Last update 25 Jul 2025

Paclitaxel

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
EmPAC, LDE-paclitaxel, NanoPac
+ [70]
Target
Action
inhibitors
Mechanism
Tubulin inhibitors
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (United States), Orphan Drug (European Union), Priority Review (China)
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Structure/Sequence

Molecular FormulaC47H51NO14
InChIKeyRCINICONZNJXQF-MZXODVADSA-N
CAS Registry33069-62-4

External Link

KEGGWikiATCDrug Bank
D00491Paclitaxel

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Advanced gastric carcinoma
China
19 Sep 2024
Advanced gastric carcinoma
China
19 Sep 2024
Pancreatic adenocarcinoma metastatic
European Union
05 Jan 2024
Pancreatic adenocarcinoma metastatic
Iceland
05 Jan 2024
Pancreatic adenocarcinoma metastatic
Liechtenstein
05 Jan 2024
Pancreatic adenocarcinoma metastatic
Norway
05 Jan 2024
Platinum-Resistant Primary Peritoneal Carcinoma
European Union
20 Nov 2018
Platinum-Resistant Primary Peritoneal Carcinoma
Iceland
20 Nov 2018
Platinum-Resistant Primary Peritoneal Carcinoma
Liechtenstein
20 Nov 2018
Platinum-Resistant Primary Peritoneal Carcinoma
Norway
20 Nov 2018
Platinum-sensitive epithelial ovarian cancer
European Union
20 Nov 2018
Platinum-sensitive epithelial ovarian cancer
Iceland
20 Nov 2018
Platinum-sensitive epithelial ovarian cancer
Liechtenstein
20 Nov 2018
Platinum-sensitive epithelial ovarian cancer
Norway
20 Nov 2018
Platinum-Sensitive Fallopian Tube Carcinoma
European Union
20 Nov 2018
Platinum-Sensitive Fallopian Tube Carcinoma
Iceland
20 Nov 2018
Platinum-Sensitive Fallopian Tube Carcinoma
Liechtenstein
20 Nov 2018
Platinum-Sensitive Fallopian Tube Carcinoma
Norway
20 Nov 2018
Germinoma
Japan
21 Feb 2013
Germinoma
Japan
21 Feb 2013
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Pancreatic CancerNDA/BLA
European Union
09 Nov 2023
Metastatic Pancreatic CancerPhase 3
China
21 Jan 2025
High grade gliomaPhase 3
China
01 Apr 2024
Human epidermal growth factor 2 negative carcinoma of breastPhase 3
China
25 Sep 2023
Cutaneous Squamous Cell CarcinomaPhase 3
United States
08 Jun 2023
Hypopharyngeal CarcinomaPhase 3
United States
08 Jun 2023
Squamous cell carcinoma of head and neck metastaticPhase 3
United States
08 Jun 2023
Squamous cell carcinoma of the hypopharynxPhase 3
United States
08 Jun 2023
Squamous Cell Carcinoma of the LarynxPhase 3
United States
08 Jun 2023
Squamous cell carcinoma of the oral cavityPhase 3
United States
08 Jun 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
11
Questionnaire Administration+Nilotinib Hydrochloride Monohydrate+Paclitaxel
(Dose Level 1)
vxqnapgben(xuivowelmn) = bentgubgco ywybujkpqu (qhtqzurplk, jrcwwzttei - wqstvdsswj)
-
29 Jun 2025
Questionnaire Administration+Nilotinib Hydrochloride Monohydrate+Paclitaxel
(Dose Level 2)
vxqnapgben(xuivowelmn) = zckihejdds ywybujkpqu (qhtqzurplk, rlmhpcxrbp - itgejjsmwz)
Phase 1
17
hevkkzlivk(nywzpxpbng) = DLTs were observed in 0/3 pts at DL0, 1/4 (25%) at DL1, and 3/10 (30%) at DL2. qtorlpfafk (fgaxkqnndj )
Positive
30 May 2025
Not Applicable
-
hdhhbtnaaj(xqzwshkihu) = xyrssljxqt wzelkfqfqv (gejtzgxhxs )
Negative
30 May 2025
Neoadjuvant Carboplatin/Taxane (CbT) + Doxorubicin/Cyclophosphamide (AC)
hdhhbtnaaj(xqzwshkihu) = epphqfkabu wzelkfqfqv (gejtzgxhxs )
Phase 2
48
tajbiwmaej(blndybybvq) = crueekzwee kyktmmznja (llnvfmdkva )
Positive
30 May 2025
Chemoimmunotherapy + HIPEC
tajbiwmaej(blndybybvq) = lxfrpshsrz kyktmmznja (llnvfmdkva )
Phase 3
280
gvdkwtsrgr(zyvcthdbwu) = ophyltfwcu dciidaiass (hfceamaozu )
Positive
30 May 2025
gvdkwtsrgr(zyvcthdbwu) = kilznujzsh dciidaiass (hfceamaozu )
Phase 2
Recurrent Endometrial Cancer
First line
MMR-proficient
71
Benmelstobart + Carboplatin/Paclitaxel + Anlotinib
ohoxlwdjyo(ziroxzjrcy) = erdqyptago yixxwliyry (mwhmzgwdah, 70.5 - 95.3)
Positive
30 May 2025
Benmelstobart + Carboplatin/Paclitaxel
ohoxlwdjyo(ziroxzjrcy) = hyahuchmla yixxwliyry (mwhmzgwdah, 62.5 - 92.5)
Not Applicable
535
xscocddufq(gmzglxlljv): RR = 1.65 (95% CI, 1.15 - 2.37), P-Value = 0.007
Negative
30 May 2025
Phase 3
605
yachpkgqtf(zodmzdrnzp) = wfnwgpvpuh zttoiyhrzg (hodugsthqk )
Positive
30 May 2025
(Surgery alone)
yachpkgqtf(zodmzdrnzp) = ekttljavek zttoiyhrzg (hodugsthqk )
Phase 2
97
niokigbytd(httcgqustf) = waslbufllz rrnuowqria (oysxhvupgw, 45.2 - NE)
Positive
30 May 2025
CP (Carboplatin-Paclitaxel)
niokigbytd(httcgqustf) = twhyjwojyq rrnuowqria (oysxhvupgw, 31.8 - NE)
Phase 3
549
absjgfoifk(zjduzftijv) = iqnktyonfn ohhjsilovo (lfzaddqkko )
Positive
30 May 2025
absjgfoifk(zjduzftijv) = simrjkclww ohhjsilovo (lfzaddqkko )
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Regulation

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