A Phase II, Open Label, Randomized Controlled Pilot Study Evaluating Trimethoprim in Patients Commencing Androgen Deprivation Therapy for Prostate Cancer

The researchers hope to learn if Trimethoprim, 150mg taken daily for 3 months, is a safe and effective way to reduce folate levels at time of Androgen Deprivation Therapy (ADT) in men with advanced prostate cancer.
This study will help find out what effects, good and/or bad, this drug has on people who take it and on its effect on the disease. The safety of this drug in humans has been tested in prior research studies; however, some side effects may not yet be known.

Start Date01 Jun 2025

Sponsor / Collaborator

University of Texas Health Science Center At San Antonio

NCT06709196

/ RecruitingPhase 4IIT

REINFORCE - Reducing Infection-related Readmissions Following Cystectomy. a Multicentre Randomised Clinical Trial Testing Superiority of Individualised Targeted Antibiotic Prophylaxis Over Empiric Prophylaxis At Ureteral Stent Removal to Reduce Infection-related Readmissions Following Cystectomy.

The aim of this trial is to test whether postoperative antibiotics targeted towards bacteria in the urine can reduce the risk of infection after surgical removal of the bladder (cystectomy) compared to a standardised antibiotic prophylaxis.
Participants undergoing cystectomy will be randomly assigned to postoperatively receive (A) a standardised orally administered antibiotic prophylaxis currently given at Rigshospitalet, Copenhagen or (B) a conventional orally administered antibiotic prophylaxis targeting bacteria found in the urine postoperatively.
The investigators' hypothesis is that the targeted prophylactic antibiotic strategy will reduce the number of infection-related readmissions within 90 days of surgery compared to the standardised prophylaxis.

Start Date07 Jan 2025

Sponsor / Collaborator

Rigshospitalet

ChiCTR2200066181

/ RecruitingPhase 4IIT

A study on the effect of trimethoprim plus thioglycollate gel filling for the prevention of postoperative stricture in large esophageal ESD

Start Date14 Nov 2022

Sponsor / Collaborator-

100 Clinical Results associated with Trimethoprim

100 Translational Medicine associated with Trimethoprim

100 Patents (Medical) associated with Trimethoprim

31,164

Literatures (Medical) associated with Trimethoprim

31 Dec 2025·Organogenesis

Tetramethylpyrazine Confers Protection Against Oxidative Stress and NLRP3-Dependent Pyroptosis in Rats with Endometriosis

Article

Author: Xu, Ke ; Wang, Mingyang ; Zou, Xiaofeng ; Zhang, Mingzhe

Tetramethylpyrazine (TMP) has been confirmed to suppress inflammation in endometriosis (EMs). Herein, this study investigated whether and how TMP affected NLRP3 inflammasomes and oxidative stress in EMs. After establishment of an EMs rat model, rats were treated with different concentrations of TMP. The size of endometriotic lesions and the latency and frequency of torsion in rats were recorded, followed by the measurement of relevant indicators (TNF-α, IL-6, IL-2, IL-10, MDA, SOD, GSH, CAT, ROS, NLRP3, ASC, GSDMD, caspase-1, Nrf2, and HO-1). The study experimentally determined that TMP treatment markedly decreased the size of endometriotic lesions and improved torsion in rats with EMs. The levels of inflammatory proteins, oxidative stress markers, NLRP3 inflammasome, and pyroptotic proteins were elevated in rats with EMs, all of which were reversed upon TMP treatment. Additionally, the activities of SOD, GSH, and CAT were lowered in rats with EMs, which were partly abrogated by TMP treatment. Furthermore, the downregulation of Nrf2 and HO-1 was counteracted by TMP treatment. To sum up, TMP represses excessive oxidative stress, NLRP3 inflammasome activation, and pyroptosis in rats with EMs. Additionally, TMP may activate the Nrf2/HO-1 pathway.

01 Dec 2025·MOLECULAR BIOLOGY REPORTS

Prevalence and characteristics of ST131-O16 and ST131-O25b clones among extended-spectrum β-lactamase-producing Escherichia coli isolates causing bloodstream infection in Iran

Article

Author: Rahdar, Hossein Ali ; Jabalameli, Fereshteh ; Ebrahimi, Mohammad Taha ; Yavari-Bafghi, Maryam ; Beigverdi, Reza ; Emaneini, Mohammad ; Halimi, Shahnaz

BACKGROUND:

The multidrug-resistant clone identified as Escherichia coli sequence type 131 (E. coli ST131) has spread worldwide. The current study is one of the first comprehensive investigations to ascertain the prevalence of ST131 and molecularly characterize the ST131-O25b and ST131-O16 subgroups causing bloodstream infections in Iran.

