Company RVL Pharmaceuticals, Inc. is a specialty pharmaceutical company focused on the commercialization of UPNEEQ® (oxymetazoline hydrochloride ophthalmic solution), 0.1%, for the treatment of acquired blepharoptosis, or low-lying eyelid, in adults. UPNEEQ is the first non-surgical treatment option approved by the FDA for acquired blepharoptosis. For more information, please visit the Company’s website at www.rvlpharma.com. IMPORTANT SAFETY INFORMATION INDICATION UPNEEQ® (oxymetazoline hydrochloride ophthalmic solution), 0.1%, is indicated for the treatment of acquired blepharoptosis in adults. WARNINGS AND PRECAUTIONS Ptosis Association: Ptosis may be associated with neurologic or orbital diseases such as stroke, cerebral aneurysm, Horner syndrome, myasthenia gravis, external ophthalmoplegia, orbital infection, and orbital masses. Consider these conditions in the presence of ptosis with decreased levator muscle function and/or other neurologic signs.Cardiovascular Impact: Alpha-adrenergic agonists as a class may impact blood pressure. Advise UPNEEQ patients with cardiovascular disease, orthostatic hypotension, and/or uncontrolled hypertension or hypotension to seek medical care if their condition worsens.Use with Caution: Use UPNEEQ with caution in patients with cerebral or coronary insufficiency or Sjögren’s syndrome. Advise patients to seek medical care if signs and symptoms of potentiation of vascular insufficiency develop.Glaucoma Risk: UPNEEQ may increase the risk of angle closure glaucoma in patients with untreated narrow-angle glaucoma. Advise patients to seek immediate medical care if signs and symptoms of acute narrow-angle glaucoma develop.Container Safety: Patients should not touch the tip of the single patient-use container to their eye or to any surface, in order to avoid eye injury or contamination of the solution. ADVERSE REACTIONS Adverse reactions that occurred in 1-5% of subjects treated with UPNEEQ include punctate keratitis, conjunctival hyperemia, dry eye, blurred vision, instillation site pain, eye irritation, and headache. DRUG INTERACTIONS Blood Pressure: Alpha-adrenergic agonists, as a class, may impact blood pressure. Exercise caution when using drugs such as beta-blockers, anti-hypertensives, and/or cardiac glycosides.Metabolism: Caution is advised in patients taking monoamine oxidase inhibitors, which can affect the metabolism and uptake of circulating amines. For inquiries, please contact: Brian Markisonbrianmarkison@rvlpharma.com

100 Deals associated with Oxymetazoline Hydrochloride

External Link

KEGG	Wiki	ATC	Drug Bank
D01022	Oxymetazoline Hydrochloride	R01AA05 S01GA04 R01AB07	DB00935

R&D Status

Approved

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Blepharoptosis	United States	RVL Pharmaceuticals, Inc.	08 Jul 2020
Erythema	United States	Mayne Pharma Ltd.	18 Jan 2017
Hyperemia	Japan	Sato Pharmaceutical Co., Ltd.	01 Aug 2007
Nasal Obstruction	China	Changzhou Yabang Pharmaceutical Co., Ltd.	01 Jan 1992
Rosacea	United States	Bayer Healthcare LLC	30 May 1986

Developing

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Blepharophimosis	Phase 3	Czechia	Santen SAS	30 Dec 2024
Blepharophimosis	Phase 3	France	Santen SAS	30 Dec 2024
Blepharophimosis	Phase 3	Germany	Santen SAS	30 Dec 2024
Blepharophimosis	Phase 3	Hungary	Santen SAS	30 Dec 2024
Blepharophimosis	Phase 3	Italy	Santen SAS	30 Dec 2024
Blepharophimosis	Phase 3	Netherlands	Santen SAS	30 Dec 2024
Blepharophimosis	Phase 3	Poland	Santen SAS	30 Dec 2024
Blepharophimosis	Phase 3	Spain	Santen SAS	30 Dec 2024
Blepharophimosis	Phase 3	United Kingdom	Santen SAS	30 Dec 2024
Fecal Incontinence	Phase 2	Hungary	RDD Pharma Ltd.	01 Nov 2014

