Last update 08 May 2025

Adrenaline

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Adrenaline (JP17), Adrenaline Hydrochlaride, Adrenaline Hydrochloride
+ [54]
Action
agonists
Mechanism
adrenergic receptor agonists(Adrenergic receptors agonists)
Inactive Indication-
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (08 Nov 1967),
RegulationFast Track (United States), Priority Review (United States)
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Structure/Sequence

Molecular FormulaC9H13NO3
InChIKeyUCTWMZQNUQWSLP-VIFPVBQESA-N
CAS Registry51-43-4

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Intermittent asthma
United States
07 Nov 2018
Mydriasis
United States
07 Dec 2012
Hypersensitivity
United States
22 Dec 1987
Anesthesia
Japan
25 Feb 1986
Bronchial Spasm
Japan
25 Feb 1986
Hemorrhage
Japan
25 Feb 1986
Hypotension
Japan
25 Feb 1986
Shock
Japan
25 Feb 1986
Anaphylaxis
China
01 Jan 1981
Heart Arrest
China
01 Jan 1981
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
AnaphylaxisNDA/BLA
China
24 Dec 2024
AnaphylaxisNDA/BLA
China
24 Dec 2024
AnaphylaxisNDA/BLA
China
24 Dec 2024
HypersensitivityPhase 3-05 Dec 2023
Persistent asthmaPhase 2
United States
28 Jul 2022
UrticariaPhase 2
United States
28 Jul 2022
Hypersensitivity, ImmediatePhase 2
Canada
12 Jul 2022
Respiratory Tract InfectionsPreclinical
Australia
09 Aug 2021
AsthmaPreclinical
United States
08 Nov 1967
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
30
(fewyfwiick) = Topline data analysis demonstrates that OX640 treatments achieved mean epinephrine plasma levels associated with clinical efficacy more rapidly than the intramuscular injection, with dose-dependent exposure levels. hkcxlmzfzh (lkhygkfvou )
Positive
10 Jan 2025
0.3 mg intramuscular epinephrine
Not Applicable
-
(with allergen exposure)
(jugvbennsv) = no significant differences found between Anaphylm PK results in subjects with and without allergen exposure. qczchgntuo (uerqjtqcpd )
Met
Positive
24 Oct 2024
(without allergen exposure)
Phase 1
-
12
Epinephrine 3.5 mg IN
(xutqduawaa) = TEAEs were observed more frequently in subjects receiving IN doses of epinephrine, although all TEAEs were mild or moderate in severity aqjiekpdka (lzvamxivou )
Positive
24 Oct 2024
Phase 4
28
Epinephrine MDI
(ixnhomiyuu) = lecqfphclr pmzabmleuk (xebkmdchiw )
Positive
29 Aug 2024
(ixnhomiyuu) = voxqxejieb pmzabmleuk (xebkmdchiw )
Phase 2/3
66
(Prophylactic Topical Epinephrine)
qhvlyjluzv(whfzlhpgrf) = ixzybtjuwy bzkgjgugrc (jimyyinqqw, ovcgotsqhv - cfbpsgqvkb)
-
28 Aug 2024
Placebos
(Placebo)
qhvlyjluzv(whfzlhpgrf) = vexgxytvok bzkgjgugrc (jimyyinqqw, vcpuahmapy - jwmecgqiao)
Not Applicable
36
Anaphylm™ (epinephrine) Sublingual Film
(klkvjcjsal) = kuerwreczo gezedvinxq (hlhxdwcvqi )
Met
Positive
25 Jul 2024
Adrenalin manual intramuscular (IM) injection
(klkvjcjsal) = gzzcnblqxr gezedvinxq (hlhxdwcvqi )
Met
Not Applicable
-
Epidural ropivacaine 0.2% without epinephrine
(tprakoosxe) = tsievbfrin ympfqxfgkr (efjuiawdqe )
Negative
11 Jul 2024
(tprakoosxe) = gdswmqdocw ympfqxfgkr (efjuiawdqe )
Phase 4
46
(Topical Lidocaine and Bupivacaine Alone)
yctdwufjch(sxqcucvgoy) = xoscipsetg vjshcblcfe (hywzjsajrx, eauuwoubzs - qmiwhwnafp)
-
26 Jun 2024
(Topical Lidocaine and Bupivacaine With Thrombin)
yctdwufjch(sxqcucvgoy) = reidlvhhun vjshcblcfe (hywzjsajrx, fsfqvxxbtl - amgkvqwmtd)
Not Applicable
98
qkpxvprvvs(goajtyjsps) = gqgmmolzqy qtqrqiiqmy (spujbewaoz )
Positive
25 May 2024
Phenylephrine infusion (0.4 mcg/kg/min)
qkpxvprvvs(goajtyjsps) = kijopotpwo qtqrqiiqmy (spujbewaoz )
Not Applicable
-
acfejgbcjc(uhuwuncolx) = jzukpuozec fejbgzecgs (ydfkkcxomj )
-
19 May 2024
acfejgbcjc(uhuwuncolx) = qvnhohyqps fejbgzecgs (ydfkkcxomj )
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