METHODS AND RESULTS:

To this end, 119 consecutive, non-repetitive E. coli clinical strains were isolated from blood samples of patients with septicemia in different hospital wards for one year in Tehran. The isolates were provided by the laboratories of tertiary hospitals affiliated with Tehran University of Medical Sciences. The disk diffusion method was used to investigate the sensitivity of bacteria to antibiotics. All phylogroup B2 isolates were screened for E. coli ST131 status using a triplex PCR assay that combines the identification of ST131-O25b and -O16 clades. The seven putative virulence factor genes (kpmstII, fimH, afa A, iroN, Sat, ibeA, and ompT) and resistance genes (bla_CTX-M-15, bla_OXA-48, and bla_CMY) were detected by PCR in E. coli ST131 isolates.

CONCLUSIONS:

The highest incidence of antibiotic resistance among 74/119 (62.18%) extended-spectrum β-lactamases-producing E. coli isolates was observed, respectively, against Nalidixic acid (82%), and Aztreonam (75%), followed by Ciprofloxacin (70%). Twenty out of 74 ESBL-producing E. coli isolates were found to be ST131 (27%), with 13 (65%) ST131-O25b and 7 (35%) ST131-O16 clades, respectively. The ST131-O16 isolates had a higher prevalence of resistance to Ceftriaxone, Amikacin, Aztreonam, and Cefepime than the -O25b ones. Concerning virulence capacity, our findings demonstrated that kpmstII, fimH, and ompT genes were found in 85%, 65%, and 30% of ST131 isolates, respectively. Our results reinforce the surveillance of E. coli ST131 clone dissemination as a major drug-resistant pathogen and an important new public health threat in Iran. Accumulation of multiple virulence factors, ESBL carriage, and identified antimicrobial resistance patterns of ST131-O25b and ST131-O16 clones indicate a necessity to develop strategies to control the spread of these isolates in both community and hospital settings.

01 Jul 2025·AMERICAN JOURNAL OF EMERGENCY MEDICINE

Epidemiology of urinary tract infections in adults among United States emergency departments from 2016 to 2023

Article

Author: Gottlieb, Michael ; Amponsah, Tamara ; Moyer, Eric ; Bernard, Kyle

INTRODUCTION:

Infections of the urinary tract, including cystitis and pyelonephritis, are common reasons for presentation to the Emergency Department (ED). However, there are limited recent data on incidence and admission rates. Moreover, with changes in resistance rates, advances in antibiotic options, and increasing antimicrobial stewardship, there is a need to better understand the current management. This study reports the incidence, admission rates, and antibiotic distribution among a nationwide cohort of adult ED patients with cystitis and pyelonephritis over an eight-year period.

METHODS:

This was a cross-sectional study of adult ED patients with a diagnosis of cystitis or pyelonephritis from 1/1/2016 to 12/31/2023. Using the Epic Cosmos database, ED visits for the above were identified using ICD-10 codes. Outcomes included total ED presentations, admission rates, outpatient antibiotic prescriptions, and antibiotics administered in the ED for admitted patients with cystitis or pyelonephritis. Data were analyzed with binary logistic regression models to measure the relationship between time and dependent variables.

RESULTS:

There were 205,526,173 total ED encounters, with cystitis occurring in 8,768,481 (4.3 %) and pyelonephritis in 1,044,742 (0.5 %). 23.9 % of those with cystitis were admitted and 33.4 % of those with pyelonephritis were admitted, with a slight rise over time. The most common antibiotics for patients admitted with cystitis and pyelonephritis were third-generation cephalosporins (50.6 % and 55.6 %, respectively). There was a rise in third-generation and fourth-generation cephalosporins, while fluoroquinolone use declined. For discharged patients with cystitis, the most common antibiotics were first-generation cephalosporins (36.4 %), nitrofurantoin (17.9 %), and trimethoprim/sulfamethoxazole (10.7 %). There was a rise in first-generation, second-generation, and third-generation cephalosporins, while nitrofurantoin, trimethoprim/sulfamethoxazole, and ciprofloxacin use declined. For discharged patients with pyelonephritis, the most commonly prescribed antibiotics were first-generation cephalosporins (28.6 %), third-generation cephalosporins (19.5 %), ciprofloxacin (17.0 %), and trimethoprim/sulfamethoxazole (11.5 %). The largest rise was in third-generation cephalosporins, while there was a decline in fluoroquinolones.