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT05715346 (CTgov)	Phase 1/2	Blepharoptosis	33	LEV102 2.0% (LEV102 Topical Gel, 2.0%)	khnreyllrl = jvtvdafazd pbfadxdyur (epxbuifutj, mcvcglcitu - orxajlzmgi) View more	-	13 Nov 2024
				LEV102 1.0% (LEV102 Topical Gel, 1.0%)	khnreyllrl = dccnmydygu pbfadxdyur (epxbuifutj, uydfwqxxmt - oukfpxnina) View more
NCT04831047 (CTgov)	Phase 4	Eye Redness \| Conjunctivitis \| Blepharoptosis	114	Oxymetazoline hydrochloride 0.1% ophthalmic solution (Upneeq Group)	gzxivskcha(adltszjxuc) = arogdxwije blklqmofzr (eopkmwjcul, 1.1) View more	-	24 Apr 2023
				Placebo (Control Group)	gzxivskcha(adltszjxuc) = septegajea blklqmofzr (eopkmwjcul, 0.8) View more
AAD2023	Not Applicable	Acne Scar	30	OxH 0.05% solution	qhyhfwidel(jmdijxyzsa) = kaxvuvkcgc ojfjneujzx (gnsoyjngfb )	Positive	17 Mar 2023
				Placebo	qhyhfwidel(jmdijxyzsa) = pifuexxltk ojfjneujzx (gnsoyjngfb )
NCT04831047 (Pubmed \| J Plast Reconstr Aesthet Surg)	Not Applicable	Eye Redness \| Conjunctivitis \| Blepharoptosis	114	Topical oxymetazoline 0.1%	pwiyegasmf(hqkfiultuk) = ptqgjdssqj pkbbfdlgwt (klkgqvchom )	Positive	09 Feb 2023
NCT04153188 (CTgov)	Phase 4	-	34	The Vbeam® Prima System+Oxymetazoline HCL 1% Cream (Pulsed Dye Laser & Oxymetazoline HCL 1% Cream)	wvebeqicwj(riaxgnspcy) = ocjxealorv tbsjanaxlj (ujtzpqrfcs, 1.0) View more	-	18 Mar 2022
				Oxymetazoline HCL 1% Cream (Oxymetazoline HCL 1% Cream)	wvebeqicwj(riaxgnspcy) = ovuxyirlev tbsjanaxlj (ujtzpqrfcs, 1.0) View more
NCT01848041 (CTgov)	Phase 1/2	Blepharoptosis	46	RVL-1201 (RVL-1201 Once Daily)	wbdcfhswsu(fmzluplscd) = vhpcawrkuy gkcoxecorg (wqmgasokrq, 5.07) View more	-	22 Jul 2021
				RVL-1201 (RVL-1201 Twice Daily)	wbdcfhswsu(fmzluplscd) = qnfiyhnnek gkcoxecorg (wqmgasokrq, 4.64) View more
NCT03954444 (CTgov)	Phase 3	Rosacea	1,105	Oxymetazoline Hydrochloride (Oxymetazoline Hydrochloride Cream, 1%)	uangsqubhb: Mean Difference (Net) = 2.7 (90% CI, -2.6 to 8.0)	-	23 Jun 2021
				Rhofade Cream, 1% (RHOFADE Cream, 1%)
NCT03228914 (CTgov)	Phase 4	Hemorrhage \| Nasal Polyps	20	Oxymetazoline (Oxymetazoline)	hshonyrpcz(lgmlawqqov) = zurvvlfhrx hcbzewnxzj (uxegxninuw, 0.19) View more	-	13 Jan 2021
				Epinephrine (Epinephrine)	hshonyrpcz(lgmlawqqov) = wrzpcsryau hcbzewnxzj (uxegxninuw, 0.15) View more
NCT03352323 (CTgov)	Phase 3	Rosacea \| Erythema	50	Oxymetazoline	rwhptztdpv = tvsfoqjsgp rabsubdasr (qdsaoxofpu, wqgyyaehhd - rcunxwiatp) View more	-	05 Jan 2021
NCT02780115 (CTgov)	Phase 2	Presbyopia	151	AGN-190584 Vehicle	lbbcplwobw(hahhwjsszd) = hzutfzknxh jvxqchysbu (agtvtsnqei, 1.03) View more	-	22 Dec 2020

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis