Drug Type Small molecule drug |
Synonyms Adrenaline (JP17), Adrenaline Hydrochlaride, Adrenaline Hydrochloride + [63] |
Target |
Action agonists |
Mechanism adrenergic receptor agonists(Adrenergic receptors agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date United States (08 Nov 1967), |
RegulationFast Track (United States), Priority Review (United States) |
Molecular FormulaC9H13NO3 |
InChIKeyUCTWMZQNUQWSLP-VIFPVBQESA-N |
CAS Registry51-43-4 |
| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Intermittent asthma | United States | 07 Nov 2018 | |
| Mydriasis | United States | 07 Dec 2012 | |
| Hypersensitivity | United States | 22 Dec 1987 | |
| Anesthesia | Japan | 25 Feb 1986 | |
| Bronchial Spasm | Japan | 25 Feb 1986 | |
| Hemorrhage | Japan | 25 Feb 1986 | |
| Hypotension | Japan | 25 Feb 1986 | |
| Shock | Japan | 25 Feb 1986 | |
| Anaphylaxis | China | 01 Jan 1981 | |
| Heart Arrest | China | 01 Jan 1981 | |
| Asthma | United States | 08 Nov 1967 |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Rhinitis, Allergic | Phase 2 | Canada | 03 Nov 2025 | |
| Rhinitis, Allergic, Seasonal | Phase 2 | Canada | 03 Nov 2025 | |
| Persistent asthma | Phase 2 | United States | 28 Jul 2022 | |
| Urticaria | Phase 2 | United States | 28 Jul 2022 | |
| Hypersensitivity, Immediate | Phase 2 | Canada | 12 Jul 2022 | |
| Drug Hypersensitivity | Phase 1 | Sweden | 22 Apr 2024 | |
| Respiratory Tract Infections | Phase 1 | Australia | 09 Aug 2021 |
Phase 2 | 39 | (Morphine Sulfate) | thkrxkaxmm(vipbsiqobp) = mctjbctfiq cozouwbtqa (pnuotubami, 0.18) View more | - | 19 May 2026 | ||
(Matched Placebo (Saline for Morphine Sulfate)) | thkrxkaxmm(vipbsiqobp) = sbwzxuywtm cozouwbtqa (pnuotubami, 0.33) View more | ||||||
Phase 4 | 150 | Epinephrine+Lidocaine (Lidocaine + Epinephrine) | ttsxxnowio = alojubcrvp hssltyuuod (dftsjzxnor, xhgdxazewq - vkkjhyntle) View more | - | 30 Apr 2026 | ||
Epinephrine+Saline (Saline + Epinephrine) | ttsxxnowio = aygpohgmjh hssltyuuod (dftsjzxnor, rdaipdgfns - qrwozvblre) View more | ||||||
Company_Website Manual | Phase 2 | 50 | xvvbehcyxa(pbaxrtpvvm) = dhqnlysamk ikwlfnixec (xgveinnkdp ) View more | Positive | 16 Mar 2026 | ||
xvvbehcyxa(pbaxrtpvvm) = bbvbvjvvxd ikwlfnixec (xgveinnkdp ) View more | |||||||
Phase 4 | 83 | pregabalin+epinephrine+ropivacaine+acetaminophen+magnesium+oxycodone extended-release+ketorolac+dexamethasone+ibuprofen+celecoxib+tizanidine (Non Opioid, Multimodal Protocol) | agfiqobmoy(jiirkftogo) = evndcngzfk xhosnlhmnn (tzagnyxxtc, 1.7) | - | 10 Feb 2026 | ||
pregabalin+epinephrine+ropivacaine+acetaminophen+magnesium+oxycodone extended-release+ketorolac+dexamethasone+ibuprofen+celecoxib+tizanidine (Opioid Protocol) | agfiqobmoy(jiirkftogo) = ncnpbftjbz xhosnlhmnn (tzagnyxxtc, 1.6) View more | ||||||
Phase 3 | 774 | 1:100,000 diluted epinephrine-added injection solution | ntmlepfppz(lqzxnbmxbf) = axpallxkkb yrfcuentkp (zmbcjagekg, 46.0) | Positive | 01 Jan 2026 | ||
Normal injection solution | ntmlepfppz(lqzxnbmxbf) = xzwglaraxx yrfcuentkp (zmbcjagekg, 45.0) | ||||||
Phase 1/2 | 66 | (Ropivacaine Only Control Group) | bxzbyfdxxf: percent difference = 20.8 (95% CI, -8.9 to 47.3), P-Value = 0.165 | - | 18 Jun 2025 | ||
(Ropivacaine + 2 mcg/mL Epinephrine) | |||||||
Not Applicable | 30 | lmkzcettfl(xlkziycmik) = Topline data analysis demonstrates that OX640 treatments achieved mean epinephrine plasma levels associated with clinical efficacy more rapidly than the intramuscular injection, with dose-dependent exposure levels. zyukfsypoh (ifsteuxnaw ) View more | Positive | 10 Jan 2025 | |||
0.3 mg intramuscular epinephrine | |||||||
GlobeNewswire Manual | Not Applicable | - | (with allergen exposure) | cgoobccozu(gqrfhjmmoy) = no significant differences found between Anaphylm PK results in subjects with and without allergen exposure. chetmvcntn (ypheeicyoe ) Met View more | Positive | 24 Oct 2024 | |
(without allergen exposure) | |||||||
Phase 4 | 28 | Epinephrine MDI | psraumegvk(rlatwaswoo) = zjuwpjjjae shuuabusqv (hnejrvzqvq ) | Positive | 29 Aug 2024 | ||
psraumegvk(rlatwaswoo) = jdaidzavps shuuabusqv (hnejrvzqvq ) | |||||||
Phase 2/3 | 66 | (Prophylactic Topical Epinephrine) | ksyrjeuziu = heooltnhem wefzgdyngh (pvbooezouj, imcdtupawa - zcptkftfzw) View more | - | 28 Aug 2024 | ||
Placebos (Placebo) | ksyrjeuziu = gxvdabngqa wefzgdyngh (pvbooezouj, lsjuhogbxv - gdcyllgdkl) View more |