CONCLUSION:

Cystitis and pyelonephritis remain common ED presentations with a rise over time. There have been notable shifts in antibiotics, with an overall increase in cephalosporins while fluoroquinolone use has declined. Understanding the current epidemiology can inform public health planning and antibiotic stewardship in the ED.

News (Medical) associated with Trimethoprim

08 Jan 2025

·www.echemi.com

80 batches of drugs recalled urgently! A major decision by the National Medical Products Administration

Recently, the National Medical Products Administration announced an important decision to stop the production, sale, and use of Hyoscine Butylbromide Tablets, and to revoke its drug registration certificate. According to the announcement issued by the National Medical Products Administration on January 3, titled “Announcement on the Revocation of the Drug Registration Certificate for Hyoscine Butylbromide Tablets (2025 No. 2)”, Hyoscine Butylbromide Tablets, an antibacterial drug also known as Loperamide, will no longer circulate in the market of our country. This decision is effective immediately, and the products already on the market will be recalled by the marketing authorization holder and supervised by provincial drug regulatory authorities for destruction or other harmless disposal measures. A total of 80 batches of Hyoscine Butylbromide Tablets are involved. In addition, in another announcement issued by the National Medical Products Administration on December 2, 2024, it was also announced that 58 drug registration certificates, including 11 batches of Hyoscine Butylbromide Tablets, have been revoked. Based on Article 83 of the Drug Administration Law of the People's Republic of China and other relevant regulations, these drugs have been required to stop production and sale due to unclear efficacy, serious adverse reactions, or other hazards to human health. Hyoscine Butylbromide Tablets are a compound preparation, with the main active ingredients including Hyoscine Tincture, Sulfamethoxazole, and Trimethoprim, primarily used to treat dysentery caused by Shigella and other sensitive pathogenic bacteria causing enteritis. However, with the withdrawal of this drug from the market, other drugs such as Montmorillonite Powder will take on the responsibility for treating diarrhea. According to data from Miiine, the incidence of gastrointestinal diseases is on the rise and is becoming more prevalent among younger populations. In the first three quarters of 2022, the sales of anti-diarrheal drugs and intestinal anti-inflammatory/infection drugs in public hospitals in key provinces and cities in China exceeded 1.2 billion yuan, a year-on-year increase of 6.30%. The sales scale of Montmorillonite Powder in the three major terminal markets in China has exceeded 1 billion yuan, with the outpatient market being the main sales channel, rising by 60%, making it the Top 2 product in anti-diarrheal and intestinal anti-inflammatory/infection drugs. Statistics from Cyborg Blue show that 145 drug registration certificates were revoked in 2024. In the announcement on December 2, 2024, in addition to Hyoscine Butylbromide Tablets, it also included 3 batches of Losartan Potassium Tablets, 2 batches of Phenazone Tablets, 2 batches of Amlodipine Besylate Tablets, 2 batches of Entecavir Tablets, 2 