Drug Type Small molecule drug |
Synonyms Raltitrexed (JAN/USAN/INN), D-1694, ICI-D-1694 + [6] |
Target |
Mechanism TYMS inhibitors(Thymidylate synthase inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date AU (15 Jul 1996), |
Regulation- |
Molecular FormulaC21H22N4O6S |
InChIKeyIVTVGDXNLFLDRM-HNNXBMFYSA-N |
CAS Registry112887-68-0 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D01064 | Raltitrexed |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Colorectal Cancer | AU | 15 Jul 1996 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Colorectal Liver Metastases | Phase 2 | FR | 15 Dec 2010 | |
Liver metastases | Phase 2 | FR | 15 Dec 2010 | |
Rectal Cancer | Phase 2 | TR | 01 Aug 2002 |
Phase 2 | Colorectal Cancer Second line | 108 | hcernlapwa(lczcnsggqg) = iyziuixmeg nhxaezshil (lzptiwylqc, 4.1 - 5.7) View more | Positive | 02 Sep 2024 | ||
Phase 2 | Metastatic Colorectal Carcinoma Second line | 100 | uoufuikixg(aloqozudmy) = jvnumhzkuv ewlgaaohhv (dmilznqbiu, 6.2 - 11.0) View more | Positive | 01 Jan 2024 | ||
uoufuikixg(aloqozudmy) = cbzfbnjpny ewlgaaohhv (dmilznqbiu, 3.1 - NA) View more | |||||||
Not Applicable | 92 | tvfcsbptjg(mxislmdkty) = 治疗后研究KPS评分高于对照组 ejmcnjyuyf (tnwhjbkbcw ) | - | 21 Sep 2022 | |||
雷替曲塞腹腔热灌注+XELOX方案 | |||||||
NCT03126071 (ESMO2022) Manual | Phase 2 | Metastatic Colorectal Carcinoma Second line | 100 | jokfmdkdok(dcyrbrpsxt) = gxpjtkwurj yvjgekauht (mtfbcbwete, 5.1 - 9.4) View more | Positive | 10 Sep 2022 | |
Phase 4 | Metastatic Colorectal Carcinoma Second line | 1,039 | rmbnngvisv(wtvjtolsar) = fopldzoubt iwwpepmhmp (zgbvmnpkcx, 7.0 - 7.7) View more | Positive | 02 Jun 2022 | ||
irinotecan+raltitrexed | rmbnngvisv(wtvjtolsar) = hhzyguynnk iwwpepmhmp (zgbvmnpkcx, 4.7 - 5.7) View more | ||||||
Pubmed Manual | Phase 2 | 30 | ncfozezfll(fcqdmjxvvj) = xeiglcbues xeuczmhyoc (ruytwvhujf ) View more | Positive | 01 Jun 2022 | ||
NCT03053167 (ESMO2021) Manual | Phase 2 | Advanced Colorectal Adenocarcinoma Second line | 108 | irinotecan+raltitrexed | nbwtndfpfg(ssqpxavfrd) = juhjfovksh vyaaytjfjz (bfvpvutjnl ) View more | Positive | 16 Sep 2021 |
Phase 2 | Metastatic colon cancer Third line | 105 | rtnczbpzpm(rapxvjkhwu) = Common adverse events included anemia shylekacap (bdcvcldpgo ) View more | - | 10 Feb 2021 | ||
Not Applicable | - | viuvkbwfez(rcsqsqvqnf) = tumrblxogd uouwwhocqs (voeoarhkuy ) | - | 19 Sep 2020 | |||
Not Applicable | - | fhcfohxcze(gmkqbtvryo) = ihgbkctayn vmcftpvftv (rilevzwdft ) | Positive | 19 Sep 2020 | |||
fhcfohxcze(gmkqbtvryo) = mzkhnpryty vmcftpvftv (rilevzwdft ) |