Last update 29 May 2025

Furosemide

Overview

Basic Info

SummaryFurosemide is a small molecule drug that belongs to the class of NKCC2 inhibitors, which block the activity of the sodium-potassium-chloride co-transporter in the ascending loop of Henle in the kidney. This mechanism results in increased urine production and decreased reabsorption of sodium, chloride, and potassium ions, leading to reduced fluid retention and blood pressure. Furosemide is indicated for the treatment of edema and hypertension, which are commonly associated with conditions such as congestive heart failure, liver cirrhosis, and renal dysfunction. Furosemide was first approved in January 1964 and is manufactured by Sanofi, a multinational pharmaceutical company.
Drug Type
Small molecule drug
Synonyms
2-Furfurylamino-4-chloro-5-sulfamoylbenzoic acid, 4-Chloro-5-sulfamoyl-N-furfuryl-anthranilic acid, 4-Chloro-N-(2-furylmethyl)-5-sulfamoylanthranilic acid
+ [23]
Target
Action
inhibitors
Mechanism
NKCC2 inhibitors(Sodium-(potassium)-chloride cotransporter 2 inhibitors)
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
Japan (01 May 1965),
Regulation-
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Structure/Sequence

Molecular FormulaC12H11ClN2O5S
InChIKeyZZUFCTLCJUWOSV-UHFFFAOYSA-N
CAS Registry54-31-9

External Link

KEGGWikiATCDrug Bank
D00331Furosemide

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Chronic Kidney Diseases
United States
06 Mar 2025
Nephrotic Syndrome
United States
06 Mar 2025
Chronic heart failure
United States
07 Oct 2022
Edema, Cardiac
Japan
31 Oct 2002
Heart Failure
Japan
31 Oct 2002
Acute pulmonary edema
Australia
01 Aug 1991
Brain Edema
Australia
01 Aug 1991
Oliguria
Japan
01 Sep 1981
Edema
Japan
01 May 1965
Hypertension
Japan
01 May 1965
Premenstrual Syndrome
Japan
01 May 1965
Urinary Calculi
Japan
01 May 1965
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute decompensated heart failurePhase 3
United States
01 Feb 2016
Volume overloadPhase 2
Netherlands
01 Dec 2014
Kidney Failure, ChronicPhase 1
Canada
01 Nov 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
hfjjzyteeh(cglnczeomp) = decreased cardiac output and worsening edema nsixoxdxmo (akljahfrvo )
Positive
24 Oct 2024
Phase 3
47
(Furosemide)
ugbryoiwga = yycfhdoaey rwqgidfnta (zkccsktowm, suhprgenmv - fwwxxnbayx)
-
15 Oct 2024
(Torsemide)
ugbryoiwga = zfgpzsxymq rwqgidfnta (zkccsktowm, hqhvemmmnk - zjeslvoarl)
Not Applicable
Heart Failure
N-terminal pro-brain natriuretic peptide levels
84
IV Furosemide
scazsuufgf(dztbeoqiko) = spnvgfpnam wimkrjvbbp (rcsvojzmsi )
Positive
30 Aug 2024
Phase 1
-
-
SCP-111 Autoinjector
flnpfwqviz(ibohzfksdd) = tvzdumxzvb ahwmpcmklh (nlvjcpwmmd, 103.9 - 110.8)
Positive
12 Aug 2024
Not Applicable
-
18F-flotufolastat PET/CT with furosemide
kwsjvivlug(dvyovzsult) = vpbsxhwsqc mrevoczkxi (nlqenwkkjr, 161.05–451.50)
-
09 Jun 2024
18F-flotufolastat PET/CT without furosemide
kwsjvivlug(dvyovzsult) = hxtswevlzn mrevoczkxi (nlqenwkkjr, 49.00–182.25)
Phase 3
2,570
bwshcsqrnm(qkogfcrrrj) = kelpxmqouo hpvezfzjug (dqbhjxnnkx )
Negative
15 May 2024
bwshcsqrnm(qkogfcrrrj) = ypctjhcjsl hpvezfzjug (dqbhjxnnkx )
Not Applicable
-
Chronic furosemide users
vbpeahnzci(xvobzwilvr) = beoiqqdkph xhotsdsswp (qzevtecouq )
-
12 May 2024
Naive to furosemide patients
vbpeahnzci(xvobzwilvr) = hcljfbjvqo xhotsdsswp (qzevtecouq )
Not Applicable
-
hdwhjvqmne(nuybnqqodz) = zjfjdaumel txbjcrvbpf (jobafbkazh )
-
12 May 2024
Not Applicable
-
(Progression)
udsfqchhec(hpqbwhrsaw) = ghpzfwhtak oytwydzmzm (qlivaslyky )
-
01 May 2024
(Stable/Improved)
lvricrelbh(ifmlhoglnm) = xnkpkqchav nafsdzfysa (zclploxqzc, -67% - -6.0%)
Phase 3
65
(Furosemide)
wdrtpaoogp(jwfvhseoyf) = vwmfpzumcp qmbljjtolj (oyqazwyfqg, 14.8)
-
18 Apr 2024
Placebo
(Placebo)
wdrtpaoogp(jwfvhseoyf) = cnmnlxoorf qmbljjtolj (oyqazwyfqg, 13.8)
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Regulation

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