batches of Compound Snake Gall and Chuan Bei Powder, and 2 batches of Rifampicin Capsules. Phenazone, as a pyrazolone analgesic and antipyretic, was launched early in our country, but its injection and nasal drops have severe adverse reactions, with risks outweighing benefits, and alternative medications are available, leading to its registration certificate being revoked in 2020. Although oral preparations like Phenazone Tablets still have certain clinical value, the National Medical Products Administration has implemented risk control measures by revising the instructions to add safety warnings, restricting applicable populations and indications. In the domestic market for antipyretic and analgesic drugs, Phenazone has a low market share and is declining. Data from Cyborg Blue shows that there are 861 approvals for "Phenazone Tablets," involving many companies and intense market competition. As related drug approvals are revoked, this market will face further fragmentation. Finally, according to the relevant provisions of the Regulations on the Implementation of the Drug Administration Law of the People's Republic of China and the Drug Registration Management Measures, the National Medical Products Administration decided on April 11, 2024, to revoke the registration certificates for 87 drugs, including Pancreatin Injection. Cyborg Blue’s analysis found that drugs such as 7 batches of Iohexol Injection, 6 batches of Insulin Glargine Injection, 4 batches of Detemir Insulin Injection, 4 batches of Vardenafil Hydrochloride Tablets, and 3 batches of Brain Protein Hydrolysate Injection were also revoked. Please note that the number of drugs counted in the text has not been deduplicated. No. Marketing Authorization Holder Approval Number 1 Shijiazhuang Lesheng Pharmaceutical Co., Ltd. SFDA H13023949 2 Jiangzhong Pharmaceutical Co., Ltd. SFDA H36022316 3 Shijiazhuang Fourth Pharmaceutical Co., Ltd. SFDA H13023932 4 Shijiazhuang Grey Pharmaceutical Co., Ltd. SFDA H13023934 5 Handan Bailin Pharmaceutical Co., Ltd. SFDA H13023945 6 Hebei Yongfeng Pharmaceutical Co., Ltd. SFDA H13023943 7 China National Pharmaceutical Group Wuhan Zhonglian Fourth Pharmaceutical Co., Ltd. SFDA H42022497 8 Jiangsu Enhua Pharmaceutical Co., Ltd. SFDA H32025932 9 Jiangxi Hongshuo Pharmaceutical Co., Ltd. SFDA H36022013 10 Jiangxi Hongshuo Pharmaceutical Co., Ltd. SFDA H36022244 11 Jiangsu Chenpai Pharmaceutical Group Co., Ltd. SFDA H32025935 12 North China Pharmaceutical Hebei Huanuo Co., Ltd. SFDA H13024102 13 North China Pharmaceutical Hebei Huanuo Co., Ltd. SFDA H13024073 14 Hebei Hengli Group Pharmaceutical Co., Ltd. SFDA H13024253 15 Hebei Tianzhi Pharmaceutical Co., Ltd. SFDA H13024245 16 Hebei Dongfeng Pharmaceutical Co., Ltd. SFDA H13024170 17 Hebei Jinzhuan Pharmaceutical Co., Ltd. SFDA H13024269 18 Tianjin Baihai Pharmaceutical Co., Ltd. SFDA H12021099 19 Henan Daxin Pharmaceutical Co., Ltd. SFDA H41024876 20 Henan Daxin Pharmaceutical Co., Ltd. SFDA H41025013 21 Shanxi Xinxing Pharmaceutical Co., Ltd. SFDA H14023068 22 Jiangxi Jiminke Pharmaceutical Co., Ltd. SFDA H36022305 23 Suzhou Hongsun Pharmaceutical Co., Ltd. SFDA H32025897 24 Jiangsu Puhua Kesheng Pharmaceutical Co., Ltd. SFDA H32026256 25 Guangxi Tiantianle Pharmaceutical Co., Ltd. SFDA H45021319 26 Tianjin Central Pharmaceutical Co., Ltd. SFDA H12021120 