Drug Type Small molecule drug |
Synonyms BEIZRAY, DEP® docetaxel, Docetaxel Hydrate + [57] |
Target |
Mechanism PSMA inhibitors(Prostate-specific membrane antigen inhibitors) |
Therapeutic Areas |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date EU (27 Nov 1995), |
RegulationAccelerated Approval (US), Priority Review (CN) |
Molecular FormulaC43H55NO15 |
InChIKeyYWKYKORYUFJSCV-XKIQGVRMSA-N |
CAS Registry148408-66-6 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Gastroesophageal junction adenocarcinoma | EU | 22 May 2012 | |
Gastroesophageal junction adenocarcinoma | EU | 22 May 2012 | |
Gastroesophageal junction adenocarcinoma | IS | 22 May 2012 | |
Gastroesophageal junction adenocarcinoma | IS | 22 May 2012 | |
Gastroesophageal junction adenocarcinoma | LI | 22 May 2012 | |
Gastroesophageal junction adenocarcinoma | LI | 22 May 2012 | |
Gastroesophageal junction adenocarcinoma | NO | 22 May 2012 | |
Gastroesophageal junction adenocarcinoma | NO | 22 May 2012 | |
Locally Advanced Head and Neck Squamous Cell Carcinoma | EU | 22 May 2012 | |
Locally Advanced Head and Neck Squamous Cell Carcinoma | EU | 22 May 2012 | |
Locally Advanced Head and Neck Squamous Cell Carcinoma | IS | 22 May 2012 | |
Locally Advanced Head and Neck Squamous Cell Carcinoma | IS | 22 May 2012 | |
Locally Advanced Head and Neck Squamous Cell Carcinoma | LI | 22 May 2012 | |
Locally Advanced Head and Neck Squamous Cell Carcinoma | LI | 22 May 2012 | |
Locally Advanced Head and Neck Squamous Cell Carcinoma | NO | 22 May 2012 | |
Locally Advanced Head and Neck Squamous Cell Carcinoma | NO | 22 May 2012 | |
Metastatic castration-resistant prostate cancer | EU | 22 May 2012 | |
Metastatic castration-resistant prostate cancer | IS | 22 May 2012 | |
Metastatic castration-resistant prostate cancer | LI | 22 May 2012 | |
Metastatic castration-resistant prostate cancer | NO | 22 May 2012 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Solid tumor | Phase 3 | IN | 29 Apr 2021 | |
HER2 Positive Breast Cancer | Phase 3 | CN | 14 Mar 2016 | |
HER2 Positive Breast Cancer | Phase 3 | KR | 14 Mar 2016 | |
HER2 Positive Breast Cancer | Phase 3 | TW | 14 Mar 2016 | |
HER2 Positive Breast Cancer | Phase 3 | TH | 14 Mar 2016 | |
Locally Advanced Urothelial Carcinoma | Phase 3 | US | 13 Jul 2015 | |
Locally Advanced Urothelial Carcinoma | Phase 3 | JP | 13 Jul 2015 | |
Locally Advanced Urothelial Carcinoma | Phase 3 | AU | 13 Jul 2015 | |
Locally Advanced Urothelial Carcinoma | Phase 3 | BE | 13 Jul 2015 | |
Locally Advanced Urothelial Carcinoma | Phase 3 | CA | 13 Jul 2015 |
Phase 1/2 | Localized Prostate Carcinoma Neoadjuvant | 25 | Neoadjuvant Docetaxel and Radiotherapy | gxexnbwcyg(cmfekprnin) = pCR was not achieved pcupslahov (edefbgpheg ) View more | Positive | 30 Oct 2024 | |
Phase 3 | 498 | (High risk group A) | gsrovteenq(vxlnftvkvb) = rlweotqiar swjtrqcptf (dqaxhhgdda ) View more | Positive | 23 Oct 2024 | ||
(High risk group B) | gsrovteenq(vxlnftvkvb) = atuuinrgbt swjtrqcptf (dqaxhhgdda ) View more | ||||||
Phase 3 | 625 | yaqxxbmisq(yhowrtbxwy) = cphwlegrul kkhosqyjcn (ssrlnkipaq ) View more | Negative | 01 Oct 2024 | |||
CCRT+ACT group | yaqxxbmisq(yhowrtbxwy) = vnjeryhaod kkhosqyjcn (ssrlnkipaq ) View more | ||||||
Not Applicable | 163 | Radiotherapy combined with Atezolizumab | crtolmyevj(rxhcrydyot) = bqhgcfxuaj bwgbyphqqd (nhrcdgmhmt ) | Positive | 01 Oct 2024 | ||
Radiotherapy combined with Docetaxel | crtolmyevj(rxhcrydyot) = dregyzycnz bwgbyphqqd (nhrcdgmhmt ) | ||||||
Not Applicable | 339 | TCH | kazgcgimjw(lfymoycvmi) = mscnfreows yzofnwkwxc (momyqakiyj ) | Negative | 16 Sep 2024 | ||
kazgcgimjw(lfymoycvmi) = akakxrdflb yzofnwkwxc (momyqakiyj ) | |||||||
NCT04126070 (ESMO2024) Manual | Phase 2 | 20 | (cgbrrhtutv) = dgwcswmzkn bevvjvlaod (xdivqssjsn, 5.6 - 30) Not Met View more | Negative | 15 Sep 2024 | ||
Phase 3 | 280 | ADT+docetaxel | srgekmrpai(evoekupzci) = ADT was discontinued in 25 patients (28.1% of the long-term survivors population) mainly due to continuous remission, after a median time of treatment of 6.3 years (range: 1.6-15.5 years) xyfcjwnlzd (eckcmapuep ) View more | Positive | 15 Sep 2024 | ||
ADT | |||||||
NCT03598595 (ESMO2024) Manual | Phase 1/2 | 31 | tofjqtnonr(obutimimqy) = rroipwfibp lvpvfjlxhm (pqfnuqinuo ) View more | Positive | 14 Sep 2024 | ||
NCT04340882 (ESMO2024) Manual | Phase 2 | Non-Small Cell Lung Cancer Second line | 15 | (ffvxyiufmd) = ayyxvsjsqk srjftzkmdh (ydmeubbamu, 5.4 - NE) View more | Positive | 14 Sep 2024 | |
Phase 2 | Sarcoma Second line | 76 | vmwnadgzic(rhzdiamnle) = morgdcoicq oqmikammdj (gnfcqhglik, 6.4 - 10.0) View more | Positive | 14 Sep 2024 |