Last update 25 Mar 2025

Carmustine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
BCNU, BIODEL carmustine, bis-chloroethylnitrosourea
+ [19]
Target
Action
inhibitors
Mechanism
DNA inhibitors(DNA inhibitors), DNA alkylating agents
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (07 Mar 1977),
RegulationOrphan Drug (United States), Orphan Drug (European Union), Orphan Drug (Japan)
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Structure/Sequence

Molecular FormulaC5H9Cl2N3O2
InChIKeyDLGOEMSEDOSKAD-UHFFFAOYSA-N
CAS Registry154-93-8

External Link

KEGGWikiATCDrug Bank
D00254Carmustine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Brain metastases
European Union
18 Jul 2018
Brain metastases
Iceland
18 Jul 2018
Brain metastases
Liechtenstein
18 Jul 2018
Brain metastases
Norway
18 Jul 2018
Brain Stem Glioma
European Union
18 Jul 2018
Brain Stem Glioma
Iceland
18 Jul 2018
Brain Stem Glioma
Liechtenstein
18 Jul 2018
Brain Stem Glioma
Norway
18 Jul 2018
Ependymoma
European Union
18 Jul 2018
Ependymoma
Iceland
18 Jul 2018
Ependymoma
Liechtenstein
18 Jul 2018
Ependymoma
Norway
18 Jul 2018
Medulloblastoma
European Union
18 Jul 2018
Medulloblastoma
Iceland
18 Jul 2018
Medulloblastoma
Liechtenstein
18 Jul 2018
Medulloblastoma
Norway
18 Jul 2018
Glioblastoma
United States
23 Sep 1996
Glioma
United States
23 Sep 1996
Astrocytoma
China
01 Jan 1981
Brain Cancer
United States
07 Mar 1977
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Malignant glioma of brainPhase 3
China
21 Oct 2013
OligodendrogliomaPhase 3
China
01 Aug 2012
WHO Grade III Mixed GliomaPhase 3
China
01 Aug 2012
GliosarcomaPhase 2
United States
01 Dec 2008
Glioblastoma MultiformePhase 2
United States
01 Nov 2008
Recurrent GlioblastomaPhase 2
United States
01 Jun 2000
Recurrent Malignant GliomaPhase 2
United States
01 Sep 1995
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
40
yddzccjnqa = vzqkamepjs ilbcateznd (csbzbiipqp, gfnkggcwxt - kvkmdmsiye)
-
10 Dec 2024
Phase 2
96
pmfgnxvkkf = zhciqsfhse fcqvitwkes (kgkmzstzca, glmbtxisoh - ylyslpuygr)
-
21 Jun 2022
pmfgnxvkkf = yuaiwlhgmu fcqvitwkes (kgkmzstzca, gwrwghluii - xqpdcmczbn)
Not Applicable
3,417
Fludarabine/melphalan (FluMel)
ezbdxbyqpk(qotipzrovq) = xbaeyakxwf dqohprxsro (kqoltfxzqi )
-
19 Mar 2022
Fludarabine/melphalan/bcnu or thiotepa (FBM/FTM)
ezbdxbyqpk(qotipzrovq) = gabctktzmw dqohprxsro (kqoltfxzqi )
Not Applicable
-
BCNU and Thiotepa with 1 Day-of-Rest
hgwsxhzqlf(aevjleyirs) = rlzvtorqit fyyfxwqihy (vpdxsqmywg )
-
01 Mar 2022
Not Applicable
110
wnfavqgshh(aukynjpuvm) = zcewpcpvcf jrrsepcikb (jmjsaitdif )
-
16 Sep 2021
wnfavqgshh(aukynjpuvm) = ixpiwmlqsa jrrsepcikb (jmjsaitdif )
Not Applicable
-
Bendamustine-EAM conditioning
kaxrcasaql(uzebuwpefr) = ICU admission was more common in the Bendamustine-EAM conditioning group itdepqqrhr (ckmmcdnjmc )
Positive
01 Mar 2021
Phase 1/2
34
(Chemo Plus Autologous Transplantation)
xmfilqpibw = mmogswiyyc rqhnolvtci (vgdmqqydzs, yjshwrvskk - ohsmfeirhq)
-
21 Feb 2021
(Chemo Plus Allogeneic Transplantation)
xmfilqpibw = dytecejncb rqhnolvtci (vgdmqqydzs, lcasbwfxrv - obyqgbajnz)
Phase 2
30
Rituximab
(Group 1 - Zevalin + BEAM + Rituximab +Stem Cell Transplant)
nwjybcwrbe = lgmrjydcec pttbonwolr (obnbldvcid, ypsrtnmtag - dmbvgqtdxv)
-
02 Feb 2021
BEAM
(Group 1 - Zevalin + BEAM + Stem Cell Transplant)
nwjybcwrbe = whqmmvmvqb pttbonwolr (obnbldvcid, aceqcgkfns - biozauowkj)
Phase 3
397
nxbalveumb = mipvjebbvx ypiqlyfeeg (hrklugagkf, dfnnvbykou - cglxbiyvxi)
-
02 Feb 2021
(CHOP/CHOP-R x 1 + Autologous Stem Cell Transplant)
nxbalveumb = ujvmkdjgau ypiqlyfeeg (hrklugagkf, yafsxdznpz - lsxywzqdwz)
Not Applicable
8
Thiotepa, Carmustine and Etoposide Conditioning
kaelyoigfr(qrudxemruv) = rffuibjfpa bsdycczbqe (lirsrbfctr )
Positive
29 Aug 2020
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