27 Tianjin Central Pharmaceutical Co., Ltd. SFDA H12021117 28 Shanghai Modern Harsen (Shangqiu) Pharmaceutical Co., Ltd. SFDA H41024989 29 Tianjin Pacific Pharmaceutical Co., Ltd. SFDA H12021100 30 Hebei Guojin Pharmaceutical Co., Ltd. SFDA H13023940 31 Hebei Kaiwei Pharmaceutical Co., Ltd. SFDA H13023920 32 Hebei Sanshi Pharmaceutical Co., Ltd. SFDA H13023928 33 Yuanda Pharmaceutical (China) Co., Ltd. SFDA H42022649 34 Shanxi Tongda Pharmaceutical Co., Ltd. SFDA H14023309 35 Shanxi Guorun Pharmaceutical Co., Ltd. SFDA H14023402 36 Shanxi Fenhe Pharmaceutical Co., Ltd. SFDA H14023200 37 Shanxi Wanhui Pharmaceutical Co., Ltd. SFDA H14023333 38 Jilin Wantong Pharmaceutical Co., Ltd. SFDA H22025288 39 Changchun Overseas Pharmaceutical Group Co., Ltd. SFDA H22026726 40 Shijiazhuang Xiehe Pharmaceutical Co., Ltd. SFDA H13024084 41 Shandong Xinyi Pharmaceutical Co., Ltd. SFDA H37023541 42 Kuihua Pharmaceutical Group (Hengshui) Defier Co., Ltd. SFDA H13023979 43 Shijiazhuang Kanghewai Pharmaceutical Co., Ltd. SFDA H13024261 44 Shandong Xinhua Pharmaceutical Co., Ltd. SFDA H37023523 45 Hebei Yuzhilin Pharmaceutical Co., Ltd. SFDA H13024426 46 Xinhai Yansheng Pharmaceutical Co., Ltd. SFDA H41024907 47 Fu'an Pharmaceutical Group Yantai Zhichu Pharmaceutical Co., Ltd. SFDA H37023543 48 Dingfukang Pharmaceutical Co., Ltd. SFDA H41025139 49 Dingfukang Pharmaceutical Co., Ltd. SFDA H41025174 50 Changchun Changqing Pharmaceutical Group Co., Ltd. SFDA H22025234 51 Henan Baiquan Pharmaceutical Co., Ltd. SFDA H41024840 52 Changzhou Kangpu Pharmaceutical Co., Ltd. SFDA H32025910 53 Henan Baiquan Pharmaceutical Co., Ltd. SFDA H41025575 54 Lepu Hengjiuyuan Pharmaceutical Co., Ltd. SFDA H41024862 55 Hebei Ruicen Pharmaceutical Co., Ltd. SFDA H13023953 56 Hainan Xiansheng Pharmaceutical Co., Ltd. SFDA H46020588 57 Hainan Xiansheng Pharmaceutical Co., Ltd. SFDA H46020604 58 Yaodu Pharmaceutical Group Co., Ltd. SFDA H13023951 59 Shandong Xinyi Pharmaceutical Co., Ltd. SFDA H37023939 60 Shijiazhuang Pharmaceutical Group Ouyi Pharmaceutical Co., Ltd. SFDA H13023952 61 Tianfang Pharmaceutical Co., Ltd. SFDA H41024887 62 Lepu Hengjiuyuan Pharmaceutical Co., Ltd. SFDA H41025576 63 Zhejiang Huisong Pharmaceutical Co., Ltd. SFDA H33022412 64 Zhejiang Huisong Pharmaceutical Co., Ltd. SFDA H33022411 65 Shanghai Kaibao Xinyi (Xinxiang) Pharmaceutical Co., Ltd. SFDA H41024834 66 Henan Xueyinghua Pharmaceutical Co., Ltd. SFDA H41024896 67 Henan Xueyinghua Pharmaceutical Co., Ltd. SFDA H41025009 68 Shijiazhuang Pharmaceutical Group Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd. SFDA H13023994 69 Handan Furong Pharmaceutical Co., Ltd. SFDA H13024077 70 Hebei Tiancheng Pharmaceutical Co., Ltd. SFDA H13024056 71 Hebei Kangtai Pharmaceutical Co., Ltd. SFDA H13024041 72 Guangdong Bidi Pharmaceutical Co., Ltd. SFDA H44025328 73 Guangdong Bidi Pharmaceutical Co., Ltd. SFDA H44024963 74 Zhengzhou Furuitang Pharmaceutical Co., Ltd. SFDA H41025579 75 Chongqing Kerui Pharmaceutical (Group) Co., Ltd. SFDA H50021730 76 Baiyun Mountain Dongtai Shangqiu Pharmaceutical Co., Ltd. SFDA H41024872 77 Xinxiang Changle Pharmaceutical Co., Ltd. SFDA H41024895 78 Xinxiang Changle Pharmaceutical Co., Ltd. SFDA H41025012 79 Baiyun Mountain Dongtai Shangqiu Pharmaceutical Co., Ltd. SFDA H41025008 80 Tianfang Pharmaceutical Co., Ltd. SFDA H41025010

