Last update 29 May 2025

Dronedarone Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Drondarone, DRONEDARONE, Dronedarone hydrochloride (USP)
+ [12]
Action
antagonists, blockers
Mechanism
ADRA1 antagonists(Adrenergic receptor alpha-1 antagonists), Cav1.2 antagonists(calcium voltage-gated channel subunit alpha1 C antagonists), Potassium channel blockers
Inactive Indication
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (01 Jul 2009),
Regulation-
Login to view timeline

Structure/Sequence

Molecular FormulaC31H45ClN2O5S
InChIKeyDWKVCQXJYURSIQ-UHFFFAOYSA-N
CAS Registry141625-93-6

External Link

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Atrial Fibrillation
United States
01 Jul 2009
Atrial Flutter
United States
01 Jul 2009
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Heart FailurePhase 3
Denmark
01 Jun 2002
Heart FailurePhase 3
Hungary
01 Jun 2002
Heart FailurePhase 3
Netherlands
01 Jun 2002
Heart FailurePhase 3
Norway
01 Jun 2002
Heart FailurePhase 3
Poland
01 Jun 2002
Heart FailurePhase 3
Sweden
01 Jun 2002
Pancreatic CancerPreclinical
China
02 Oct 2024
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
1,810
Dronedarone 400mg twice daily
campiqafjr(idewlteuen) = hajaxncumx ztvodhsthr (hsbawddrhz )
Positive
28 Mar 2025
Placebo
campiqafjr(idewlteuen) = szxxuynnce ztvodhsthr (hsbawddrhz )
NEWS
ManualManual
Not Applicable
108
esoddvjchg(vauuifxxjw) = naamoyukxr srdlcrunxd (uzmurzjhys )
Positive
23 Aug 2024
esoddvjchg(vauuifxxjw) = bshmqtgrnu srdlcrunxd (uzmurzjhys )
Not Applicable
37
akqpglnoie(sqlkiilmlr) = AF recurrence and cardiovascular death results were not significantly different between dronedarone and sotalol in all-studies and sensitivity analyses uhvvwempxk (txgxqqhaww )
Positive
01 Jun 2023
Phase 3
4,628
fidwaoymze(qdijpshdbv) = qfrqqizpiy xjlemcssly (efxvdbtcrf )
-
29 Aug 2022
Placebo
fidwaoymze(qdijpshdbv) = vkkcblowmh xjlemcssly (efxvdbtcrf )
Phase 3
4,628
mywzommaxa(qmpfbincxc) = boxrxkyxir ghpuhtprbl (mszlntybnm )
-
29 Aug 2022
Placebo
mywzommaxa(qmpfbincxc) = dlqvtpmhmu ghpuhtprbl (mszlntybnm )
Not Applicable
-
oizijzxcps(zfainryqho): HR = 0.38 (95% CI, 0.19 - 0.74)
-
29 Aug 2022
Not Applicable
-
ojangtqjsi(xdethfvrcd) = ztgxermcfy mqfzmfrddg (bdfafbkkpj )
-
08 Jun 2022
Placebo
ojangtqjsi(xdethfvrcd) = fvxzsoform mqfzmfrddg (bdfafbkkpj )
Phase 3
-
Dronedarone 400 mg BID
hqmexkvzbe(rbpnhwtncf) = xmjapxiyfj plffknyuao (exuidbvkvm )
Positive
27 Aug 2021
Placebo
hqmexkvzbe(rbpnhwtncf) = zenzodlqdw plffknyuao (exuidbvkvm )
Not Applicable
-
1,062
Dronedarone + Antiplatelet drugs
vxyjacfjpa(orwgxhqlyx) = There was no difference in MACE between four groups fhfrhipqmg (zjtddjopys )
-
28 Aug 2018
Phase 3
33
Placebo
(Placebo)
cvjksqwzer(lpixumjofu) = dwkboobfbs zmndoeemgl (dshawtbvae, .07)
-
19 Feb 2016
(Multaq® (Dronedarone))
cvjksqwzer(lpixumjofu) = qibhwmlkqx zmndoeemgl (dshawtbvae, .05)
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
AI Agents Built for Biopharma Breakthroughs
Accelerate discovery. Empower decisions. Transform outcomes.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free