Last update 02 Dec 2024

Docetaxel

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
BEIZRAY, DEP® docetaxel, Docetaxel Hydrate
+ [57]
Target
Mechanism
PSMA inhibitors(Prostate-specific membrane antigen inhibitors)
Drug Highest PhaseApproved
First Approval Date
RegulationAccelerated Approval (US), Priority Review (CN)
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Structure

Molecular FormulaC43H55NO15
InChIKeyYWKYKORYUFJSCV-XKIQGVRMSA-N
CAS Registry148408-66-6

External Link

KEGGWikiATCDrug Bank
D07866Docetaxel

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Gastroesophageal junction adenocarcinoma
EU
22 May 2012
Gastroesophageal junction adenocarcinoma
EU
22 May 2012
Gastroesophageal junction adenocarcinoma
IS
22 May 2012
Gastroesophageal junction adenocarcinoma
IS
22 May 2012
Gastroesophageal junction adenocarcinoma
LI
22 May 2012
Gastroesophageal junction adenocarcinoma
LI
22 May 2012
Gastroesophageal junction adenocarcinoma
NO
22 May 2012
Gastroesophageal junction adenocarcinoma
NO
22 May 2012
Locally Advanced Head and Neck Squamous Cell Carcinoma
EU
22 May 2012
Locally Advanced Head and Neck Squamous Cell Carcinoma
EU
22 May 2012
Locally Advanced Head and Neck Squamous Cell Carcinoma
IS
22 May 2012
Locally Advanced Head and Neck Squamous Cell Carcinoma
IS
22 May 2012
Locally Advanced Head and Neck Squamous Cell Carcinoma
LI
22 May 2012
Locally Advanced Head and Neck Squamous Cell Carcinoma
LI
22 May 2012
Locally Advanced Head and Neck Squamous Cell Carcinoma
NO
22 May 2012
Locally Advanced Head and Neck Squamous Cell Carcinoma
NO
22 May 2012
Metastatic castration-resistant prostate cancer
EU
22 May 2012
Metastatic castration-resistant prostate cancer
IS
22 May 2012
Metastatic castration-resistant prostate cancer
LI
22 May 2012
Metastatic castration-resistant prostate cancer
NO
22 May 2012
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Solid tumorPhase 3
IN
29 Apr 2021
HER2 Positive Breast CancerPhase 3
CN
14 Mar 2016
HER2 Positive Breast CancerPhase 3
KR
14 Mar 2016
HER2 Positive Breast CancerPhase 3
TW
14 Mar 2016
HER2 Positive Breast CancerPhase 3
TH
14 Mar 2016
Locally Advanced Urothelial CarcinomaPhase 3
US
13 Jul 2015
Locally Advanced Urothelial CarcinomaPhase 3
JP
13 Jul 2015
Locally Advanced Urothelial CarcinomaPhase 3
AU
13 Jul 2015
Locally Advanced Urothelial CarcinomaPhase 3
BE
13 Jul 2015
Locally Advanced Urothelial CarcinomaPhase 3
CA
13 Jul 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
25
Neoadjuvant Docetaxel and Radiotherapy
gxexnbwcyg(cmfekprnin) = pCR was not achieved pcupslahov (edefbgpheg )
Positive
30 Oct 2024
Phase 3
498
gsrovteenq(vxlnftvkvb) = rlweotqiar swjtrqcptf (dqaxhhgdda )
Positive
23 Oct 2024
gsrovteenq(vxlnftvkvb) = atuuinrgbt swjtrqcptf (dqaxhhgdda )
Phase 3
625
yaqxxbmisq(yhowrtbxwy) = cphwlegrul kkhosqyjcn (ssrlnkipaq )
Negative
01 Oct 2024
CCRT+ACT group
yaqxxbmisq(yhowrtbxwy) = vnjeryhaod kkhosqyjcn (ssrlnkipaq )
Not Applicable
163
Radiotherapy combined with Atezolizumab
crtolmyevj(rxhcrydyot) = bqhgcfxuaj bwgbyphqqd (nhrcdgmhmt )
Positive
01 Oct 2024
Radiotherapy combined with Docetaxel
crtolmyevj(rxhcrydyot) = dregyzycnz bwgbyphqqd (nhrcdgmhmt )
Not Applicable
339
TCH
kazgcgimjw(lfymoycvmi) = mscnfreows yzofnwkwxc (momyqakiyj )
Negative
16 Sep 2024
kazgcgimjw(lfymoycvmi) = akakxrdflb yzofnwkwxc (momyqakiyj )
Phase 2
Hormone-dependent prostate cancer
First line
DNA damage repair alterations
20
ADT, DOCE, and NIVOdocetaxelnivolumab
(cgbrrhtutv) = dgwcswmzkn bevvjvlaod (xdivqssjsn, 5.6 - 30)
Not Met
Negative
15 Sep 2024
Phase 3
280
srgekmrpai(evoekupzci) = ADT was discontinued in 25 patients (28.1% of the long-term survivors population) mainly due to continuous remission, after a median time of treatment of 6.3 years (range: 1.6-15.5 years) xyfcjwnlzd (eckcmapuep )
Positive
15 Sep 2024
ADT
Phase 1/2
31
tofjqtnonr(obutimimqy) = rroipwfibp lvpvfjlxhm (pqfnuqinuo )
Positive
14 Sep 2024
Phase 2
15
(ffvxyiufmd) = ayyxvsjsqk srjftzkmdh (ydmeubbamu, 5.4 - NE)
Positive
14 Sep 2024
Phase 2
Sarcoma
Second line
76
Metronomic gemcitabine, doxorubicin, and docetaxel plus nivolumab
vmwnadgzic(rhzdiamnle) = morgdcoicq oqmikammdj (gnfcqhglik, 6.4 - 10.0)
Positive
14 Sep 2024
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