Drug ApprovalNDA

20 Dec 2024

·www.prnewswire.com

Chungnam National University Researchers Develop A Rapid Water Quality Monitoring Chip for Antibiotic Detection

DAEJEON, South Korea, Dec. 20, 2024 /PRNewswire/ -- Antimicrobial resistance (AMR) is a growing global health crisis because of microbes, such as bacteria, becoming resistant to antibiotics. A leading factor in this rise is the improper use and disposal of antibiotics in the environment. Effluents from wastewater treatment plants often contain various antibiotics including trimethoprim (TMP), which can harm ecosystems by disrupting microbial communities essential for nutrient cycling. In addition to contributing to AMR, TMP poses various health risks to humans through indirect exposure. Continue Reading Scientists developed a simple TMP detection device for on-site monitoring of contaminated wastewater using selenite-enriched lanthanum hydroxide electrode and polyimide-filter microfluidic channel. Traditional methods for TMP detection such as capillary electrophoresis and liquid chromatography with mass spectrometry, are often labor-intensive and time-consuming. Electrochemical (EC) methods can provide respite from these issues by offering exceptional sensitivity, real-time analytical capabilities and the potential for miniaturization. Professor Tae Yoon Lee and Dr. Natarajan Karikalan of Chungnam National University, Korea, have made a pioneering advancement in EC detection methods, that shows promise to revolutionize on-site testing for TMP in contaminated wastewater. They developed a disposable microfluidic lab-on-a-chip (LOC) EC sensor, μTMP-chip, designed for real-time TMP detection. "Efficient TMP monitoring in effluents is critical for effective control protocols. Hence, we aimed to enable in situ testing of water samples," explains Prof. Lee. Their paper was made available online on September 21, 2024 and was published in Volume 499 of Chemical Engineering Journal on November 1, 2024. The researchers designed the disposable chip by combining a special electrode made with lanthanum hydroxide and selenite, with a polyimide (PI) filter in a microfluidic channel. The analyses showed that the addition of selenite improved the electrode's ability to detect chemicals by allowing better charge flow. Additionally, the PI filter improved the μTMP-chip's real-time performance, while the efficiency dropped by 15 to 45% when the filter was removed. Additionally, the filter helped trap and isolate unwanted materials and prevented the risk of microbial growth, which could interfere with the sensor's function. The μTMP-chip sensor demonstrated impressive results in real-world testing, showing recovery rates of 94.3 % to 97.6 % in soil and water samples. These results, obtained through wireless testing, highlight the chip's potential for practical use in monitoring environmental samples. "Our current design may face challenges in detecting TMP in highly polluted environments with significant matrix interferences. However, we hope our research will inspire further exploration into developing affordable and efficient TMP detection chips," said Prof. Lee. The researchers believe that their innovative lab-on-a-chip design has the potential to improve the feasibility of on-site, real-time tracking of environmental contaminants leading to improved conservation of ecosystems and human health. Reference Title of original paper: Microfluidic sensor integrated with selenite-enriched lanthanum hydroxide and in situ filtration for the on-site detection of the antibiotic trimethoprim in environmental samples Journal: Chemical Engineering Journal DOI: 10.1016/j.cej.2024.155982 About the institute Website: Media Contact: Gaeun Kim +82 42-821-6239 [email protected] SOURCE Chungnam National University WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

Clinical Result

04 Nov 2024

·www.drugs.com

Nitrofurantoin, Cranberry Products May Cut UTI Episodes in Children

MONDAY, Nov. 4, 2024 -- For children with a history of recurrent urinary tract infection (RUTI), nitrofurantoin and cranberry products may reduce the incidence of symptomatic UTI episodes, according to a review published online Nov. 4 in Pediatrics . Nikolaos Gkiourtzis, M.D., from the Aristotle University of Thessaloniki in Greece, and colleagues conducted a systematic literature review of randomized controlled trials comparing prophylaxis options for the prevention of UTI and kidney scarring in children with a history of RUTI. A total of 3,335 participants from 23 studies were included in the meta-analysis. The researchers found that cranberry products (compared with the control group) and nitrofurantoin (compared with the control, trimethoprim-sulfamethoxazole, or trimethoprim groups) led to lower odds of symptomatic UTI episodes during prophylaxis. Compared with all available documented interventions, nitrofurantoin appeared to be the best option for reduction in the incidence of UTI. None of the prophylaxis options showed a reduction in kidney scarring. "Future studies with optimal methodology, studying nonantibiotic prophylaxis options, focusing on children with RUTI, and the risk for kidney scarring are needed to draw further conclusions," the authors write. Abstract/Full Text Editorial (subscription or payment may be required) Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

Clinical Result

100 Deals associated with Trimethoprim

External Link

KEGG	Wiki	ATC	Drug Bank
D00145	Trimethoprim	J01EA01	DB00440

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Urinary Tract Infections	Australia	Arrotex Pharmaceuticals Pty Ltd.Startup	02 Aug 1991
Bacterial Infections	United States	Monarch Pharmaceuticals LLC	30 May 1980

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Acquired Immunodeficiency Syndrome	Clinical	United States	Lederle Laboratories	31 Aug 2001
Pneumonia, Pneumocystis	Clinical	United States	Lederle Laboratories	31 Aug 2001

