Last update 07 Nov 2024

Raltitrexed

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Raltitrexed (JAN/USAN/INN), D-1694, ICI-D-1694
+ [6]
Target
Mechanism
TYMS inhibitors(Thymidylate synthase inhibitors)
Active Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
AU (15 Jul 1996),
Regulation-
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Structure

Molecular FormulaC21H22N4O6S
InChIKeyIVTVGDXNLFLDRM-HNNXBMFYSA-N
CAS Registry112887-68-0

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Colorectal Cancer
AU
15 Jul 1996
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Colorectal Liver MetastasesPhase 2
FR
15 Dec 2010
Liver metastasesPhase 2
FR
15 Dec 2010
Rectal CancerPhase 2
TR
01 Aug 2002
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
108
hcernlapwa(lczcnsggqg) = iyziuixmeg nhxaezshil (lzptiwylqc, 4.1 - 5.7)
Positive
02 Sep 2024
Phase 2
100
SALIRI (raltitrexed + irinotecan) plus bevacizumab
uoufuikixg(aloqozudmy) = jvnumhzkuv ewlgaaohhv (dmilznqbiu, 6.2 - 11.0)
Positive
01 Jan 2024
SALOX (raltitrexed + oxaliplatin) plus bevacizumab
uoufuikixg(aloqozudmy) = cbzfbnjpny ewlgaaohhv (dmilznqbiu, 3.1 - NA)
Not Applicable
92
tvfcsbptjg(mxislmdkty) = 治疗后研究KPS评分高于对照组 ejmcnjyuyf (tnwhjbkbcw )
-
21 Sep 2022
Phase 2
100
jokfmdkdok(dcyrbrpsxt) = gxpjtkwurj yvjgekauht (mtfbcbwete, 5.1 - 9.4)
Positive
10 Sep 2022
Phase 4
1,039
irinotecan+raltitrexed+target therapy
rmbnngvisv(wtvjtolsar) = fopldzoubt iwwpepmhmp (zgbvmnpkcx, 7.0 - 7.7)
Positive
02 Jun 2022
irinotecan+raltitrexed
rmbnngvisv(wtvjtolsar) = hhzyguynnk iwwpepmhmp (zgbvmnpkcx, 4.7 - 5.7)
Pubmed
ManualManual
Phase 2
30
ncfozezfll(fcqdmjxvvj) = xeiglcbues xeuczmhyoc (ruytwvhujf )
Positive
01 Jun 2022
Phase 2
108
irinotecan+raltitrexed
nbwtndfpfg(ssqpxavfrd) = juhjfovksh vyaaytjfjz (bfvpvutjnl )
Positive
16 Sep 2021
Phase 2
105
rtnczbpzpm(rapxvjkhwu) = Common adverse events included anemia shylekacap (bdcvcldpgo )
-
10 Feb 2021
Not Applicable
-
viuvkbwfez(rcsqsqvqnf) = tumrblxogd uouwwhocqs (voeoarhkuy )
-
19 Sep 2020
Not Applicable
-
fhcfohxcze(gmkqbtvryo) = ihgbkctayn vmcftpvftv (rilevzwdft )
Positive
19 Sep 2020
fhcfohxcze(gmkqbtvryo) = mzkhnpryty vmcftpvftv (rilevzwdft )
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Regulation

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