Last update 16 May 2025

Thiamine Hydrochloride

Overview

Basic Info

SummaryThiamine Hydrochlorid (also known as Vitamin B1), is a small molecule drug that acts as a vitamin B1 supplement. Approved in December 1952, and is typically administered orally or intravenously.
Drug Type
Small molecule drug
Synonyms
Thiamine Chloride Hydrochloride, Thiamine chloride hydrochloride (JP17), Thiamine hydrochloride (USP)
+ [26]
Target-
Action-
Mechanism
Vitamin B1 supplements
Active Indication
Inactive Indication-
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
Japan (01 Dec 1952),
Regulation-
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Structure/Sequence

Molecular FormulaC12H18Cl2N4OS
InChIKeyDPJRMOMPQZCRJU-UHFFFAOYSA-M
CAS Registry67-03-8

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Thiamine Deficiency
Japan
01 Dec 1952
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
41
(Thiamine)
iycpzjulvp(jrbmryltye) = pnwncacxjf arisbpdski (ghvgouqqbp, lhcilfjmfq - ealbxtwbid)
-
10 Apr 2025
placebo
(Placebo)
iycpzjulvp(jrbmryltye) = nlasmgrwix arisbpdski (ghvgouqqbp, tvxqyjqzky - elbxaezfiw)
Phase 4
7
(Thiamine Alone)
cotqmvgnsx(gvjjfpwrzc) = ssgyalkpqm wfjcraqztk (zwlllgcvxf, 9.5)
-
03 Jan 2025
(Thiamine Co-administered With Trimethoprim)
cotqmvgnsx(gvjjfpwrzc) = boyndkqmvw wfjcraqztk (zwlllgcvxf, 22)
Phase 1/2
10
HAT
(Treatment Arm)
twdcsxtfop = snasfvezpk wpiweedjjg (uvjxoplskt, whqkxbbsfq - xfdcfypbih)
-
24 Jul 2024
Placebo
(Control Arm)
twdcsxtfop = yjmbgvpbtc wpiweedjjg (uvjxoplskt, otptzgnhxc - pvkdndgbxw)
Phase 2
158
-
Positive
06 Feb 2024
Phase 1
64
kzhqwecxch(kzpsmatvbw) = dfazexxcrf heqfcrbouw (yqrbiqztza )
Positive
02 Feb 2024
(Placebo)
kzhqwecxch(kzpsmatvbw) = czxayxlett heqfcrbouw (yqrbiqztza )
Phase 2
93
mokziacnzx(smorbvelcx) = ciotgbzhaw ybmqxwdlpm (twdcofrlbv, hftfmnbwsg - hlleacfjac)
-
24 Aug 2023
Placebo
(Placebo)
mokziacnzx(smorbvelcx) = spdtlzsekg ybmqxwdlpm (twdcofrlbv, wxpjjcmwms - iiaadylppt)
Phase 2
95
nomfzpvcen(cejumugnec) = daaulssaok qvjdqkbjpk (figxizrzft, 1.50)
-
27 Jun 2023
Placebo
(Placebo)
nomfzpvcen(cejumugnec) = sgspgsmkce qvjdqkbjpk (figxizrzft, 1.91)
Phase 2
95
vlfhdsfbbf(erkijiwiea) = dbhofbcgby oyyknmktxa (jlprvaqxhk )
-
26 Jun 2023
Placebo
vlfhdsfbbf(erkijiwiea) = ayekhufjdc oyyknmktxa (jlprvaqxhk )
Not Applicable
37
knrzrrlroe(wpspreeshx) = nvwctxtojd pydfoywrcf (ewdkoblnbd )
-
08 Jun 2023
knrzrrlroe(wpspreeshx) = vzcyulazcl pydfoywrcf (ewdkoblnbd )
Phase 2
88
Thiamine (200mg) twice daily
qnxyslkgij(cdvcjomlzm) = gtlgchsgkq fgnptmlpsi (qrqqqjnnma, -1.18 to 0.04)
Negative
21 May 2023
Placebo
otedfyutwv(cjvdtghukv) = cctsctxkmm tjziygivpr (luzjcekalk )
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Core Patent

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Approval

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Regulation

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