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT03746106 (CTgov)	Phase 4	Thiamine Deficiency	7	Thiamine (Thiamine Alone)	jsxdpgbpkk(xbibljuwig) = rbpsmguxze fxmvxphnsq (lpzfthabnf, 9.5) View more	-	03 Jan 2025
NCT03746106 (CTgov)	Phase 4	Thiamine Deficiency	7	Thiamine+Trimethoprim (Thiamine Co-administered With Trimethoprim)	jsxdpgbpkk(xbibljuwig) = jnehvvrnio fxmvxphnsq (lpzfthabnf, 22) View more	-	03 Jan 2025
SNMMI2023	Not Applicable	-	-	m[131I]I-TMP	ajbswrmufa(wzhncejsoy) = utrrqzutwp orvnhocwjv (jxnzxurnbt )	-	28 Aug 2023
SUN-185 (ENDO2020)	Not Applicable	Hyponatremia \| Hypoaldosteronism	-	Trimethoprim-sulfamethoxazole (TMP-SMX)	tkqxwmtmqa(vcdjcdelwt) = jagksayygf llprparwoa (vpucrdcszd ) View more	-	08 May 2020
SUN-185 (ENDO2020)	Not Applicable	Hyponatremia \| Hypoaldosteronism	-	Intravenous hypertonic saline and oral salt tablets	yhjhpdkxnu(woipsfxzsd) = tihidyrfja txijabszdc (lkdxhvewdh ) View more	-	08 May 2020
NCT03077711 (CTgov)	Phase 4	Urinary Tract Infections	92	Methenamine hippurate (Patients With Recurrent UTIs Arm 1)	jdtpswcgkd(eiitlaqioe) = txepqfpajq ypsyqvuaig (qaaehxxvco, 84.4) View more	-	14 Jan 2020
NCT03077711 (CTgov)	Phase 4	Urinary Tract Infections	92	Trimethoprim (Patients With Recurrent UTIs Arm 2)	jdtpswcgkd(eiitlaqioe) = ojladwneeh ypsyqvuaig (qaaehxxvco, 94) View more	-	14 Jan 2020
SP285 (ERA2019)	Not Applicable	Chronic Kidney Diseases creatinine	20	Trimethoprim	plihmrdnnd(qssbzdxtrp) = fofjzycqov aojersmxak (rksxsptwee )	Positive	13 Jun 2019
ASN2014	Not Applicable	Hyponatremia	48	High dose TMP-SMX	acvwuijilj(hcpgdvhush) = aochmqmefn kzaoydkawt (pnkjjmxhvd )	Positive	11 Nov 2014
DRKS00000481 (Pubmed \| Br J Clin Pharmacol)	Not Applicable	-	-	Metformin 500 mg	hytlwtyupn(dvzcealbzv) = qbosukaucx kyksfdmaxw (pmwhzsuind ) View more	-	01 Nov 2013
DRKS00000481 (Pubmed \| Br J Clin Pharmacol)	Not Applicable	-	-	Trimethoprim 200 mg	fsrccrtbrq(odixvywvgh) = hpzghzqoyi lcsbfofdvw (ufxkowewjd ) View more	-	01 Nov 2013
AAAAI2013	Not Applicable	Systemic Lupus Erythematosus anti-Ro/SS-A antibody	31	TMP/SMX	iratbcfhbp(jnwtvurujg) = gftquiofau pvhjezhili (rjbpebrbwy )	Positive	01 Feb 2013
NCT00014911 (CTgov)	Phase 2	Diabetes Mellitus, Type 1	36	Islet Transplantation+Ganciclovir+Sulfamethoxazole+Tacrolimus+Sirolimus+Daclizumab+Pentamidine+Trimethoprim	hlmmpheksn = qiktgnpngu dngymtowql (bxjbnwrjuh, tvkbpwncnz - nggqcxlksm) View more	-	17 Oct 2012
AAAAI2007	Not Applicable	Acquired Immunodeficiency Syndrome	6	Sulfa (HIV/AIDS patients)	ncwilwbjvy(gegylmrnrf) = 5/6 developed cutaneous burning sensation followed by generalized maculopapular rash with a median onset after the last dose of 12 hours. Only antihistamines were used. The symptoms resolved within 6 days (median of 2 days, range 1-6 days) rgghqduedx (rrcwyweort )	-	01 Jan 2007

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