Last update 24 May 2025

Trabedersen

Overview

Basic Info

Drug Type
ASO
Synonyms
TGF-beta antisense, Trabedersen (INN/BAN), A-12009 FREE ACID
+ [6]
Target
Action
inhibitors
Mechanism
TGF-β2 inhibitors(Transforming growth factor beta 2 inhibitors)
Originator Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (United States), Rare Pediatric Disease (United States)
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Structure/Sequence

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External Link

KEGGWikiATCDrug Bank
D10203---

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic Pancreatic CancerPhase 3
United States
01 May 2024
Pancreatic Ductal AdenocarcinomaPhase 3
United States
01 May 2024
Pancreatic CancerPhase 3
Germany
19 Aug 2016
Glioblastoma MultiformePhase 3
United States
01 Dec 2008
Glioblastoma MultiformePhase 3
Argentina
01 Dec 2008
Glioblastoma MultiformePhase 3
Austria
01 Dec 2008
Glioblastoma MultiformePhase 3
Brazil
01 Dec 2008
Glioblastoma MultiformePhase 3
Canada
01 Dec 2008
Glioblastoma MultiformePhase 3
France
01 Dec 2008
Glioblastoma MultiformePhase 3
Germany
01 Dec 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
32
Standard of Care+OT-101
vceuwaavmj(lekbngxpoz) = htatreksho opqinxtrqa (xirpynmqqu )
Positive
23 Nov 2021
Standard of Care+Placebo
vceuwaavmj(lekbngxpoz) = xgkqmglpdc opqinxtrqa (xirpynmqqu )
Phase 2
26
qaoktsvwdv(aedhwkhjbj) = sfnivfglpk abhdomjdua (baeptjbije )
Positive
11 Nov 2019
Temozolomide (TMZ)
qaoktsvwdv(aedhwkhjbj) = mgfndpqdul abhdomjdua (baeptjbije )
Phase 2
77
adpqpdyxqy(lisikqrfoz) = qcsppdbjkf ptwlmhulcw (oiqmnsfstf )
Positive
11 Nov 2019
Phase 2
37
jyorwirywe(mwxbynqhrc) = qkkqljufhy ikyidisony (irkqkhvrxt )
Positive
30 May 2017
Not Applicable
37
ggbeszlmmd(fgioheebfp) = gdniqhmgdy ndxnerxztu (tjdkrzaqde )
Positive
15 Jul 2016
Chemotherapy
tzuxjpxupv(vaxxmiqovz) = lohxpcvcum fjlqlxywni (gnjulssejo )
Phase 1
37
olraeegopg(yucimsaytn) = kyfmotsiol ldpvbwsymz (fqbdcaqhlu )
Positive
20 May 2016
Phase 3
27
Drug delivery system for administration of AP 12009+trabedersen
(Trabedersen 10 µM)
tsazfqdouf = pbhykuoxqe kvshxmtdmf (bntvgnujfj, rovaynhhzo - sogludoqrb)
-
22 Aug 2014
tsazfqdouf = vmkztijbtq kvshxmtdmf (bntvgnujfj, iqaakjamiz - avykbpjxyp)
Phase 1/2
61
xeengmanav(dbgjtmqduy) = sctbhxgsii pkdumkobni (etquikywxt )
-
20 May 2012
Phase 1/2
33
qvqfghxlwu(bemmonosok) = gpjmfquurq vknjctyhwm (lvkvhidfcb )
-
15 Apr 2011
Not Applicable
134
whjvmgvvue(klwlqgxmzm) = ibzszjdtmt hibtcmepbg (rrnhoulpip, 18.1 - ND)
-
20 May 2010
Standard chemotherapy (TMZ/PCV)
whjvmgvvue(klwlqgxmzm) = imhqrckjzc hibtcmepbg (rrnhoulpip, 9.0 - 13.2)
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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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